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Tag: "arthritis" at biology news

Genetic defects give the immune system the green light to attack the pancreas

...as type 1 diabetes, multiple sclerosis, rheumatoid arthritis and others. To understand what happens in type 1 diabetes, the researchers combined a unique set of cutting-edge technologies, using cultures of thymus cells from transgenic mice, together with DNA chips and “genome scans.?They compared non-obese di...

NHGRI targets 12 more organisms for genome sequencing

...scular studies; the DA strain, used for studies of arthritis and cancer; and the SHR strain, used in studies of hypertension. "The overriding goal of sequencing the genomes of a diverse set of organisms is to understand the biological processes at work in human health and illness," said NHGRI Director Francis...

Disabling gene defuses rheumatoid arthritis in mice

...odifying its activity may be a useful approach for arthritis therapy even when the disease is already well unde...joint and muscle pain. In severe cases, rheumatoid arthritis can damage cartilage, tendons, ligaments and bone, leading to joint deformity and instability. Rheu...

New understanding of cell movement may yield ways to brake cancer's spread

...t halt cancer metastasis and immune disorders like arthritis and asthma. "Previous studies by us and others have identified how a migrating cell 'gets its wheels' and, mechanistically, is able to move. In this study, we have now determined how these wheels become pointed in the right direction", said Vuori. "...

Enzyme's newly discovered role may make it target for arthritis treatment

...ults to refer to. Pham's lab uses mouse models of arthritis to study the contributions of proteases and other .... "This leads to a condition similar to rheumatoid arthritis in the mice." Three years ago, Pham's lab published results showing that mice deficient in cathepsi...

Study finds adult stem cells can replicate

...ults to refer to. Pham's lab uses mouse models of arthritis to study the contributions of proteases and other .... "This leads to a condition similar to rheumatoid arthritis in the mice." Three years ago, Pham's lab published results showing that mice deficient in cathepsi...

Arthritis: What Wnt wrong?

...tributes to disease progression of both rheumatoid arthritis and osteoarthritis. The article by Nakamura et al....f the entire Wnt gene family in the progression of arthritis has been lacking until now. Researchers at Shinshu University School of Medicine in Nagano, Japan, ...

Fundamental discovery -- Bone fracture

...d heart disease can kill you but bone fracture and arthritis make you miserable," he said. "Once a serious bone fracture occurs, then quality of life goes down. Less than one-third of elderly women who have a hip fracture return to previous function. More women die within a year of hip fracture than die after ...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

Gene therapy for arthritis and other non-terminal, debilitating conditions an...erent genes and with different targets, and in the arthritis trial, the transduced cells were removed after one week during routine joint replacement surgery. No...

UQ scientists break new ground in fight against infection & chronic disease

...d to acquire chronic inflammatory diseases such as arthritis and inflammatory bowel disease. They are also behind the muscle wasting experienced by patients with cancer. Chronic inflammatory disorders are a substantial burden in social and economic terms for the Australian community. Arthritis alone afflic...

Stroke treatment a step closer after trial

...ry. IL-1ra is currently used to manage rheumatoid arthritis but, as a long-term treatment, the cost is prohibitive. With stroke, the drug would have to be administered within the first few critical hours through an infusion over a short period of time, perhaps as little as three days. Dr Tyrrell, who is base...

Synthetic Protein Eases Arthritis Symptoms in Mice

...tein alleviates symptoms of both acute and chronic arthritis in mice and could be the basis for a new arthritis drug for people, report scientists from the National Institute of Allergy and Infectious Disease (NI...

Molecular research suggest shift needed in how some drugs are created

...ng pathway, which would be beneficial for treating arthritis and reducing inflammation, said Nair, who also is a researcher in the Center for Biophysics and Computational Biology at Illinois. Signaling in the pathway uses protein molecules that contain death-domains. "What our structure tells us is that the p...

Scientists directly view immune cells interacting to avert autoimmunity

...body's own tissue -- the cause of type 1 diabetes, arthritis and other autoimmune diseases. The scientists showed that Treg cells prevent this destructive response after they and the T helper cells independently interact with dendritic cells. The mechanism of this protective effect remains a major immunology ...

Infection 'alarm' yields clues to immune system behavior

... excessive inflammation associated with rheumatoid arthritis and lupus. In addition, some cancers are more likely to grow where inflammation occurs. These ailments might be helped by a drug that curbs inflammation by reducing the sensitivity of IKK. Still other diseases that are characterized by a weak inflamm...

New drug could reduce tissue damage after heart attack

..., strokes and chronic illnesses such as rheumatoid arthritis and Crohn's disease. CRP levels also rise dramatically after a heart attack. Patients with the greatest and most persistent increases in CRP concentration suffer higher mortality, and CRP is always deposited in and around the damaged heart tissue. ...

Study in Science holds promise for a new approach to drug therapy

...nflammation as they do in patients with rheumatoid arthritis or heart disease. While M119 did block the action of an enzyme involved in inflammation (PI3kinase), it did not block related signals necessary for basic cell function. In addition, M119 was shown to block activation of phospholipase C, which play...

Brain differences could explain why males and females experience pain relief differently

... Chronic pain from inflammatory conditions such as arthritis and fibromyalgia are the most prevalent and pervasive forms of chronic pain. Clinical evidence suggests that women are much more likely to experience chronic forms of pain than are men and that women report feeling more pain than men following vari...

Two NIH initiatives launch intensive efforts to find roots of common diseases

...h on the causes of common diseases such as asthma, arthritis and Alzheimer's disease. One initiative boosts funding at the National Institutes of Health (NIH) for a multi-institute effort to identify the genetic and environmental underpinnings of common illnesses. The other initiative launches a public-priva...

A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases

...litating diseases like inflammatory bowel disease, arthritis and multiple sclerosis, according to researchers f...found in diseases like inflammatory bowel disease, arthritis and MS." IL-25 can be considered a "good" cytokine by limiting chronic inflammatory responses. At ...

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