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Tag: "attacking" at biology news

A single sugar found responsible for an antibody's ability to treat inflammation

...y and deactivate foreign invaders. When they begin attacking the body's own cells, the same protective immunoglobulins (known as IgG antibodies) can cause autoimmune disorders like lupus, arthritis and asthma. And yet, when IVIG is infused into people with those exact autoimmune conditions, it calms inflammati...

Tumor wizardry wards off attacks from the immune system

...a therapy for pancreatic cancer patients. "We're attacking the problem from different angles hoping to translate these findings to our patients," Linehan says. "Right now, no effective treatment exists for pancreatic cancer." ...

Finding paves way for better treatment of autoimmune disease

...t work like beat cops keeping misguided cells from attacking the body. The ability to easily make large numbe...e a small subset that prevents the cells from also attacking body tissue. Research published in the August issue of Nature Methods shows that, given the opt...

Can you hear me now? Scientists find previously unknown receptors on adult stem cells

... enlisting them to help fight whatever pathogen is attacking the body. The findings, which appear in the June issue of the journal Immunity, could have important implications for treating leukemias and autoimmune diseases such as lupus and rheumatoid arthritis. "We have long known that so-called hematopoieti...

Buckyballs boost antibody's chemotherapy payload

... on the possibility of their escaping treatment by attacking them with more than one kind of drug at a time." Researchers have long dreamed of using antibodies like ZME-018 to better target chemotherapy drugs like Taxol, and M. D. Anderson's Michael G. Rosenblum, Ph.D., professor in the Department of Experime...

African parasite makes component of fat differently from all other organisms

...gases to make them," says Englund, suggesting that attacking biochemical pathways that make fatty acids could be a way to treat sleeping sickness. According to the researchers, the research community is extremely interested in developing drugs that target bacterial enzymes involved in fatty acid synthesis. An ...

Bt cotton in China fails to reap profit after seven years

...lif., today (July 25), is that other pests are now attacking the GM cotton. The GM crop is known as Bt cotton, shorthand for the Bacillus thuringiensis gene inserted into the seeds to produce toxins. But these toxins are lethal only to leaf-eating bollworms. After seven years, populations of other insects - s...

New pathways for autoimmune treatment identified

...nfections while suppressing errant T cells bent on attacking the body, Medical College of Georgia researchers say. This finding opens new pathways for treating or preventing APS1, or autoimmune polyglandular syndrome type 1, and potentially other autoimmune diseases as well, researchers report in the June iss...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

...es IL-23, which appears to be very well suited for attacking gliomas. Earlier studies used IL-4, IL-12, and tumor necrosis factor related apoptosis inducing ligand (TRAIL). "Each cytokine has unique functions. What we want to do is marry the function with the therapeutic response we want to achieve. Interleuk...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

... the way it is absorbed into cancer cells and then attacking the DNA of those cancer cells. The findings may help researchers design a new generation of anti-cancer drugs that selectively target cancer cells, reduce resistance and side effects and expand the range of tumors that can be treated by platinum. ...

U-M scientists identify major psoriasis susceptibility gene

...rep infection is cleared, the immune system starts attacking the patient's own skin cells. About half the time, strep-induced psoriasis goes away and never comes back. But for the other 50 percent of young people who get it, psoriasis progresses to become a chronic life-long disease." The PSORS1 gene is actu...

New cellular flaw found in some virulent breast cancers

...aggressive form of breast cancer, and suggest that attacking this target with selective drugs might improve treatment. In the January issue of Cancer Cell, a team led by Qunyan Yu, MD, and Peter Sicinski, MD, PhD, of Dana-Farber report that the interaction of a certain mutated oncogene and the newly describe...

Sea slug mixes chemical defense before firing at predators

... mechanism insures the secretion's potency against attacking predators to enable sea slugs to escape." Aplysia employs a variety of mechanisms to defend against predators. Its secretion stimulates feeding behaviors in spiny lobsters, but deters these behaviors in other animals. In previous studies, Derby and ...

Scavenger cells could be key to treating HIV-related dementia

...n the temporal lobe than other parts of the brain, attacking macrophages migrate there in a constant stream, causing harmful inflammation. Nearly 15 percent of HIV patients develop dementia as their disease progresses. But understanding the routes macrophage cells take in the brain could help researchers find...

How HIV disables the cells' call for help

...lay host to HIV viruses are overactive, mistakenly attacking the body's cells instead of foreign invaders. If the viruses use FPs to override the cells' call for help, could their actions, which block one type of immune response without killing the cell, be applied to these autoimmune diseases? To check their ...

Discovery of T-cell 'traffic control' boosts new drug promise

...on -- a crucial response that sometimes goes awry, attacking the body's own tissues and causing autoimmune diseases. The traffic control system -- composed of a fat-like compound called S1P and its receptor on T cells -- usually prevents T cells from launching harmful reactions. But when the S1P traffic cop r...

New Lab Research May Help Those Deafened By Immune System Attack

...ease, destroying invading microbes with a swarm of attacking cells. But it can also go haywire for no apparent reason, ganging up on normal tissues in our body and wreaking havoc. In thousands of people each year, the immune system attacks the inner ear, home to the tiny, delicate structures that allow us to ...

Why are coyotes getting more aggressive?

...ted States, including southeastern New York state, attacking neighborhood pets on the fringe of urban and subur...ually the last stage before coyotes actually start attacking humans -- such as small children that are perceived by the coyotes as a potential food source," says...

Purdue scientists may have found key to halting spinal cord damage

...aid. "The trouble is that when free radicals start attacking tissue, it happens in a tiny fraction of a second, after which they are gone. But the acrolein that these attacks release survives in our bodies much longer, for several days at least, and its toxicity is well documented." For example, acrolein has ...

Bioinformatics reveals new gene regulation system

... Gelfand pointed out that many antibiotics work by attacking the process of bacterial DNA replication. So, he said, this work has identified potential targets for designing new antibiotic drugs. But more importantly, the work shows how molecular discoveries of whole regulatory systems can be made through caref...

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