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Tag: "autoimmune" at biology news

Breakthrough developments in rheumatoid arthritis reported

...pathways underlying rheumatoid arthritis and other autoimmune diseases. It may ultimately provide tests to pred...S population will develop rheumatoid arthritis, an autoimmune disease that leads to painful joint swelling. Scientists are cracking the genetic code that makes th...

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

...he mechanism involved in the vascular lesion is of autoimmune origin: antibodies directed against particular proteins of the virus are able to bind molecules expressed on the surface of the cells that line the arterial walls (endothelial cells) and to cause their death (apoptosis) through a mechanism called "mo...

Molecule that destroys bone also protects it, new research shows

...mary cause of bone destruction and inflammation in autoimmune diseases such as rheumatoid arthritis actually pro...mary cause of bone destruction and inflammation in autoimmune diseases. Therapies that target IL-17 or its cellular receptor currently are being developed. How...

Herpes infection may be symbiotic, help beat back some bacteria

...ee animal models scientists use to study vaccines, autoimmune diseases, and other immune system issues have the potential to produce misleading results. "Chronic virus infections may in part define what a normal human immune response is," says Virgin, who is the Edward Mallinckrodt Professor of Pathology and...

UCLA study uncovers clues for why Graves' disease attacks the eyes

...y, their study may deepen understanding of how the autoimmune disorder damages the body and offer a new target f...he survival of older T-cells, causing a cascade of autoimmune problems that spur the body to attack its own tissue. "We think that the extra receptors allow th...

Scripps research study shows humans and plants share common regulatory pathway

...d to diseases that involve chronic inflammation or autoimmune consequences. Up to now, there has been a limited understanding of the regulatory pathways of Nod1. By identifying SGT1 as a positive regulatory protein, our study offers new insights into the entire family." SGT1 is a protein found in yeasts, pla...

New details on how the immune system recognizes influenza

...clude adding data on epitopes that are involved in autoimmune diseases and epitopes that trigger allergic and asthmatic reactions. Dr. Sette and his colleagues have also built numerous tools for analyzing and visualizing the data and for predicting immunity against different pathogens--all of which is publicly ...

Scientists learn the origin of rogue B cells

... of the body it is designed to protect, leading to autoimmune disease. Now, researchers at the National Institut...w this knowledge might eventually help people with autoimmune disease. That question, says Casellas, is one that will take time to answer. "This is only one step,...

Microbes start immune response by sneaking inside cells

...ry response in rheumatoid arthritis and some other autoimmune diseases. “In our study, the presence of bacterial microbes inside the cell is what triggers the immune response. That creates a new perspective for developing new drugs,?says senior author Gabriel Nunez, M.D., the Paul H. de Kruif professor of pa...

Antibody therapy prevents type 1 diabetes in mice

...re than 700,000 Americans have type 1 diabetes, an autoimmune disorder in which the body errantly attacks the insulin-producing cells of the pancreas, causing chronically elevated levels of sugar in the blood, leading to blindness, kidney failure, heart disease and nerve damage. Previously known as juvenile dia...

Why doesn't the immune system attack the small intestine?

...une system, may lead to new forms of treatment for autoimmune diseases such as Type 1 diabetes and multiple scle..., they may offer a way of suppressing a variety of autoimmune diseases," which result from immune system assault on healthy tissue. The immune system distinguis...

Parasite infection may benefit MS patients

A steady rise in autoimmune diseases such as multiple sclerosis (MS) has been ... infectious diseases may play a role in increasing autoimmune disease incidence. The first study examining the relationship between parasite infections and MS in ...

Cracking open the black box of autoimmune disease

...ntified a key set of genes that lie at the core of autoimmune disease, findings that may help scientists develop... "This may shorten the path to new therapies for autoimmune disease," says Whitehead Member and MIT professor of biology Richard Young, senior author on the pap...

A revolution in the monitoring of unborn babies

...ose mothers have medical conditions like diabetes, autoimmune conditions such as systemic lupus erythematosus and Sjogren’s syndrome and obstetric cholestasis. It will also be useful in monitoring fetuses identified as growing poorly or where it is suspected that the placenta is unhealthy and hence the fetus ma...

Minuscule molecules pack a powerful punch

...he mice develop symptoms similar to those of human autoimmune disease. They are also less able to resist infecti...th scarring that is similar to some human systemic autoimmune disorders. To uncover how miR-155 might cause such widespread disruption of the immune system, th...

New insights into autoimmunity and depression

...sus (SLE), often simply called lupus, is a complex autoimmune disease marked by joint pain, skin rashes, extreme fatigue, and depression, among other symptoms. Some studies have described a possible link between SLE’s most severe psychiatric manifestation, psychosis, and a protein autoantibody associated with t...

Interaction between lymph and liver cells may affect immune response

...ul in developing therapies for viral hepatitis and autoimmune diseases. The results of this study appear in the November 2006 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., Hepatology is available online v...

Vaccination with embryonic stem cells prevents lung cancer in mice

...ed tumours. None of the vaccinated mice developed autoimmune disease or a showed a significant decline in adult pluripotent bone marrow stem cells ?both potential adverse responses to the vaccinations. Prof Eaton said: "We think the results from the carcinogen-initiated cancers are probably the most importa...

Scientists explore how complex organs develop from a simple bud

...y glands have been injured by radiation therapy or autoimmune rejection. An investigation into the morphogenesis of the prostate gland and seminal vesicles is included, as well as an in-depth look at the genetic and cellular interactions critical to placental development. Research on this process in mouse kidne...

T for two: Scientists show how immune system chooses best way to fight infection

...related to the immune system, including cancer and autoimmune diseases such as type I diabetes and arthritis. Th...nt or regulatory T cells in someone suffering from autoimmune disease, both of which are caused by the immune system malfunctioning." Professor Hayday and his ...

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