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Chemists create 'Superbowl' molecule; May lead to better health

...ecule will actually enter the consumer market, but any useful application is likely to take five to ten years, the researcher estimates. Administration of the molecule for drug delivery could be by mouth or by injection, he adds. There are hurdles to overcome. The current version of the superbowl molecu...

DNA Molecules Used To Assemble Nanoparticles

... of molecules---drugs, contrast agents---to almost any cell," said Dr. James R. Baker Jr., the Ruth Dow Doan Professor of Nanotechnology and director of the Center for Biologic Nanotechnology at U-M. Nanoparticle complexes can be specifically targeted to cancer cells and are small enough to enter a dise...

Wisconsin scientists grow critical nerve cells

...ability to replicate indefinitely and develop into any of the 220 different types of cells and tissues in the body. But researchers have struggled to convert blank-slate embryonic stem cells into motor neurons, says Zhang. The goal proved elusive even in simpler vertebrates such as mice, whose embryonic...

Association of herpesvirus with lung disorder questioned

... failed to detect either the antigen or the DNA in any of the 22 samples from the two groups with some form of pulmonary hypertension, whereas the antigen was detected in the control group of Kaposi's sarcoma tissue samples. These data suggest that human herpesvirus 8 infection is not associated with Ja...

A new mechanism of regulating RNA degradation

...even more complex than we first imaginated... As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. Wh...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...even more complex than we first imaginated... As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. Wh...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...ite. "It is unclear at this time whether there are any interventions that could alter DNA repair capacity and what effect such interventions might have on risk." In an editorial, Marianne Berwick, Ph.D., M.P.H., of the University of New Mexico in Albuquerque, and Paolo Vineis, M.D., M.P.H., of Imperial ...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

...gment which will fit exactly. Wecan place cells in any designed position in order to grow tissue orbone."...ctlyinto the structure as it is built. This avoids any 'sticking to thesurface' which is a major disadvantage of current methods that infusethe cells into ...

Dysentery uses 'sword and shield' to cause infection

...dysentery, is able to invade cells, while stopping any response from the immune system. They found that shigella was able to infect cells by using a secretion system to inject proteins into human cells, (the sword), while lipopolysaccharide (LPS) on the surface of the bacteria acts as a shield to protec...

Novel technology detects human DNA mutations

...pecificity and sensitivity. One segment identifies any mutations in the DNA and the probe, a highly sensitive gold nanoparticle, creates a strong signal accurately indicating the presence of a specific target SNP. Proof of principle, reproducibility, and the robust, simple and rapid characteristics of th...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

...tentially increase susceptibility to HIV and limit any protective effect of microbicides." said Betsy Herold, M.D., Professor of Medicine and Chief of Pediatric Infectious Disease at Mount Sinai and the senior investigator on this study. "We are currently conducting a 14-day study to assess whether or no...

Priming embryonic stem cells to fulfill their promise

...er researchers couldeasily use this technique with any other tissue in mouse, or human, orany other speci... number ofpossible combinations of these proteins, any one of which could formthe optimal "niche" for a desired type of differentiated cell.In their experi...

Growth in the sea comes down to a struggle for iron

...ts had recorded the largest phytoplankton bloom of any of the iron fertilization tests conducted to that ... not adding iron to ocean waters is a wise tool in any attempts to manage a changing climate. ...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...ice that were not inbred or genetically altered in any way, they mated females with males, dating the day of their pregnancy, which lasts three weeks. They separated the mothers into two groups. The control group ate as much chow as they wanted during the entire pregnancy. The other group also was fully ...

Neuronal 'traffic jam' marks early Alzheimer's disease

... early in the life of those animals -- well before any plaque deposition -- were obvious axonal defects,"... scale toward disease." Goldstein emphasized that any application of these findings to potential diagnostic tests or new therapies remains speculative at ...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

... made during thelast few years to try to eliminate any animal-derived culturecomponents in human stem cel...mbryonic stem cellsthat have never been exposed to any animal products, and ideally, onlyever exposed to serum from the intended transplant recipient.""How...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...ound forms and try to understand whether there are any immunologic properties that differ and that might provide a route to new vaccine or drug strategies," Harrison says. ...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

... knownas organelles," Holtzman explains. "Normally any given segment of anerve cell branch would have only very small amounts of theseorganelles."Nerve cells move organelles along their branches as a part of theirregular function. Holtzman suspects that this transport breaks down inthe mice, leading to p...

Key molecule in plant photo-protection identified

... knownas organelles," Holtzman explains. "Normally any given segment of anerve cell branch would have only very small amounts of theseorganelles."Nerve cells move organelles along their branches as a part of theirregular function. Holtzman suspects that this transport breaks down inthe mice, leading to p...

Timing is everything: First step in protein building revealed

...can the ribosome start making proteins."No one had any idea when eIF1 was released from the ribosome, or thatits release might serve an important purpose, so this was a completelyunexpected result," says graduate student David Maag, first author ofthe paper."It's impossible to know for sure whether eIF1 ...

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(Date:7/9/2014)... study co-authored by a University of Guelph scientist ... tags shows long-term exposure to a neonicotinoid pesticide ... The research by Nigel Raine, a professor in ... of Imperial College London was published July 9 ... Ecology . , The study shows how long-term ...
(Date:7/9/2014)... announce themselves with pain and fever but often can be ... are sneaky and hard to beat. Now, scientists have built ... tiny DNA pyramids. Published in the journal ACS Applied ... flag bacteria and kill more of them than medicine alone. ... infectious pathogens can lie in wait, undetectable in the human ...
(Date:7/9/2014)... A drug candidate developed by researchers at ... Sciences (NCATS) and its collaborators to treat ... Baxter International,s BioScience business. The drug candidate, ... target the underlying molecular mechanism of sickle ... clinical development activities required for regulatory approval ...
Breaking Biology News(10 mins):Bee foraging chronically impaired by pesticide exposure: Study 2First drug candidate from NIH program acquired by biopharmaceutical company 2First drug candidate from NIH program acquired by biopharmaceutical company 3First drug candidate from NIH program acquired by biopharmaceutical company 4
(Date:7/9/2014)... and poor printing on prescription labels handed out ... to errors in taking medication, according to new ... (Canadian National Institute for the Blind)., The study, ... , found that labels on prescription medications dispensed ... guidelines for legibility. , By simply following recommended ...
(Date:7/9/2014)... published in the scientific journal Nature Neuroscience ... at Universit Laval, reveals that it is possible to ... rekindling pain so that it can subsequently be erased. ... chronic pain. , The researchers from the Faculty of ... mentale de Qubec (IUSMQ) were inspired by previous work ...
(Date:7/8/2014)... cardiovascular health as other healthy mature individuals, according to ... of Transplantation . The findings may provide some reassurance ... caring for them. , Over the past two decades, ... older has become more common. Given the links between ... of a kidney could make older donors vulnerable to ...
(Date:7/8/2014)... clinicians from Plymouth, UK, and Sydney, Australia, have today ... launched ACEmobile - a free-to-use app to support the ... the first of its kind; an iPad-based tool that ... through the whole process, meaning more members of the ... of assessment. Designed by clinicians for clinicians, ACEmobile also ...
(Date:7/8/2014)... discovered a biomarker that could give expecting mothers and ... predict that a pregnant woman may develop preeclampsia, at ... , Preeclampsia is a cardiovascular disorder generally occurring late ... creating immediate and potentially lifelong risks to both mother ... in the urine, and is typically diagnosed in the ...
Breaking Medicine News(10 mins):Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2Health News:Discovery of a new means to erase pain 2Health News:Study finds kidney donation safe for healthy older adults 2Health News:New app widens opportunities for dementia assessments 2Health News:New app widens opportunities for dementia assessments 3Health News:UI researchers find early predictor for preeclampsia 2Health News:UI researchers find early predictor for preeclampsia 3
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