Scientists force viruses to evolve as better delivery vehicles for gene therapy
...s, resident of the body that has received a lot of attention in recent years as a possible carrier for genes in gene therapy. Because as many as 90 percent of people already have the virus, however, their immune systems are primed with antibodies to quickly tackle and neutralize it, thwarting any attempt at ge...Molecular mechanism may explain how fevers spark seizures
...rld," Macdonald said. "Our findings are attracting attention because they show a novel mechanism for febrile seizures, and now that we know a vulnerable step, we can in principle design therapeutic strategies to overcome it." ...Viral 'fitness' explains different resistance patterns to aids drugs
...eve that when new drug classes are developed, more attention should be given in defining how virologic fitness determines how different patterns of taking medications may lead to resistance" said Steven Deeks, MD, associate professor of medicine at UCSF's Positive Health Program at SFGHMC and senior author on ......ate achieved is the result of innovation and great attention to experimental detail." Due to the small size of its genome, short reproductive cycle and small plant size, F. vesca is an ideal model system for genomics in commercial strawberry. The rapid growth of new shoots, the high number of seeds generated...Losing sleep undoes the rejuvenating effects new learning has on the brain
...ction. Sleep-restricted individuals have a shorter attention span, impaired memory, and a longer reaction time....dly than healthy counterparts, a phenomenon called attention switching. This suggests that learning to ignore stimuli and rapid attention switching are competin...Flu not the only germ threat this time of year
...ttack the GI system, and so on. While the world's attention has migrated to bird flu, not a single person in t...gets all the press, RSV is a stealth bug worthy of attention too. Ann Falsey, M.D., and Edward Walsh, M.D., faculty members in the University's Infectious Disea...Rare Chinese frogs communicate by means of ultrasonic sound
...ion for being able to do this." Adler had drawn attention to the species because the frogs do not have external eardrums, raising the possibility of unusual hearing abilities. "Now we are getting a better understanding of why their ear drums are recessed," Feng said. "Thin eardrums are needed for detection ...Chemical guidance of T cells leads to immunologic memory and long-term immunity
...havior of the immune system, but also suggest that attention needs to be paid to chemokines and chemokine receptor function when designing new vaccine strategies and evaluating whether drugs targeting chemokines might have unanticipated effects on immune function. ...Less is more, gene study shows
...hind the loss. So the researchers focused their attention on another human-specific pseudogene, CASPASE12. Work by other researchers had shown that the gene has completely lost its function in non-Africans, but a small percentage of Africans and African Americans have a functional copy of the gene. Interest...How 'hot' emotional brain interferes with 'cool' processing
...le someone driving on a highway, attempting to pay attention to the driving task might encounter an emotional distracter such as an accident. As everybody knows, at that moment drivers lose focus on the task." "Also, the three types of distracters gave us good controls, which allowed us to clearly establish t...Stanford study of owls finds link in brain between sight and sound
.... What was previously known about the mechanism of attention was based on research done by other scientists - i..., PhD - who have looked at how monkeys focus their attention on things they see. These researchers have found that when a monkey decides to turn its eyes, the re...Manipulating single cell receptor alters animal behavior
... and central control of behavior. "A good deal of attention had been paid to the intracellular signaling pathways under the control of the receptors for angiotensin," he says, "but our research makes strides toward understanding how these processes mechanistically affect behavior." Daniels's research in beh...'Executive' monkeys influenced by other executives, not subordinates
... humans supported the idea that it was a reflexive attention mechanism," said Platt. "People in those studies would tend to shift their attention where they saw another person looking, even if it wasn't predictive of some event happening around t...For one Stanford doctor, the beat goes on during open-heart surgery
...cedure, beating-heart surgery has garnered renewed attention recently as the trend toward less-invasive methods of heart surgery grows stronger. "We need to be researching this," said Robert Robbins, MD, chair of the cardiothoracic surgery department at the School of Medicine, who hired Ihnken this summer to ...Marine mammals are on the frontline of failing ocean health
...the University of California at Davis. "By paying attention to them, it will tell us about our own health and ...ore easily detect and trace the disease ?and calls attention to the flow of pathogens from land to sea that might otherwise go unnoticed. Conrad recommends th...Researchers reverse juvenile diabetes in animal model
...sponse by bringing these foreign substances to the attention of T cells. Once harvested, researchers then combine the dendritic cells with specific blockers of molecules, known as CD40, CD80 and CD86, all of which can be synthesized in a laboratory. This treatment strategy was found to inhibit the interaction...Infection 'alarm' yields clues to immune system behavior
...en the immune system overreacts or pays too little attention to the infection alarm. Collaborating with colleagues at the University of California, San Diego, the Johns Hopkins researchers have used their discoveries to develop a new computer model that could help produce medications for immune system-related...Infants can organise visual information at just four months
Research investigating attention in infancy has revealed that, at just four months ... research investigating different styles of visual attention in babies from the age of two to eight months. Paying attention to visual stimuli is important in th...Birth defects: 8 million annually worldwide
... report say that it is a common misconception that attention to birth defects will draw funding from other priority public health efforts -- when, in fact, increased efforts to reduce birth defects in children contributes to the health of the entire population. Their recommendations in this report are aimed b...Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
.... Vitetta's work with ricin received international attention when she and a team of UT Southwestern researchers in the Cancer Immunobiology Center developed the experimental vaccine for the deadly toxin as an outgrowth of their cancer-therapy work. Dr. Vitetta, Dr. Joan Smallshaw, assistant professor in the ce...