Tag: "attaches" at biology news

Drug That 'Tags' Decision-making Areas Of The Brain May Aid

... efforts to study addictedsmokers, a new drug that attaches only to areas of the brain that havebeen implicated in nicotine addiction may help studies of people battling other disorders such as Alzheimer’sdisease and schizophrenia.Developed by UC Irvine Transdisciplinary Tobacco Use Research Centerscientists...

50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel

...n [SUE-mow-e-LAY-shun]. In this process, an enzyme attaches a small peptide called SUMO (for small ubiquitin-like modifier protein) onto another protein. The presence of SUMO alters how the second protein functions. Goldstein's team first demonstrated that the SUMO-conjugating enzyme was plentiful at the pla...

Engineers improve plastic's potential for use in implants by linking it to biological material

...nghvi and Kiley Miller identified the peptide that attaches to polypyrrole from among the billion alternatives initially analyzed. These unique peptides were displayed on the outer surface of a harmless type of virus called a bacteriophage that was purchased commercially. To hunt for the plastic-preferring p...

Scientists discover that three molecules may be developed into new Alzheimer's drugs

...nal." The culprit is an enzyme, called CDK5, that attaches the phosphate to the tau protein, facilitating the... in the same place and this is where the phosphate attaches to the enzyme, in this case CDK5. To get a molecule that specifically prevents the enzyme from bindi...

Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

...nal." The culprit is an enzyme, called CDK5, that attaches the phosphate to the tau protein, facilitating the... in the same place and this is where the phosphate attaches to the enzyme, in this case CDK5. To get a molecule that specifically prevents the enzyme from bindi...

Beetle-inspired switch uses water for bonding

... cling together. When attacked, the palm beetle attaches itself to a leaf until the attacker leaves. It adheres with 120,000 droplets of secreted oil, each making a bridgelike contact between the beetle's feet and the leaf. Each droplet is just a few microns wide. Whereas the beetle controls the oil contac...

Secrets to antibody's success against West Nile Virus surprise scientists

... stopping the process of infection after the virus attaches to host cells." Detailed study of how the antibody physically binds to the virus has provided intriguing clues to how it may block infection. Scientists found evidence suggesting that the antibody prevents the virus from rearranging the protein en...

New Lab Research May Help Those Deafened By Immune System Attack

...veloped a monoclonal antibody, called KHRI-3, that attaches to IESCA in the inner ear, and can be detected in living animal systems and cell cultures. It has allowed them to study IESCA's role in hearing loss in animal models, and show that damage to the inner ear caused by antibodies to IESCA can destroy hea...

Researchers discover how tumor suppressor gene works

...ng a huge complex of proteins, which, when active, attaches to chromosomes and turns on many genes that promot...h. The p16 gene works by producing a protein that attaches to the enzymes, preventing them from performing their function. When the researchers added the p16 p...

Learning how SARS spikes its quarry

...RS infection occurs when the virus's spike protein attaches to a receptor on the surface of target cells. Atta...plore the steps that occur after the spike protein attaches to the receptor. The researchers know that the spike protein undergoes a conformational change that ...

MSKCC researchers uncover structure of key protein complex in cells

...l anticancer therapies. "If sumoylation (when SUMO attaches to a protein) is promoting cell division, then inhibitors of SUMO may be a pretty good agent to block the cell cycle," said Dr. Lima. Postdoctoral researcher David Reverter, PhD, collaborated with Dr. Lima on the work and is the first author on the ...

Vaginal gel may provide a new approach to HIV prevention

... compounds that inhibit the processes by which HIV attaches to and enters target cells could potentially provide a safe, effective and practical way to prevent HIV transmission in women, according to study investigators. The study, published online October 30 in the journal Nature was funded principally by th...

Researcher uncovers details of how cancer spreads

...em. In the study, the researchers found that v-Src attaches to an enzyme, called focal adhesion kinase, inside the cell. This association jump-starts a series of cascading interactions between proteins in the cell that ultimately block some cell-surface proteins from entering through the cell's membrane. One...

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

...a group of molecules called the SCF complex, which attaches ubiquitin to Rb. This inadvertently tags Rb for degradation by the proteosome machinery, the cell's recycling plant. With Rb out of the way, the cell now reproduces uncontrollably. "It's as simple as that, but it's a major mystery solved that many ...

Texas scientists discover how a hepatitis C protein promotes liver cancer

...nabled us to identify a protein known as NS5B that attaches to the retinoblastoma protein, a critical tumor suppressor, and accelerates its breakdown," Lemon said. He continued: "The way NS5B docks with the retinoblastoma protein is biochemically almost identical to the way a protein made by human papilloma v...

Gene needed for butterfly transformation also key for insects like grasshoppers

...it develops. The broad gene encodes a protein that attaches itself to a specific region of a DNA chain and controls which other genes will be copied. The researchers suspect that broad must be present for the physical changes contained in those areas of DNA to be expressed. Suppressing broad prevents the chan...

Light activated anticancer drug targeted to DNA using cisplatin like sub-units

...erapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. However, it also kills healthy tissue. Many scientists are creating alternative drugs or cisplatin analogs in attempts to find treatments without side effects. One approach to analog development is light activated d...

Absence of critical protein linked to infertility

... mice, Bagchi said. During this period, an embryo attaches to the wall of the uterus, advances into it and eventually attaches to the blood supply and forms the placenta. For a successful pregnancy to occur, stromal cells of th...

Molecule by molecule, new assay shows real-time gene activity

...s hybrids migrate to the cell membrane, where each attaches firmly. The clearly visible flash from each Tsr-Venus molecule -- which when viewed across a population of cells looks somewhat akin to a sea of cellular paparazzi -- serves as an indication of that single protein molecule's production. "Dr. Xie's e...

Research details how a virus hijacks cell signals to cause infection

...s and adenovirus receptor (CAR) to which the virus attaches itself. However, the CAR remains below the surface...olved an indirect route of attack. The virus first attaches itself to more accessible cell receptors called DAF receptors that lie exposed on the upper surface ...

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