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Simulations unravel outer membrane transport mechanism

... force needed to pull the luminal domain downward, away from the barrel" Second, how does the luminal doma...ct while TonB pulled the end of the luminal domain away from the barrel. The simulation also showed the luminal domain gradually unfolding, changing its con...

New bacterium discovered -- related to cause of trench fever

...pital Medical Center. “The bacteria were eating away a bone in the arm of an AIDS patient – for months,” Koehler recalls. “They can cause extremely painful lesions and tumors of blood vessels on the skin of immunocompromised patients. But when I saw this patient, this type of infection had never been ...

Brightening prospects of using fluorescent nanotubes in medical applications

...suing research that uses gold nanoclusters to burn away cancer cells. He has developed a selective method for attaching the gold clusters to the surface of tumors and then exposing them to wavelengths of light that cause them to grow hot enough to destroy nearby cells. The approach has one drawback: He do...

Migration alert -- How tumor cells home in on the lymphatic system

... fluid, there will always be slow fluid flow going away from the tumor into the lymphatic vessel. This slow flow biases the concentration distribution of this molecule towards the lymphatic, and the tumor cell follows it, like the proverbial carrot on a stick. Near the vessel, concentrations of the signal...

Microbes at work cleaning up the environment

...ia excreting proteins for nanoparticle aggregation away from the cells,” said Peter Weber, one of the LLNL authors of the paper appearing in the June 15 edition of the journal Science. Weber and LLNL colleague Ian Hutcheon used LLNL’s NanoSIMS (high- resolution secondary ion mass spectrometer) to study...

In nature, proteins sweep up nanoparticles

...articles into piles that are too large to be swept away by underground currents. Precisely how and why the...als that takes place as far as hundreds of microns away from the cell.” In other words, in addition to pumping nano-sized sulfide waste particles into th...

Research finds that circadian rhythms dominate all life functions

...harder to detect. "It's like a conductor walking away from an orchestra during a performance; each musician continues to play, gradually going out of key with the others," said Ptitsyn. That is one likely reason why researchers previously missed the impact of circadian rhythm on all genes. Depending u...

Prey not hard-wired to fear predators

...r predators they regularly encounter. If you take away wolves, you take away fear. That is a critical piece of knowledge as biologists and public agencies increase efforts to r...

Want to save polar bears? Follow the ice

...the unpredictability of the melting of the sea ice away from the coast regions that bears shift to in the warmest parts of the year. Bears that make it to shore may be there for increasingly longer periods of time without food as the sea ice becomes more distant and inaccessible. The main question fo...

Mule deer moms rescue other fawns

...came close to the speaker tended to withdraw right away and then stayed safely outside that distance. The behaviour of mule deer defies traditional explanations that parental care, kin selection or reciprocity play a part in the defence of fawns other than their own. But while the study's findings seem...

Mice with a migraine show signs of brain damage

...s like potassium and sodium out of balance, taking away the brain’s ability to function efficiently. This ...xygen as fast as they can, leaving tissues further away with a diminished supply. It’s like a pride of lion cubs fighting for their mother’s milk ?a few may...

Technique monitors thousands of molecules simultaneously

... molecules, treating it with the receptor, washing away any excess receptor that has not found a key, and ... chemistry I want it to do ?but as soon as it gets away from the turned-on electrode the reaction that inactivates it needs to take over." With an overall...

Simple home spit test to spot deadly pre-eclampsia

...chards Hospital in Chichester. Trial subjects send away saliva-wiped swabs for analysis. Results are expected early next year. The ultimate aim is to develop a "traffic light" detection kit for use in the home. Pre-eclampsia is thought to be the result of problems relating to the implantation of the pl...

Traumas like Sept. 11 make brains more reactive to fear

...red with those who were living more than 200 miles away at the time; none of the subjects had psychiatric disorders. "We know that looking at fearful faces in normal adults tends to activate the amygdalae relative to looking at neutral faces," said Ganzel. "So we were looking to see if people who have h...

DNA repair proteins monitored at double-strand break

...e its repair—even when particular proteins shifted away from the break to make room for others. A report on this work appears in the May 7 online issue of "Nature Cell Biology." The findings are important because disruption of the precise movement of these repair proteins can cause mutations, cell d...

Study shows continued success for new HPV vaccine against virus responsible for cervical cancer

... most people, HPV causes no complications and goes away on its own. However, in some cases, if left untreated, certain high-risk types of HPV can lead to cervical cancer. "The goal of the study was to see if we could prevent precancerous cases and we were 98 percent effective. Everyone who gets cance...

DOE JGI sets 'gold standard' for metagenomic data analysis

...es, particularly since this gold rush is not going away any time soon." ...

Spreading viruses as we breathe

... current belief is that if you are an arm's length away from someone you are protected from any viruses they might be carrying," she said. "When we talk about infection spread we are talking about droplets emitted from humans being dispersed in the air." As part of the study QUT designed and built a...

Biodegradable microspheres deliver time release vaccines, stimulate different immune response

...Everlasting Gobstopper or a bar of soap. It wears away slowly over time, delivering its payload," says Wilson-Welder. The researchers vaccinated mice with microspheres loaded with ovalbumin, a protein from chicken eggs, and measured immune reponse. While mice exhibited the expected antibody response,...

MIT's ocean model captures diversity of underwater forests

...f, have a bit of a reductionist view. We often shy away from the complexity of the real world in our models and prefer to reduce things to the simplest case with fewest factors," said Follows, who went through a sort of conceptual evolution after collaborating with Chisholm for several years. "I finally s...

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