Biased reporting found in cancer prognostic studies
...r more transparent reporting, better study design, appropriate analysis methods, more complete data collection, a requirement to make all data available, funding for collecting and annotating data, as well as a needed cultural change within the field of tumor marker research. Citations: # Article: Kyzas PA, Loi...Gap-climbing fruit flies reveal components of goal-driven behaviors
...les in their physical environments and must engage appropriate decision-making and motor skills to deal with them. Navigating these obstacles can involve highly complex events in mammals and other vertebrates, but in new work, researchers have employed an ingenious obstacle-based system for studying the control ...Crisis in African fish supplies looms, experts warn Africa leaders
...as the potential to grow. Regional cooperation and appropriate national policies can provide a major market stimulus and reinforce national and regional food security. 5. Support decision-makers with information Changing fish market structures, supplies and prices will have an impact on food availability an...Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
...as the potential to grow. Regional cooperation and appropriate national policies can provide a major market stimulus and reinforce national and regional food security. 5. Support decision-makers with information Changing fish market structures, supplies and prices will have an impact on food availability an...Duke Experiments Boost Radiation's Cancer-Killing Effects
...s," said Dewhirst. "But when we block HIF-1 at the appropriate time, it substantially increases a tumor's response to radiation therapy." Specifically, they found that blocking HIF-1 immediately after radiation prevented new blood vessels from developing and nourishing cancer cells that survived radiation. Two ...IBM Transforms the Art of Scientific Expeditions
...s," said Dewhirst. "But when we block HIF-1 at the appropriate time, it substantially increases a tumor's response to radiation therapy." Specifically, they found that blocking HIF-1 immediately after radiation prevented new blood vessels from developing and nourishing cancer cells that survived radiation. Two ...Researchers find molecule that inhibits regrowth of spinal nerve cells
... nerves and guide them along the pathways to their appropriate connections to muscles. In 2002 Dr. Mark Henkemeyer, associate professor in the Center for Developmental Biology and of cell biology and one of the authors of the PNAS study, found that such a "fence" is erected specifically down the middle of the c...Results of world's first gene therapy trial for arthritis show approach safe, feasible
...ient population, the ex vivo protocol was the most appropriate approach to take at the time," stated Paul Robbins, Ph.D., professor of molecular genetics and biochemistry and orthopaedic surgery at the University of Pittsburgh School of Medicine, who was the study's co-principal investigator and then director of...Researchers Create DNA-Based Sensors for Nano-Tongues and Nano-Noses
...ors with different response characteristics and an appropriate pattern recognition program would be able to identify a weak known odor in the face of a strong and variable background. "There are few limits as to what we could build these sensors to detect, whether it is a molecule wafting off an explosive devic...Sensor web simulation investigates technique to improve prediction of pollution across the globe
...ansmit that information to decision makers so that appropriate alerts can be issued to those people living in the impacted areas. To test the value and benefit of using dynamic sensor web measurement techniques and adaptive observing strategies, NASA technologists have formulated experiments involving two NASA ...Environment, not genes, key in family relationships
...is and of the details of such a process must await appropriate longitudinal studies." "While these findings in themselves have no immediate practical implication," he continued. "But they should help guide future research into the important question of how children's genes help shape family interaction systems....Optimizing cell therapy against tumors is a balancing ACT
...mors. One of the challenges faced is selecting the appropriate T cells with proper antigen specificity. In a new study appearing in the June 1 print issue of The Journal of Clinical Investigation, Nicholas Restifo and colleagues identified which cells are optimal for treating large, vascularized, established tu...UT Southwestern researchers discover master switch in cell death
...?known as apoptosis ?occurs when it kills cells at appropriate times, as is the case, for example, when it removes the webbing from the fingers of an embryo or shapes a developing brain. But the darker side of this complex process manifests itself in cancers when cells don’t die when they’re supposed to. The ke...'License to kill' enables powerful immune attack cells in mice
...cialized meanings in immunology that really aren't appropriate for this unique process we've discovered," says Yokoyama, who is a Howard Hughes Medical Institute Investigator and chief of the Division of Rheumatology at Barnes-Jewish Hospital. "Many of these terms refer to processes with a similar outcome--impro...MicroRNAs have shaped the evolution of the majority of mammalian genes
...ites necessary for turning down these genes at the appropriate place and time." An emerging idea is that microRNAs often act to reduce the quantity of protein a gene produces without shutting it off all together. "We think the microRNAs are sometimes having what you can call a dampening effect," says Bartel, w...Biotechnology's newest chemical tool
...otein production -- with bright fluorophores using appropriate RNA methyltransferases, enabling real-time dynamic studies of the complicated mechanism of protein translation. ...Researchers find gland that tells fruit flies when to stop growing
... signals when it senses the fly has reached a size appropriate to enter adulthood. The scientists found they could use the pathway that sends insulin to a fly's cells to genetically manipulate the size of the prothoracic gland, part of a more complex structure called the ring gland, and send false signals about...Scientists must offer solutions for conserving tropical forests in a rapidly changing world
...cies and over two-thirds of all people. Without an appropriate commitment from the scientific community, the two are unlikely to continue to coexist," concludes the scientist. Tropical forest landscapes are changing rapidly in the eyes of scientists working on tropical monitoring plots around the globe, while h...Mouse genome much more complex than expected
... If the body is to produce a specific protein, the appropriate page of the encyclopedia is copied (rewritten or 'transcribed'). Only the copies can leave the cell nucleus. They consist of a DNA-like material known as mRNA. Each mRNA contains the blueprint for precisely one specific protein ?this at least has bee...Reducing antibiotic use lowers rates of drug-resistant bacteria
...formation campaign about antibiotic resistance and appropriate antibiotic use. A control group of children and their doctors received no specific information about antibiotic use. The study was conducted from January through May of 2000. By the end of the study, antibiotic use had declined by more than 15 perce...