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Tag: "antigen" at biology news

Chemical guidance of T cells leads to immunologic memory and long-term immunity

...e cell must encounter its target antigen--but that antigen must be displayed on the surface of another immune... the right dendritic cells presenting the specific antigen they need to see? Moreover, how do they find the particular dendritic cells that have been properly ...

Genomics-based vaccine could prevent deadly cattle disease

...tute (ILRI) of Nairobi, Kenya, cloned 55 candidate antigen genes and screened those genes for response by killer T cells taken from cattle immune to East Coast fever. To complement TIGR's gene selection strategy, ILRI also incorporated a random screen of T. parva DNA for vaccine candidates. In total, the...

Do plants have the potential to vaccinate against HIV?

...he immune system. The team found that the HIV-1p24 antigen produced in this way elicited appropriate immune response in mice. The results have important implications for the economic viability of using plants as bioreactors to produce vaccines against HIV and other diseases. According to Obregon: "Using ant...

Plant-derived vaccines safeguard against deadly plague

...rison study designed to test more than one kind of antigen during the same challenge. "The idea with any re... of the antigen, and guinea pigs vaccinated with V antigen alone had the highest survival rates. "This study provided validation of our plant expression sys...

New test to detect rare proteins in blood

...d assay that uses enzymes linked to an antibody or antigen as a marker for picking out specific proteins. For example, it is used as a diagnostic test to determine exposure to infectious agents, such as HIV, by identifying antibodies present in a blood sample. The sensitivity of detecting molecules by the ...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...fined in this study as a rise in prostate specific antigen (PSA) levels after surgery, she said. Rising PSA after removal of the prostate indicates that the cancer is in the process of recurring. "A methylation test like this could potentially help doctors decide which patients need additional treatment aft...

AIDS-related cognitive impairment exists in two separate forms

...fined in this study as a rise in prostate specific antigen (PSA) levels after surgery, she said. Rising PSA after removal of the prostate indicates that the cancer is in the process of recurring. "A methylation test like this could potentially help doctors decide which patients need additional treatment aft...

Inflammation and drugs to control this activity studied in a variety of tumors sites

... from men who had abnormal serum prostate specific antigen (PSA) levels and/or digital rectal examinations (DRE) suggest that chronic inflammation may be a significant risk factor in the development of prostate cancer. While connections between inflammation and cancer have been shown for some cancers, no on...

Mystery solved: Gold's power against autoimmune diseases defined

...g bacteria and virus on the surface of specialized antigen presentation cells. Presentation of these pieces a...d compounds were shown to render the immune system antigen presenting cells inactive, further strengthening this connection. These findings now give researches...

APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

...d the first days after a T cell encounters the one antigen it will learn to recognize, von Andrian said. Duri...r the presence of anything that might tickle their antigen receptor," von Andrian said. If the T cells don't recognize the antigen, they hop back in the blood...

Mice lacking key immune component still control chronic viral infections

...on strategies that they use to block the classical antigen recognition processes that rely on MHC Class I," Virgin says. Follow-up studies now underway have produced preliminary evidence that these backup plans may be active even when normal MHC Class I is engaged in the fight against chronic infection. Ad...

How HIV 'exhausts' killer T cells

... change the PD-1 level by getting rid of the viral antigen with drugs," said Walker. An antigen is a protein on a virus or other infectious agent that triggers an immune reaction. Walker sai...

A new tool against brain disease

... change the PD-1 level by getting rid of the viral antigen with drugs," said Walker. An antigen is a protein on a virus or other infectious agent that triggers an immune reaction. Walker sai...

Research reveals inner workings of immune system 'thermostat'

... Interferon-γ***but not directly. Another cell, an antigen presenting cell or APC, sends a stimulatory signal back to the T helper 1 cell, ordering it to make Interleukin 10. "What we see is that the 'hot' and 'cool' arms of the immune system aren't independently regulated," Yap said. "They talk to each ot...

T cells activated to fight HIV basis for dendritic cell therapeutic vaccine

... their dying state and with trace amounts of viral antigen still present, these CD4 cells were placed in culture with the beefed up dendritic cells. Recognizing the cells as foreign, the dendritic cells processed the antigen. Importantly, the dendritic cells presenting the HIV fragments were able to stimulat...

H5N1 vaccine could be basis for life-saving stockpile

...ant causing the outbreak, the researchers said. An antigen is a molecule that stimulates production of antibodies by the immune system. A prepublication report on the study appears in the online issue of Journal of Infectious Diseases (JID). The researchers showed that the vaccine completely protected fer...

Scientists to employ Arctic ice and polar bears to protect diversity of world's crops

...ant causing the outbreak, the researchers said. An antigen is a molecule that stimulates production of antibodies by the immune system. A prepublication report on the study appears in the online issue of Journal of Infectious Diseases (JID). The researchers showed that the vaccine completely protected fer...

Immune system police learn early and sometimes badly

...ology that enables a snapshot of the repertoire of antigen receptors that determine what cells recognize, Med...simple matter of numbers: by wearing many hats, or antigen receptors, regulatory T cells can keep their eyes on a lot of different non-regulatory cells. "Th...

Major cancer study aims to identify protein markers for early-stage disease

...n the clinic: Elevated levels of prostate specific antigen (PSA) hint at the presence of prostate cancer, while elevated levels of cancer antigen 125 (CA-125) suggest possible cancer of the ovary or other organs. However, both tests have "false n...

Inflammation markers identify fatigue in breast cancer survivors

... activation of monocytes in the blood, and enables antigen presenting cells to activate T cells as part of the cellular immune response," Dr. Irwin said. The second component of the marker is an index measured by the level of T cells that are characterized by CD69, a cell membrane protein that indicates ear...

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