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Tag: "antiviral" at biology news

Mice lacking key immune component still control chronic viral infections

...ackup may become a new focus for efforts to design antiviral vaccines. "This surprising finding contradicts a...fectious agents. Some current efforts to develop antiviral vaccines focus exclusively on portions of viral proteins likely to be picked up and presented by MHC...

New protein target may advance design of HIV and cancer drugs

... processes and proteins are attractive targets for antiviral drug development," said lead author Nicholas Farrell, Ph.D., professor and chair in the Department of Chemistry at VCU and a member scientist with the VCU Massey Cancer Center. According to Farrell, these study findings may also one day be applied ...

Knowledge of infection may prevent spread of herpes virus

...d Leone. The two experts also support suppressive antiviral therapy and condom use as the other necessary elements to control the spread of genital herpes nationwide. This most recent study also found that most people who transmitted HSV did not know that they had genital herpes. Wald, Hook, and Leone sugges...

Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic

...ys, and examines the impact of interventions, from antiviral therapy to school closures and travel restrictions...nd distribute sufficient quantities of vaccine and antiviral drugs," said Germann of Los Alamos' Applied Physics Division. "Based on our results, combinations o...

Hepatitis C therapy: Inhibiting newly discovered microDNA molecule

...s widely heralded for its potential to develop new antiviral agents against hepatitis C, the most common blood-borne viral infection in the United States, affecting more than 2.5 million Americans and a staggering 170 million people worldwide. The best treatment regimens now available are difficult, expensive...

Scientists identify molecular structure of key viral protein

...ratory and systemic disease. "The development of antiviral drugs is helped by knowledge of the structure, shape and mechanism of the target molecules, which is what we can now provide for the F protein," said Theodore S. Jardetzky, professor of biochemistry, molecular biology and cell biology, who co-led the...

Cyclosporine inhibits hepatitis C virus in vitro

...py," the authors report. In addition, they confirm antiviral activity by the drug in cell cultures, having foun...tion of Cyclosporine and interferon achieve better antiviral effect than either one alone." Of note, considerably more patients taking Tacrolimus had to reduce...

Novel virus entry mechanism could lead to new drugs against poxviruses

... virology and paves the way for development of new antiviral drugs. Many viruses, such as influenza, are surr... polyanionic compounds exposes the virus, allowing antiviral antibodies to be more effective. The disruption of the outer membrane also limits the spread of the ...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...ray of HIV mutants, some of which are resistant to antiviral drugs. Drug-resistant strains of HIV are being found more often in recently infected people, indicating that transmission of resistant strains is occurring at an increased frequency. As a graduate student in McCammon's lab, Perryman initially set o...

Computer simulation hints at new HIV drug target

...ray of HIV mutants, some of which are resistant to antiviral drugs. Drug-resistant strains of HIV are being found more often in recently infected people, indicating that transmission of resistant strains is occurring at an increased frequency. As a graduate student in McCammon's lab, Perryman initially set o...

Gene-specific Ebola therapies protect non-human primates from lethal disease

...o the lethal disease. This is the first successful antiviral intervention against filoviruses like Ebola in nonhuman primates. The findings could serve as the basis for a new approach to quickly develop virus-specific therapies for known, emerging, and genetically engineered pathogens. In today's online issu...

Animals can change genes quickly to keep up with viral ingenuity

...id evolution illustrates the vital role of RNAi in antiviral defense, and it shows that these genes can be central players in the evolution of host organisms in response to the ever-changing strategies of viral attacks. ...

Waking a sleeping virus

...s a potential weak point that could be targeted by antiviral drugs. The molecule is a protein called ZEBRA, which the virus brings along as it infects human cells. ZEBRA is essential to switching the virus from its latent to its active state. "During an infection, EBV inserts its own DNA into the nucleus of h...

Medical experts: US unlikely to have enough vaccines to stop avian flu

...ble to manufacture and stockpile enough vaccine or antiviral medication to stop a bird flu pandemic should the ... U.S. will have adequate stockpiles of vaccines or antiviral drugs to prevent a pandemic within the next three years. The same experts gave a median estimate of ...

Immune system response to viral DNA is unique

... self DNA were to break down, cells might mount an antiviral response against their own DNA," he said. "Further... this pathway will shed light on the mechanisms of antiviral responses and how cells discern viral and self-DNA." ...

Mining for gems in the fungal genome

... of bacteria. Fungi are also natural producers of antiviral agents, antifungals, other antibacterials, immunosuppressants and the popular cholesterol-lowering drug lovastatin. Earlier methods to find secondary metabolites located just one compound at a time, and sometimes required prior knowledge about the...

UW scientists unravel critical genetic puzzle for flu virus replication

...nt because it presents opportunities to design new antiviral drugs and harness flu viruses for speedier, more e... assembly opens the door to the development of new antiviral drugs and the harnessing of benign influenza viruses as gene vectors to optimize vaccine production,...

Sweetgum tree could help lessen shortage of bird flu drug

...id, the starting material used to produce the main antiviral agent in a much-heralded drug for fighting bird fl... Some health experts believe that this and similar antiviral drugs could help save lives by slowing the spread of the virus in the absence of a bird flu vaccine,...

The reason why antiviral therapy can't annihilate HIV infection, and what to do about it

...adication of HIV in infected individuals receiving antiviral therapy. The authors focused on HIV-infected patients who had received effective antiviral therapy for extended periods of time and examined the nature of their residual virus as well as the ...

Technique offers new view of dynamic biological landscape

... to use E-MAP to develop effective combinations of antiviral drugs that target proteins produced by interacting genes. Such a strategy would help to prevent these genes from acting together to compensate for an attack on just one protein, said Weissman. The researchers, led by Weissman, Maya Schuldiner, a po...

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