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Tag: "antigen" at biology news

Association of herpesvirus with lung disorder questioned

...s of tests in the tissue samples, one to detect an antigen associated with HHV-8, the other to detect HHV-8 DNA. Both tests failed to detect either the antigen or the DNA in any of the 22 samples from the two groups with some form of pulmonary hypertension, wh...

Jump-starting T Cells In Skin Cancer

...-tumor T cells in patients vaccinated with a tumor antigen called MAGE-3. In one patient whose tumor regressed after vaccination, the authors found significantly more T cells specific for non-vaccine tumor proteins than were detected before vaccination. Vaccine-specific T cells, on the other hand, became det...

Source of molecular triggers in cutaneous T cell lymphoma identified

...research team considered three broad categories of antigen as the source of the signal: the protein products of tumor viruses, of mutated genes, and of normal but usually inactive genes. The study reports that CTCL develops from a small subset of lymphocytes that are pre-programmed to respond to self-antige...

New binding target for oncogenic viral protein

...A tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important...he transcription, replication and repair of DNA. T antigen also inactivates some of the most important proteins that protect cells against malignant transforma...

Live Recombinant Adenovirus Vaccine Technique Explored

...: High-level production of a papillomavirus capsid antigen from the major late transcriptional unit?include Michael Berg, Julie DiFatta and Egbert Hoiczyk of the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. Author Richard Schle...

Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy

... (ProMuneTM, Coley Pharmaceutical), with a peptide antigen were reported today in the Journal of Clinical Inv... target, in the vaccine, and thus also against the antigen on the cancer cells." The vaccine, combining the CpG 7909 adjuvant and Incomplete Freund's Adjuvant...

PGA on a tour under the skin

...GA to their advantage. PGA is currently used as an antigen for vaccine production against Anthrax This paper presents PGA as a promising target for drug development aimed at combating these hospital-acquired infections and other illnesses caused by related bacteria. ...

Test for early detection of prostate cancer shows promise

...se positive results that plagues prostate-specific antigen (PSA) testing. Study results appear in the May 15, 2005, issue of Cancer Research. The lead author is Robert H. Getzenberg, Ph.D., professor of urology and director of research at the James Buchanan Brady Urological Institute at Johns Hopkins. The ...

Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

... by means of a surface structure called the T-cell antigen receptor complex, or TCR." Two distinct lineages of T cells utilize distinct types of TCR complexes. One lineage employs pairs of TCR proteins termed alpha-beta while the other uses the TCR gamma-delta pair of proteins. The alpha-beta and gamma-delt...

UCLA study assesses cost-effectiveness of Hepatitis B drugs

...deration the two types of hepatitis B -- either e- antigen positive or e-antigen negative -- which require different treatment approaches. Hepatitis B is the most common serious liver infection in the world. The virus attacks liver cells and chronic hepatitis B disease can lead to liver failure, cirrhosis o...

'EuroVacc 02' HIV Vaccine Trial Begins

... "antigen transporters" (vectors). A first dose of antigen A in vector X is administered, followed by a booster using the same antigen A in vector Y this time. In this way, immune reactions to, and the consequent inhibition of the tran...

Natural Killers Could Lead to New Hepatitis Treatments

...gen,?said Littman. “Whenever there is detection of antigen reflecting some kind of damage or local infection, the cell would stop in the vicinity of that signal and provide cytokine signals that would attract other inflammatory cells that destroy the invading microorganism and may also facilitate repair of t...

Newly discovered protein an important tool for sleeping sickness research

... immune system because it is coated with a surface antigen called variant surface glycoprotein (VSG). The hum...r VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies th...

Breakthrough System for Understanding Ocean Plant Life Announced

... immune system because it is coated with a surface antigen called variant surface glycoprotein (VSG). The hum...r VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies th...

UCLA cancer researchers shake loose hidden biomarker

...esearch team places the prostate-specific membrane antigen (PSMA) in a location on the cell that would allow blood-borne immunotherapies to access the biomarker, transforming it from a hidden target into an exposed one. "In prostate cancer cells, PSMA is expressed in the apical region of the cell membrane, ...

Critical step traced in anthrax infection

...ter anthrax therapeutic, shows that the protective antigen component of the bacterial toxin plays an active r...nts leading to cell toxicity and death. Protective antigen (PA) is one of these proteins, and after binding to the cell, seven copies of it assemble into a spe...

First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology

...nities, and an equal ability to be internalized by antigen on prostate cancer cells. At the same time, chicken-produced antibodies lacked the sugar residue, fucose, which greatly increases their cell-killing activity compared to CHO-produced antibodies." To create the antibody-producing chickens, the resear...

A protein in the eye may prevent immune response and protect eyes from disease

...ave been following the immune cells (also known as antigen presenting cells) containing the protein. In previ...foreign substances were presented to the spleen by antigen presenting cells that did not have F4/80. "This led us to believe that the protein F4/80 had a direc...

Scientists turn tobacco against cancer

...monoclonals recognize a particular type of protein antigen on human colorectal cancer cells and have been used in treating metastatic disease and in preventing recurrence in certain high-risk patients. But the technology to produce large amounts of antibody is expensive, and researchers would like to find al...

Nanowires can detect molecular signs of cancer, scientists find

...ertain cancer markers -- such as prostate specific antigen (PSA), PSA-a1-antichymotrypsin, carcinoembryonic antigen and mucin-1. When these telltale proteins come into contact with a receptor, it sparks a momentary c...

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