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Tag: "assemble" at biology news

Exploring the dark matter of the genome

...hromatin, large, single-copy fragments practically assemble themselves, but it's harder to know how shorter pieces with many repeating sequences, typical of heterochromatin, fit together." Thus the first "substantially complete" genome sequence of Drosophila, published in Science in March, 2000 by the Ber...

Surprising origin of cell's internal highways

...a-tubulin, polymerize into long chains, which then assemble into long, hollow tubes. In order to gain a foothold, nascent microtubule "seeds" must be anchored at a structure near the cell's nucleus called the centrosome or microtubule-organizing center (MTOC). From the MTOC, the growing microtubules launc...

Anthrax paralyzes immune cells with lethal toxin, UF research shows

...ult, immune cells never receive the green light to assemble the actin motor, Southwick's findings demonstrate. "Together, these studies provide important clues about how anthrax escapes the immune system during infection," said Nick Duesbery, Ph.D. deputy director for research operations and senior scienti...

Major gene study uncovers secrets of leukemia

...s differentiated B lymphocytes that have failed to assemble the right genes to make effective antibodies against the specific target they are supposed to attack. However, if these defective B lymphocytes do not differentiate because of the mutations, the body will not recognize them as defective immune cells ...

Bacterial walls come tumbling down

...ir findings help reveal how the enzyme prepares to assemble the bacteria's sugar-coating by plucking sugars from a fat-sugar package known as lipid II. The antibiotic, which is another kind of sugar-lipid, probably mimics the lipid II molecule by tucking into a fold in the enzyme and taking up the space neede...

Darwin's famous finches and Venter's marine microbes

... overlapping sequences, computer programs can then assemble longer stretches and merge them into longer pieces of a genome. These so-called "scaffolds" are a treasure trove for a diverse group of scientists, who try to squeeze as much information as possible from the largest metagenomic dataset ever collected...

Notorious cancer gene may work by destroying messenger

...NAs), molecules that carry the information used to assemble a protein. That work showed that PMR1 attaches to the mRNAs and remains there as a silent passenger. If it receives the proper signal, however, the protein chops up and destroys the mRNA, which instantly stops production of that protein. Cell...

New synthetic self-assembling macromolecules mimic nature

...n scientists devise new ways for molecules to self assemble into new materials, it is an important achievement. Researchers with the Macromolecules and Interfaces Institute (MII www.mii.vt.edu ) at Virginia Tech report such a development in the online issue for the Journal of the American Chemical Society, ...

Selecting life: Scientists find new way to search for origin of life

...s. How were specific kinds of organics selected to assemble into the first forms of life, and by what process were they sufficiently concentrated to initiate a primitive version of metabolism? We now know that minerals select specific organic compounds out of solution, and can even distinguish between subtle ...

RNA map provides first comprehensive understanding of alternative splicing

...come of the how the splicing machinery was able to assemble in a manner that again conformed to the prediction...other it enhanced the ability of this machinery to assemble the right way and use an alternatively spliced site that is otherwise poorly utilized. By offerin...

Proteins may behave differently in natural environments

...ers and the science of computational biology, they assemble tens of thousands of such images into three-dimensional models that demonstrate the dynamics of the proteins. When Ludtke and his colleagues followed this procedure with the GroEL mutant with its sister-protein, GroES, they were surprised. Two of ...

Researchers make nanosheets that mimic protein formation

...e discovered a way to make nanocrystals in a fluid assemble into free-floating sheets the same way some protein structures form in living organisms. "This establishes an important connection between two basic building blocks in biology and nanotechnology, that is, proteins and nanoparticles, and this is ve...

Engineer ramps up protein production, develops versatile viral spheres

...hey are formed when 180 copies of the same protein assemble into a nanoscale soccer ball. "We think these little spheres, 27 nanometers in diameter, will form the basis for a new class of pharmaceuticals and a new class of materials," Swartz says. "For example, to date we've been seriously limited in our ab...

New engineered drug may offer prolonged arthritis relief

...ody temperatures. The combined drug likewise would assemble into clumps in the body to serve as "drug depots" ...lution reach a certain threshold temperature, they assemble into protein aggregates. Study collaborator Ashutosh Chilkoti, a professor of biomedical engineering...

Singing for survival

...e social challenges. "Not unlike humans, gibbons assemble a finite number of call units into more complex structures to convey different messages, and our data show that distant individuals are able to distinguish between different song types and understand what they mean. This study offers the first evide...

MIT nanoparticles may help detect, treat tumors

...ngineering and Computer Science (EECS). "When they assemble they should get stuck inside the tumor and be more visible on an MRI. This might allow for noninvasive imaging of fast-growing cancer 'hot spots' in tumors." Bhatia also is affiliated with the MIT-Harvard Center of Cancer Nanotechnology Excellence. ...

Ghost protein leaves fresh tracks in the cell

...- trying to learn what cues tell spectrin where to assemble in cells. They use the fruit fly as their test animal because its genetic makeup has many striking similarities to humans. "In our study, we showed spectrin doesn't have to bind to ankyrin to do its job," said Dubreuil. "This hints at a complexity ...

Bacteria could make new library of cancer drugs that are too complex to create artificially

...synthesis, with the synthetic power of biology, to assemble complex and synthetically difficult structures. It could be particularly valuable for generating analogues of streptorubin B with all the promise that holds for the development of new anti cancer drugs"...

Researchers discover how bacteria sense their environments

...ural and Molecular Biology, reveals that receptors assemble into a kind of cooperative lattice on a bacterium's surface to amplify infinitesimal changes in the environment and kick off processes that lead to specific responses within the cell. "Bacteria sense a lot of different things. But assume it's a suga...

Trials for new drug to overcome HIV

...thin cell. Others disable protease, which helps to assemble the virus into particles that infect other cells. Recent experiments in collaboration with Michael Sakalian and his colleagues at the University of Oklahoma Health Sciences Center in Oklahoma City have shown that PA-457 works in a different way. It ...

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