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Tag: "antisense" at biology news

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

... more stable sense RNA/DNA duplexes than potential antisense RNA/DNA duplexes. "The difference between stability of sense and antisense mRNA/DNA is a property that can aid gene discovery," explains Stoynov. "Thermodynamic stability o...

Researchers discover that sheep need retroviruses for reproduction

...on of the envelope of the enJSRVs using morpholino antisense oligonucleotides, which inhibit translation of specific messenger RNA. When production of the envelope protein was blocked in the early placenta, the growth of the placenta was reduced and a certain cell type, termed giant binucleate cells, did not ...

Scientists discover role for dueling RNAs

...overed that in the case of a gene called IME4, the antisense RNA blocks the sense RNA. In other words, the gene...ase where a specific function in a higher cell for antisense RNA has been found," says Fink, senior author on the paper. "This points to an entirely new process...

Gold nanoparticles could improve antisense cancer drugs

In the fight against cancer, antisense drugs, which prevent genes from producing harmful ... now have demonstrated a new method for developing antisense drugs that outperform conventional antisense agents. The findings will be published May 19 in the jo...

Gene-specific Ebola therapies protect non-human primates from lethal disease

...echnology firm. According to the study's authors, antisense drugs are useful against viral diseases because th...rus." Working with a class of compounds known as antisense phosphorodiamidate morpholino oligomers, or PMOs, the team first performed a series of studies to id...

Ocean virus identified in human blood samples

...oPharma has investigated their proprietary NeuGene antisense as an anti-Vesiviral treatment, and is currently conducting further research and development," said Patrick Iversen, a co-author on the study and senior vice president of research and development at the company. Researchers say that Vesivirus has na...

Mammalian Transcriptome Mapped

...ical research, medicine, and biotechnology because antisense genes are likely to participate in the control of ...e transcriptome project is that there are far more antisense genes than anyone ever knew. Some genes have been known for a long time to have antisense counterpar...

MUHC researchers make cancer target breakthrough

...the growth of tumors." Researchers found that the antisense reduced lung and colon cancer tumors in both labor...tissue cultures and in mice. "Discovering that the antisense works in animal models is a major step forward, and gives us hope that this might also work in human...

Researchers rein in regulatory RNAs

...NA (dsRNA) molecules. A large proportion of these antisense RNAs represent non-coding RNAs. Thus, the researchers expect that these results will lead to a better understanding of roles of non-coding RNAs in gene regulation. ...

Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis

...leotides, including diagnostic probes and primers, antisense including RNAi, microRNA, DNA-based and aptamer drugs and represents a substantial portion of the cost to manufacture these oligonucleotides. NittoPhase?has been rigorously tested at both small and large scales, and has been observed to exhibit supe...

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