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Tag: "arteries" at biology news

Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke

...ke. The team blocked blood flow in one of the main arteries feeding specific areas of the brain in mice lacking the gene for the EP1 receptor and then restored blood flow after 90 minutes. The area of brain damage (infarct size) in the mice lacking the EP1 gene was only about 57 percent of that seen in normal...

Researchers show how air pollution can cause heart disease

...rta--mice on normal diets and exposed to PM2.5 had arteries 19.2 percent filled with plaque, the fatty deposits that clog arteries. The arteries of those breathing particle-free air were 13.2 percent obstructed. Among high-fat diet mice, those e...

Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

...with significantly lower restenosis in the carotid arteries of animals with the experimental stents, compared to control animals with conventional, polymer-coated stents. The researchers used a therapeutic gene that encodes for a protein, inducible nitric oxide synthase (iNOS), in the carotid artery studies,...

Feds give researchers ok for safety test of adult stem cells in patients with heart disease

...rrow stem cells at varying doses into the coronary arteries of patients suffering chronic ischemic coronary ar...e, a condition in which one or more of the primary arteries supplying blood flow to the heart are clogged. The study will include patients who are not candidat...

Genetic key to growth of new arteries is identified

...ered part of the genetic mechanism that causes new arteries to grow in response to blocked arteries. A team l...t the MMP2 gene is essential for the growth of new arteries when the femoral (leg) artery is blocked. The team also identified and described, for the first ti...

Researchers develop portable 'vein finder' for faster, more accurate injections

...termine the direction of blood flow to distinguish arteries (which carry blood away from the heart) from veins (which carry blood to the heart). Once the device detects a vein, an alarm is triggered, and medics insert the needle. The vein finder has proved highly effective in initial tests on phantom tissue...

Intensive statin therapy may partially reverse plaque build-up in arteries

...iny ultrasound probe is inserted into the coronary arteries to measure plaque. The study showed that regression occurred for all three pre-specified IVUS measures of disease burden. The mean baseline LDL cholesterol of 130.4 mg/dL dropped to 60.8 mg/dL in the study patients, an reduction of 53.2 percent. Th...

Potential heart benefit found in stem cells

... with ischemic cardiomyopathy, or blockages in the arteries leading to the heart infarction. In the study, 17 patients with ischemic cardiomyopathy were treated with a combined percutaneous injection (both intramyocardial and intracoronary, either the heart muscle or the heart's artery) of bone marrow-derive...

Nearly half of people who need cholesterol treatment don't get it

...10-year risk of developing disease of the coronary arteries was calculated, and they were classified as being low risk, moderate risk or high risk. "We found that cholesterol disorders were common in this population that is free of known cardiovascular disease," said Goff. "And we found that cholesterol tre...

Blood flow in brain takes a twist, affecting views of Alzheimer's

...in mice show that signaling from astrocytes causes arteries in the brain to expand, bringing about an increase in blood flow. "When we measure blood flow," said Nedergaard, "it may be that we are not measuring the activity of neurons so much as that of astrocytes." The idea creates a "chicken or egg" type q...

How nice, brown rice: Study shows rice bran lowers blood pressure in rats

...d class of drugs called ACE inhibitors dilates the arteries of hypertensive patients and thus decreases their risk of stroke, heart attack and kidney disease. But the drugs can also carry side effects: chronic cough, allergic reactions, dizziness, even kidney problems. What if some component of our diet coul...

Viagra improves high altitude exercise performance up to 45% for some

...d the decline of arterial oxygen saturation of the arteries when the cyclists were at simulated altitude of 12,700 feet. But the researchers discovered that these improvements occurred largely because some people achieve major gains with sildenafil at altitude while others improve much less or not at all. T...

Internal body clock dictates timing of different types of stroke

...hat cerebral infarction, where blood flow to brain arteries is restricted, was the most common type of stroke....ubarachnoid haemorrhage, where bleeds occur in the arteries at the brain's surface, was the least common type at 18 per 100,000 of the population. Intracerebral...

New GI technologies improve internal organ visualization

...ures and interventions into the heart and coronary arteries in six pigs and two human patients. Endoscopic ultrasound (EUS) is frequently performed with a scope to visualize and detect abnormalities in the GI tract. Using EUS to guide them, researchers punctured the myocardium and aortic valve or coronary ...

Adult stem cell research at UB targets damaged hearts

...n extended period of time due to narrowed coronary arteries adapt to this deprivation by down-regulating metabolism while remaining functionally viable. Previous work in UB's Center for Cardiovascular Research employing the center's novel swine model of hibernating myocardium has shown that restoring normal...

Scientists work to identify genes that contribute to early heart attack risk

...osclerosis is the development of fatty deposits in arteries that leads to blood clot formation, angina, heart attack and stroke. This process can begin in childhood and early adult life. Doctors have known that genetic factors contribute to risk for early atherosclerosis but the exact genes involved are not y...

A new jump start for aging blood vessels

...ffects. Lastly, administration of TNFa to young arteries reproduced the features of vascular aging, such as blood vessel dysfunction and cell death, further confirming the role of TNFa in the aging of the cardiovascular system. The knowledge that cardiovascular disease is the leading cause of death for ...

High hourly air pollution levels more than double stroke risk

...h effect was found for ischaemic stroke, where the arteries in the brain become furred up and narrowed as a result of fatty deposits. This is possibly because the time lag between the start of this type of stroke and death is rather longer than that for a bleed into the brain, say the authors. Pervious res...

Therapeutic role found for carbon monoxide

...r of Surgery at Harvard Medical School. Pulmonary arteries ?the blood vessels that carry blood from the heart's right ventricle to the small arteries in the lungs -- are made up primarily of endothelial cells and smooth muscle cells. PAH develops whe...

Fast test for low blood flow in dogs detects early heart trouble

...s with drugs therapies, surgical bypass or stented arteries have worked to improve blood flow." Lardo, a bio...ed of blood flow through the heart and its feeding arteries and made separate calculations for each of the organ's three major regions: the front, back and side...

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