Abnormal overexpression of p53 is a predictive molecular biomarker
...and has been granted fast track designation for an application of use in head and neck cancer. Results from two phase II clinical trials involving more than 160 SCCHN patients have found that 18 percent of patients treated with Advexin achieved local regional disease control. Two other phase III trials in the di...Cardiologist's 'living chip' changes science of disease monitoring
...ssens the chance of a hospital stay. The initial application for this technology is expected to involve pharmaceutical companies, which could use the biological chips to test potential drugs in the lab more quickly and accurately. In later generations, the chip ultimately could command implanted devices ?for e...Three-dimensional, miniature endoscope opens new diagnostic possibilities
...gh-definition images, which may greatly expand the application of minimally invasive diagnostic and therapeutic p...imensional images. To demonstrate the device's application in a live animal, the researchers used the system to image metastatic ovarian tumors on the abdomina...Researchers examine why food tastes bad to chemotherapy recipients
...ing of the metallic sensation, its prevention, and application to human health," Dietrich said. Along with two of her university colleagues, Susan E. Duncan, professor of food science and technology, and YongWoo Lee, an assistant professor in the biomedical sciences and pathology department and a member of the...Study offers innovative profile of enzyme that aids tumor growth
... directly in living systems through the integrated application of profiling technologies that survey both the enzymatic proteome and its primary biochemical output, the metabolome," Cravatt said. So, the team drew both on proteomics-the large-scale study of the structure and function of proteins-and metabolo...On the golf tee or pitcher's mound, brain dooms motion to inconsistency
...s to help pitchers throw more strikes. A potential application of the research, Shenoy says, could come in future efforts to achieve new kinds of computing by building artificial circuits modeled on the brain. But Shenoy says the research simply set out to explain variability in movement. "This is basic scienc...UNC scientists solve mystery of how largest cellular motor protein powers movement
...yan said. While the research offers no immediate application to human disease, the authors noted that mutations of dynein have been implicated in some neurodegenerative and kidney disorders. Dokholyan pointed out that disruption of dynein’s interaction with a particular regulator protein causes defects in nerv...A giant among minnows: Giant danio can keep growing
...cle fiber to repair the injury. There is also an application to fish farming. “If we understood how fish grow, we could figure out strategies for enhancing the growth of farmed fish such as Atlantic salmon and decrease the time to get to market size. “The more we understand about growth, the more likely we can......iderable need for research. Moreover, the clinical application of gene therapy requires careful risk/benefit assessment, although in this respect it does not differ substantially from other therapeutic approaches. Gene therapy is defined as the introduction of genes into tissues or cells via gene transfer, with...Most widely used organic pesticide requires help to kill
...n. The upshot of the new work may have immediate application in designing strategies to manage insect pests by ...mediate the effects of bacterial toxins could have application in human and animal medicine as the roles of those bacteria become better understood. Bacterial infe...Three-in-one virus killer prevents common, often fatal infections
...virus." Bollard envisions one day extending the application of CTLs to other people with compromised immune systems, such as cancer patients undergoing chemotherapy. The therapy could also potentially be used in babies, who are more susceptible to adenovirus infections than other age groups. ......clean expansion" of HSCs holds great potential for application in human transplant recipients. ...Iowa State researchers improving plastics made from corn and soy proteins
...ng hold and expanding every day." Sam Senti, an application specialist for Vibroacoustics Solutions Inc., said the company would like to use biorenewable and biodegradable plastics in a stick lubricant it has developed. The bio-based lubricant rubs off on metals ?it, for example, can be used to help locomotiv...3-D ultrasound scanner could guide robotic surgeries
...ly guide a surgical robot. The scanner could find application in various medical settings, according to the rese...procedures," Pua added. "Our results show that the application of real-time 3-D ultrasound to these surgical procedures may increase information available to the s......y, is a promising area of scientific research with application in the treatment and cure of a rapidly expanding list of diseases and injuries. Scientists believe cell-based therapies could be used to repair damaged heart muscle following a heart attack, replace skin for burn victims, restore movement after a sp...New technology enables faster, more efficient cell harvest: Cell therapy meeting study
...y, is a promising area of scientific research with application in the treatment and cure of a rapidly expanding list of diseases and injuries. Scientists believe cell-based therapies could be used to repair damaged heart muscle following a heart attack, replace skin for burn victims, restore movement after a sp...New strategy developed to combat West Nile Virus
...e it easier to devise control strategies. Chemical application is the most likely scenario, but because it could be applied in selected areas, it would be more cost-effective and potentially less environmentally threatening." The spread of West Nile Virus through the U.S. has been sporadic, the researchers say...Patients to benefit from novel technology revolutionizing high-speed molecular imaging
...plications for the D-SPECT camera. "The first such application will be in cardiac perfusion (blood flow to the heart), and a multicenter study is planned for the second half of this year," said Patton. Vanderbilt University Medical Center will be among the first four sites to experiment with the imaging camera, ...Interfering RNA silences genes in 'slippery' immune cells
...t HIV infection, the new technique has a potential application to HIV treatment. "The siRNA may represent a suicide vector: by knocking down HALP it may allow HIV-infected cells to self-destruct, thus eliminating a hiding place for the virus," said Dr. Finkel. "More broadly," she added, "the technique could t...Report focuses on the role good microbes play in future medicine
...rces, eventually crowding them out. One potential application of competitive exclusion would be colonizing the mouth with beneficial bacteria to prevent the growth of bacteria that cause cavities and gum disease. Probiotics also help prevent disease by interacting with and strengthening the immune system. "...