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Tag: "apoptosis" at biology news

Cells re-energize to come back from the brink of death

... once by disabling the main suicide pathway called apoptosis can also foil a backup self-destruct program, whic...y’s senior author. MOMP triggers apoptosis, but if apoptosis fails because there is no caspase available, the backup program called caspase-independent cell deat...

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

...nduce the activation not only of genes involved in apoptosis but also of many other genes that encode for proteins involved in different aspects of the atherosclerotic process (lipid metabolism, inflammation, adhesion molecules, etc.). For the first time, the study shows that one of these proteins is very impo...

Gene thought to assist chemo may help cancer thrive

...l can't be repaired, p53 starts a process known as apoptosis that kills the cell. It's p53's role as one of the genes involved in initiating cell death that has led cancer researchers to long believe that the gene is essential to successful chemotherapy. The idea is that p53 assists in killing the cancerous ce...

Scripps research study shows humans and plants share common regulatory pathway

...llular signaling pathways, cytokine production and apoptosis or programmed cell death. Despite the fact that various models of Nod1 activation have been described, little has been known about other proteins that might affect the protein’s activation. In contrast, a number of additional proteins have been linke...

Veterinary scientists explore poultry virus as cancer killer

...o the death of the cancer cell by a process called apoptosis - also known as programmed cell death or cell suicide- in the cell. ...

Cancer-killing invention also harvests stem cells

...surface, King's device captures it and delivers an apoptosis signal, a biochemical way of telling the cancer ce...e device selectively targets cancer cells. The apoptosis signal is delivered by a molecule called TRAIL that coats the cancer-killing device. Cancer cells h...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...tumor development by inducing cell-cycle arrest or apoptosis via a complex signal transduction network referred...-MDM2-LANA complex and selectively induces massive apoptosis in PEL cells. The cytotoxic effect of Nutlin-3a was specific for the KSHV-infected cells since Nutli...

Dual gene therapy suppresses lung cancer in preclinical test

... combination had 2 to 3 times more cells killed by apoptosis than either gene nanoparticle had individually. The research team then confirmed these findings in the mouse studies. The nanoparticle delivery system, which the researchers have used for years, consists of a plasmid gene expression cassette loade...

HIV protein enlisted to help kill cancer cells

...rch team found that the TAT-Bim compound activated apoptosis mechanisms in cancer cells and augmented the cell-... Hawkins says he thinks treatments that activate apoptosis mechanisms could provide new options for patients with the deadliest cancers ?such as pancreatic can...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...ressed in tumors after treatment. FUS1 can induce apoptosis - programmed cell death - in cancer cells but is ...r in the field of gene therapy. FUS1 can induce apoptosis - programmed cell death - in cancer cells but is absent in those cells. The FUS1 nanoparticle formu...

Tumor cells evade death through autophagy

...mpson and colleagues show that in a tumor in which apoptosis was induced by activation of p53 expression, autop...phagy, increased numbers of tumor cells undergoing apoptosis were detected. Furthermore, if these mice were treated with the chemotherapeutic agent cyclophospham...

Reactivated gene shrinks tumors

... the white blood cells, the cancer cells underwent apoptosis within 1 or 2 days of the p53 reactivation. In... (which affect connective tissues) did not undergo apoptosis but went into a state of senescence, or no growth. Those tumors took longer to shrink but the senesc...

St. Jude announces breakthrough in eye cancer treatment

...erturned a widely held belief about the process of apoptosis (cell suicide) in retinoblastoma. Apoptosis is the... that a mechanism called the p53 pathway triggered apoptosis in other types of cancer cells, but not in retinoblastoma. However, the St. Jude team proved not onl...

A valuable fly for research into disease

...m the Universidad Autónoma de Madrid, will address apoptosis and tumourous transformation. Heart disease is another topic that has recently been added to the list of diseases studied using Drosophila. Rolf Bodmer, from The Burnham Institute in the US, has begun to use this model to study arrhythmias and heart...

Key gene controlling kidney development found

...rthermore, the remaining precursor cells underwent apoptosis (cell suicide), further depleting the population of stem cells that could give rise to differentiated cells needed to form the kidney. The researchers also found that Six2 works by suppressing a cascade of genetic interactions normally triggered by...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...ide expression, curbing proliferation and inducing apoptosis in human lung cancer cells. They tested CDDO-MA...effective in inhibiting proliferation and inducing apoptosis (programmed cellular death, a process that's often disrupted in cancer) in breast cancer cells, and ...

Hope for a more effective and less toxic cancer drug

... healthy process called programmed cell death - or apoptosis - to ensure that unwanted cells die on cue. If this process fails, then the damaged cells live on and multiply indefinitely and uncontrollably. This uncontrolled multiplication of rogue cells can lead to cancer. Conventional chemotherapeutic drugs...

PNAS study reveals why organs fail following massive trauma

...e genes and proteins involved in T cell anergy and apoptosis amid this storm has been a challenge. Researchers took blood samples from 22 healthy subjects, and from 18 consenting patients who had experienced severe trauma, and were in the midst of organ failure. The team then used unique, clinically applicab...

Targeted virus compels cancer cells to eat themselves

... The cells showed no sign of having been killed by apoptosis -- a much better known process of programmed cell ...chanism that systematically kills defective cells, apoptosis is suppressed or dysfunctional in cancer cells. Many cancer therapies focus on restoring or enhancin...

University of Minnesota researchers take new look at cellular suicide

... toes. By contributing to the understanding of how apoptosis works, the researchers, led by Zigang Dong of the ...s. The histone H2AX is probably important for both apoptosis and DNA repair." Dong and his colleagues were led to the discovery by their previous work on the bi...

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