Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
...of the neural pathway used by hormones to regulate appetite and eating behavior could eventually provide new drug targets for treating eating disorders and obesity. The research, reported on-line April 9 in the journal Nature Medicine, will be published in the May 1 print edition. The hypothalamus serves a...Dogs keep dying: Many owners unaware of toxic dog food
...een poisoned by afltoxin include lethargy, loss of appetite and vomiting and, later, orange-colored urine and jaundice (a yellowing of the eyes, gums and nonpigmented skin that reflects substantial liver injury). Severely affected dogs produce a blood-tinged vomit and bloody or blackened stools. "Since dogs c...Study by Einstein researchers could lead to a novel strategy for treating obesity
... latest finding on the brain's role in controlling appetite and weight, researchers at the Albert Einstein College of Medicine have shown that reducing levels of fatty acids in the hypothalamus causes rats to overeat and become obese. Their results suggest that restoring fatty-acid levels in the brain may be ...Access to existing medical treatments could save more lives than spending to improve the treatments
...mmercial interests of industry and by the public's appetite for technological breakthroughs, but health outcomes ultimately suffer." The authors discuss the relevance of this concept at a time when the nation is struggling with the escalating costs of health care and unsatisfactory performance on quality. "H...An essential regulator of body weight revealed
...s from POMC neurons ?suggesting it could stimulate appetite through a mechanism unique from that of NPY. It seemed to be the molecule they'd been searching for. "We thought, this is great: NPY is gone, AgRP takes over ?how simple could it be?" Palmiter said. But when scientists at Merck created mice that lack...Weight control protein may yield antiobesity drugs
...tent. That signal, in turn, elicits adjustments in appetite and energy expenditure to maintain normal body weight. Mice lacking SH2-B overeat and become obese, the team found. The animals additionally develop a metabolic syndrome characterized by high blood concentrations of leptin, insulin, and lipids. They......to stress, pain, and the physical drives of sleep, appetite and sexuality. A better understanding of such fundamental mechanisms of neurotransmitter release will aid researchers in their investigations of psychiatric disorders and neurological disorders such as mental retardation, autism, depression and epil...