Finding paves way for better treatment of autoimmune disease
...ls are components of the immune system designed to attack invaders such as bacteria and viruses; regulatory T cells are a small subset that prevents the cells from also attacking body tissue. Research published in the August issue of Nature Methods shows that, given the option, phospholipase D, which t...Ultra low-dose estrogen shown safe for post-menopausal women
... older, as well as with an increased risk of heart attack and stroke. "Those results raised a lot of doubts about whether women should be taking estrogen at all," Yaffe notes. The current study, published in the July 2006 issue of Archives of Neurology, looked specifically at the potential effects of e...Tumor wizardry wards off attacks from the immune system
...onse to cancer cells so that the immune system can attack tumors. But a tumor shielded with T-reg cells could potentially circumvent the immune system's attack and remain safe. In mice implanted with pancreatic cancer, the researchers demonstrated that tumor ...Federal testing for mad cow disease a failure, law review editor says
...ation of abnormal proteins, or prions. The prions attack a cow's brain tissue, causing holes to form. As the brain loses function, the cow becomes disoriented and clumsy. Eventually the animal loses all muscle control and is unable to walk or eat. No treatment is available. Enforcement of cattle-feed res...A sweet solution for Alzheimer's disease?
... patients will likely still need drugs designed to attack other aspects of Alzheimer's pathology, such as tau neurofibrillary tangles, St George-Hyslop said. "Alzheimer's disease is probably going to be treated by a cocktail of drugs," he predicted. "Some of them might be this compound, or one like it, tha...UCLA study finds same genes act differently in males and females
...that aspirin is more effective at preventing heart attack in men than women. One gender may metabolize the drug faster, leaving too little of the medication in the system to produce an effect." "At the genetic level, the only difference between the genders is the sex chromosomes," said Drake. "Out of the...Scientists tie several cancers to common 'oncogene engine'
...a. The finding suggests that it may be possible to attack these different cancers with the same therapy. Reporting in the June issue of Cancer Cell, the scientists showed that a small transcription factor family, made up of several proteins that control the activity of key growth genes, functions abnormall...C-myc required by the immune system
...evolved such that it stores a 'memory' of previous attack by pathogens. The specialized cells involved in this process are known as 'T memory cells'. The T memory cells are normally maintained at a low level that can be rapidly expanded if the pathogen is detected again. The maintenance of normal, low level...Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes
...uced either of two antibodies, GADA and IA2, which attack islet cells. The study also found that 17 percent of participants who were not c-peptide positive produced GADA or IA2 antibodies to the islet cells, another indication that a small amount of islet cells may still be present and/or functioning. "Th...New study shows antibiotic may protect the heart
...apamycin induces a protective effect against heart attack injury and reduces programmed cell death. Researchers believe through the opening of the mitochondrial KATP channel of heart cells, rapamycin enables cells to maintain ATP levels. Mitochondria are cellular organelles critical for converting oxygen i...Study provides new understanding of spontaneous hybridization
...y were these hybrids resistant to the insects that attack sunflowers, they also produced more seeds than the uncrossed plants. "The results show for the first time that adaptive trait introgression can be a potent evolutionary force, broadening our view of the mechanisms by which populations adapt to thei...Bacteria have their own immune system protecting against outside DNA
...utside sources. Just as immune cells recognize and attack foreign invaders in the human body to protect against harmful infections, single-cell organisms have a protein called H-NS that recognizes foreign DNA and prevents it from becoming active, the researchers discovered. But bacteria can also benefit fr...Healing the heart with bone marrow cells
.... "Each year, 70,000 Canadians suffer from a heart attack and many of them are left with crushing disabiliti... of an infusion of bone marrow cells after a heart attack may prevent progression of heart failure in patients who survived a heart attack. The study may exp...A surprise about our body clock
.... "Each year, 70,000 Canadians suffer from a heart attack and many of them are left with crushing disabiliti... of an infusion of bone marrow cells after a heart attack may prevent progression of heart failure in patients who survived a heart attack. The study may exp...Knowledge of dendritic cells branches out
...inate the existing infection and resist any future attack by memorizing that infection. DC also have an important educative role to play in preventing autoimmune diseases, such as type 1 diabetes and Multiple Sclerosis, where the body's immune system mistakes "self " for "foreign " and launches an attack....Interfering RNA silences genes in 'slippery' immune cells
... infection by helping HIV-infected T cells survive attack by the immune system. Using siRNA and their laboratory techniques, the investigators succeeded in "knocking down," that is, decreasing gene expression by HALP. Because their previous research strongly suggests that HALP promotes latent HIV infectio...Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer
...udy using a vaccine strain of the measles virus to attack recurrent glioblastoma multiforme, a largely untreatable brain tumor. This is the second of several pending molecular medicine studies in patients using measles to kill cancer. "We are looking at better ways to treat some of the most lethal cancers...St. Jude test of bird flu vaccine proves successful
...otection will allow the immune system to track and attack such an emerging new variant without missing a beat," Webby said. "We wouldn't have to wait to start developing a vaccine against it until after the original virus mutated." Webby's team showed that all mice and ferrets that received the DNA vacci...Epstein-Barr virus might kick-start multiple sclerosis
...se of the T cells could lead them to recognize and attack cells they aren't supposed to, like brain cells," said Münz. This process, called molecular mimicry, is seen in other autoimmune disorders, such as lupus. Münz predicted that Edwards, who is returning to Duke University this summer to complete her ......fensive mechanisms by which host plants respond to attack by parasitic plants. ...