Tag: "autophagy" at biology news

Targeted virus compels cancer cells to eat themselves

...ization among the cancer cells -- a process called autophagy -- to reduce tumor size and extend survival, says ... adenovirus) infected the glioma cells and induced autophagy by inactivating a molecular pathway -- the mammalian target of rapamycin (mTOR) pathway -- that is...

Tumor cells evade death through autophagy

...the University of Pennsylvania have now shown that autophagy represents a survival mechanism for tumor cells tr...tosis was induced by activation of p53 expression, autophagy was observed only in tumor cells not undergoing apoptosis. If mice were unable to initiate autophagy...

Protein found to shield pancreatic cancer cells from self-destruction

...xpression (up to 94 percent) and telltale signs of autophagy in the cancer cells, which became riddled with cavities called vacuoles. When autophagy occurs, a double membrane forms around a cell organ, or organelle. This autophagosome then merges wi...

Scientists find new genes for Crohn's disease

...minate some pathogenic bacteria—a pathway known as autophagy (pronounced AU-TOF-A-GEE ). Finding ATG16L1's ...6L1 gene leads to alterations in how the body uses autophagy and therefore may result in increased persistence of [toxic] cellular and bacterial components. This...

Penn researchers link cell's protein recycling systems

...t worse,” says Taylor. “Then when we activated the autophagy system by feeding the flies a drug called rapamyci...ed that if the HDAC6 gene is knocked out, inducing autophagy no longer rescues the fly eyes from neurodegeneration. Therefore, autophagy requires HDAC6 to work. ...

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