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Tag: "antiviral" at biology news

Researchers seek to design first treatment for neuroAIDS

...ge. Driving their approach is the realization that antiviral drugs that work against AIDS do not cure neuroAIDS...nerable to infection. Before the arrival of modern antiviral therapies in 1996, HIV also had a devastating effect on the brain known as HIV-associated dementia (...

Early HIV treatment fails to restore memory T cells

...t normal levels when HIV infection is treated with antiviral drugs, it has been unclear whether the intestinal mucosal memory cells return as well. By performing intestinal biopsies on volunteers who started HIV treatment shortly after infection, the researchers found that, unlike in blood, intestinal T cells ...

New drug blocks influenza, including bird flu virus

...ant because it could make available a class of new antiviral drugs to prevent and treat influenza at a time whe...r of a global pandemic is heightened and available antiviral drugs are losing their potency. "This gives us another tool," says Stacey Schultz-Cherry, a UW-Mad...

Sea urchin genome suprisingly similar to man and may hold key to cures

...ould very well provide a new set of antibiotic and antiviral compounds to fight various infectious diseases." The sea urchin has been used for many years as a research model to study embryonic development. Cell development is very complicated. In order to properly regulate just one gene expression of a s...

Mayo researchers discover HIV dependence on a human protein

... those copies are "suppressed" with multiple daily antiviral medicines, they are never cured. Stopping the medicines even briefly lets HIV repopulate the body with many millions of copies, like a computer virus spreading around the world from a single infected computer. ...

SARS: No evidence that any of the treatments worked

...ff the virus. However, in recent years a number of antiviral drugs have been developed (for example, there are ...r all the available evidence on the use of certain antiviral drugs (ribavirin, lopinavir and ritonavir), steroids, and proteins called immunoglobulins which are ...

U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication

...es novel insights for developing live vaccines and antiviral drugs for influenza epidemics and pandemics. A pro... virus to cause disease, laying the groundwork for antiviral drug development. "Increasingly, new diseases involve both humans and animals," said Andrew Pott...

Experimental vaccine protects mice against deadly 1918 flu virus

...n for monoclonal antibodies that may be used as an antiviral treatment, according to Dr. Nabel. "This technique would be very useful in defining evolving serotypes of flu viruses like H5N1 to develop immune sera and neutralizing monoclonal antibodies that may help to contain pandemic flu," says Dr. Nabel. ...

Molecular 'on/off switch' controls immune defenses against viruses

...gs that could mimic viral effects on RIG-I to spur antiviral response or, conversely, mimic viral effects on LG..."Fine-tuning immune response to infection is where antiviral or immune regulatory drugs are headed," said Dr. Gale....

Air travel and pandemic flu

.... These measures could include use of vaccines and antiviral drugs if they were available and effective against the virus. ...

Trials for new drug to overcome HIV

...elp overcome HIV�fs growing resistance to existing antiviral drugs is about to be tested in combination with standard antivirals. Called PA-457, it is the first of a new class of anti-HIV compounds called maturation inhibitors. The drug is still in its early stages, and will not be generally available for at l...

Statins stop hepatitis C virus from replicating

... inhibit the replication of HCV RNA via a specific antiviral mechanism," the authors report. The researchers tested the theory that certain proteins are required for HCV RNA replication and that statins block the replication by inhibiting those proteins. In support of this theory, they found that the addition...

New bird flu drug promises to beat the problem of resistance

... inhibitor they have discovered into a new kind of antiviral influenza drug. The search for an alternative flu drug has become all the more pressing as the full extent of resistance ?the ability of the influenza virus to withstand drug treatments - becomes more widely understood. Both Tamiflu and Relenza, ...

Defense peptide found in primates may block some human HIV transmissions

...d cells. HIV-1 often mutates quickly to overcome antiviral compounds designed to prevent infections. But a re...d virus. Viruses that have to defeat more than one antiviral mechanism often develop resistance at a much slower pace. The next phase of Cole's research will d...

Study details hepatitis C ability to block immune system response

...strated that many interferon stimulated genes with antiviral activity are induced in the liver during HCV infec...finitely, indicating that it is resistant to their antiviral effects." The current study sheds light on one strategy the hepatitis C virus uses to resist the im...

Researchers seek to solve mystery of natural HIV control

... the virus with their immune systems alone. Unless antiviral medications are used, the virus continues to repro... viral loads below 2,000 copies without taking HIV antiviral medications. Participation involves having a single blood sample taken, which can be done by partic...

Novel therapy combinations gain ground in treating hepatitis

...atment options. Combination treatment using a new antiviral therapy is showing promise in suppressing the viru...n this study, researchers evaluated the safety and antiviral response of VX-950 in combination with pegIFN and ribavirin (RBV). The study included 12 hepatit...

A new tool against brain disease

... in 71 HIV-infected patients who had not yet begun antiviral treatment. In a separate study, the researchers de... blood samples from four patients before and after antiviral therapy, they found that PD-1 expression dropped when treatment began. "It became very clear from th...

How HIV 'exhausts' killer T cells

... in 71 HIV-infected patients who had not yet begun antiviral treatment. In a separate study, the researchers de... blood samples from four patients before and after antiviral therapy, they found that PD-1 expression dropped when treatment began. "It became very clear from th...

First study to show how immune cells 'speak' to each other in vivo

...ce of mature immunological synapses in vivo during antiviral immune responses. The findings will allow further experimental exploration of immunological synaptic function during normal and pathological immune responses in vivo. The full study can be accessed at www.jem.org . WHY: The mechanism of how...

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