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Tag: "antiviral" at biology news

Blood-brain barrier breached by new therapeutic strategy

... infect the brains of mice. They then injected the antiviral siRNA bound to the rabies peptide through the tail...; in contrast, 80 percent of the mice that got the antiviral siRNA linked to the rabies peptide survived. These experiments demonstrate how the rabies peptide ca...

Ancient retrovirus sheds light on modern pandemic

...e, to the presence of an ancient, rapidly evolving antiviral defense gene called TRIM5a, which produces a prote...e laboratory, the researchers found that the human antiviral protein TRIM5a effectively neutralizes this extinct retrovirus, which never successfully fixed into ...

Experts predict Tamiflu could halve the pandemic influenza death toll versus no intervention

Treatment with the oral antiviral Tamiflu (oseltamivir) and prophylaxis for people e..., some governments are now planning for sufficient antiviral stockpiles that will allow them to provide Tamiflu preventatively to close contacts of infected indi...

Resistant HIV quickly hides in infants' cells

...rides have been made in limiting transmission with antiviral drug therapies before, during, and following birth. In the last few decades the rate of mother-to-child transmission of HIV in the United States has been reduced from 25 percent to its current rate of less than 2 percent. However, the transmission ...

Peramivir protects mice from lethal H5N1 infection

The antiviral drug peramivir might offer humans significant prot...ude Children's Research Hospital. Peramivir, an antiviral drug, blocks the ability of influenza viruses to use an enzyme called neuraminidase, thus preventing...

WHO data confirms low level of resistance to Tamiflu

... Information gathering and results As with any antiviral medication, there is a theoretical risk that a virus may emerge with decreased sensitivity to a drug. The Neuraminidase Inhibitor Susceptibility Network undertook screening for susceptibility to oseltamivir of influenza viruses randomly submitted to...

NIAID expands capability for influenza research and surveillance

...ster) Research activities will involve evaluating antiviral drug regimens and factors that drive drug resistan...tion about circulating influenza virus strains and antiviral drug resistance—information that will be most critical during the early stages of an influenza pande...

Study suggests some drug resistance to influenza B medications

Use of certain common antiviral drugs during a recent influenza B epidemic in Japa...ding to a study in the April 4 issue of JAMA. Two antiviral drugs, zanamivir and oseltamivir, which are a type of drugs known as neuraminidase inhibitors, have ...

Veterinary scientists explore poultry virus as cancer killer

...ells. Normal, healthy cells have an interferon antiviral system that activates upon infection with NDV ther.... Cancer cells, however, have defective interferon antiviral systems, he said. NDV utilizes the defects to replicate in the diseased cells. The replication of ND...

Discovery could lead to better control of hemorrhagic fever viruses

...which is necessary for the development of targeted antiviral drugs that block those parts, but not the parts involved in iron uptake. The findings of Choe and colleagues also suggest that iron supplements may reduce the severity of New World virus infections. Past studies have shown that when the iron leve...

Scientists find potential 'off-switch' for HIV virus

...ent over drug cocktails, which are the mixtures of antiviral agents that have been the best-available treatment for the disease for a decade. "Drug cocktails extend the life of the patient, but they do not completely alleviate the symptoms of HIV, nor do they work for all victims," Weinberger said. "Even w...

New study may show how to forestall a fatal, virus-caused immune-system meltdown

...ntive for drug companies to go out and develop new antiviral compounds for viruses that may or may not ever make it out of places like West Africa.? “This could be of critical importance to the people who live there, and for us if one of these diseases makes it across to here, either naturally like West Nile...

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses

...link in a chain of molecular signals that triggers antiviral responses. "With 30,000-plus proteins in the ce...tifies the protein ?called MAVS, for mitochondrial antiviral signaling protein ?as extremely important for the survival of any virus in the liver." MAVS prote...

New research shows that flu is a trigger of heart attacks

...mong the priority groups to receive the vaccine or antiviral drugs. Meticulous use of plaque-stabilising agents...andemic), "In addition, we are rapidly stockpiling antiviral drugs (such as Tamiflu), so I think we are likely to have the means of preventing or combating the v...

Antivirals effectively curb influenza virus

Two antiviral drugs, oseltamivir and zanamivir, are highly effec...-health consequences. Further studies to determine antiviral efficacy for reducing infectiousness would therefore be of great value," said Halloran, a member of ...

Study uncovers a lethal secret of 1918 influenza virus

...irulence, which we hope will help us develop novel antiviral strategies to both outwit the virus and moderate the host immune response." The same excessive immune reaction is characteristic of the deadly complications of H5N1 avian influenza, the strain of bird flu present in Asia and which has claimed near...

Bird flu -- Call for antiviral drugs to be shared

...l, suggest that international cooperation to share antiviral drugs might be the best way to deal with an emergi...s of a pandemic. Measures might include the use of antiviral drugs and international travel restrictions. In a new study published in PLoS Medicine, researchers ...

New test helps identify hepatitis C patients at high risk of developing cirrhosis

...telligent decision about the urgency of beginning antiviral therapy," he said. "If a patient turns out to be low-risk, we might advise the patient to consider deferring treatment, avoiding unnecessary side effects and expense of current therapy." Last June, Celera licensed Specialty Laboratories of Vale...

Widely used hepatitis B drug spurs HIV drug resistance

... with entecavir leads to cross-resistance to other antiviral drugs used to treat the AIDS virus. "Our results show that entecavir is no different from any other that has been shown to be active against HIV - it breeds resistance rapidly, despite its ability to reduce the amount of HIV in the body," says senio...

Early-stage immune system control of HIV may depend on inherited factors

...t combinations are associated with a more powerful antiviral response, findings that may help develop vaccines ...e progression also contribute more to this initial antiviral immune response," says Marcus Altfeld, MD, PhD, of PARC/MGH, the paper's lead author. An essenti...

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