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Tag: "anticancer" at biology news

New designer lipid-like peptide with lipid nanostructures for drug delivery systems

...biological active materials.” Currently, many anticancer drugs are difficult to deliver to patients due to their difficulty to be soluble in water. “This is a systematic study to combine with lipid molecules,” Shuguang Zhang of MIT, a co-author said, “people have been curious about if these similar molecu...

Research says boiling broccoli ruins its anti-cancer properties

...g habit of boiling vegetables severely damages the anticancer properties of many Brassica vegetables such as broccoli, Brussel sprouts, cauliflower and green cabbage. Past studies have shown that consumption of Brassica vegetables decreases the risk of cancer. This is because of the high concentration in Brass...

Penn researchers show how nanocylinders deliver medicine better than nanospheres

...ped carrier they were able sustain delivery of the anticancer drug paclitaxel to an animal model of lung cancer ...cles composed of synthetic polymers to deliver the anticancer drug paclitaxel to a human lung tumor tissue implanted in mice. The cylinders have diameters as smal...

Discovery could lead to better control of hemorrhagic fever viruses

...nti-TfR1 antibodies have already been developed as anticancer therapeutics (cancer cells are also high in TfR1), and some have already been through clinical trials. Choe's lab will test these antibodies, hoping to find one that inhibits virus entry without compromising TfR1's essential function in cellular iron...

Researchers urge monitoring of bone health during chemotherapy

...ergo more intensive chemotherapy regimens in which anticancer agents are given at more frequent intervals. Studies have suggested these dose-dense therapies could prolong survival in women with breast cancer. "We are not at all advocating ending G-CSF use," says Weilbaecher, an oncologist with the Siteman Ca...

HIV protein enlisted to help kill cancer cells

...laboration began between their labs to exploit the anticancer potential of TAT-Bim. "Unlike most healthy cells...Ph.D. professor of radiology, they are linking the anticancer proteins to tracer molecules that selectively bind to cancer cells. "Dr. Mach designed tracers to ...

Knocking out survival protein could aid leukemia treatment

...bundance of the protein are also more resistant to anticancer drugs such as rituximab, which has revolutionized the treatment of certain chronic and acute leukemias. The study by researchers at the Ohio State University Comprehensive Cancer Center is published online in the journal Clinical Cancer Research....

How T lymphocytes attack

...lls and thus improve the clinical perspectives for anticancer immune therapy. At the Institut Curie, INSERM and CNRS researchers have used two-photon microscopy to demonstrate, for the first time in vivo and real-time, how T lymphocytes infiltrate a solid tumour in order to fight it. These "defenders" methodi...

Chemicals in brown algae may protect against skin cancer

...own that BAPs are strong antioxidants and may have anticancer properties. For this study, Stoner and his collaborators used a strain of hairless mice that are particularly susceptible to UVB-induced skin cancer. Nine experimental groups were used, each with 20 mice. In two groups, BAPs were applied to t...

Bacteria in small sea life yield new way to make potential cancer drugs

...em against predators. Many of these chemicals have anticancer properties, but harvesting them in quantities for large-scale testing and production has been impractical. The new method uses genetic pathways in the bacteria to produce the small chemicals and to manipulate them to invent new potential drugs. T...

A fisheye view of the deadliest breast cancer

...rs make high-resolution 3D images of two potential anticancer compounds at work: a vascular endothelial growth...umor behavior and as a rapid screening system for anticancer drugs. In the race against aggressive breast cancers, Stoletov and colleagues see their xenografted...

Researchers image molecular motor structural changes

...rgo unchecked cellular division, might lead to new anticancer therapies. The team, from Duke University Medical Center, the National Institute of Advanced Industrial Science and Technology in Japan, and the Medical Research Council's Laboratory of Molecular Biology in the United Kingdom, reported its findings ...

Novel EGFR ectodomain mutations in glioblastoma

... often abnormally active in cancer. A new class of anticancer drugs inhibiting the activated EGFR kinase have shown to be effective against such cancers, especially lung cancer. In a new study in PLoS Medicine, researchers have catalogued and characterized the mutations in the EGFR gene that occur in glioblasto...

Activation of microRNA inhibits cancer gene in human cancer cells

...atment with chromatin-remodeling drugs may have an anticancer effect. "Taken together, our results suggest an effect of epigenetic treatment that couples inhibitors of DNA methylation and histone deacetylation to induction of some miRNAs. These miRNAs can potentially regulate expression of target genes that a...

Experimental RNA-based drug kills prostate cancer cells effectively and safely

... attempts to transform silencing RNAs into natural anticancer agents, but such development has been challenging," said Paloma Giangrande, Ph.D., co-leader of the study and an assistant research professor in experimental surgery. Scientists have encountered major obstacles when trying to deliver silencing RNAs...

Buckyballs boost antibody's chemotherapy payload

In the ongoing search for better ways to target anticancer drugs to kill tumors without making people sick, r... that can each be loaded with several molecules of anticancer drugs like Taxol®. In the new research, the scientists found they could load as many as 40 buckybal...

New lab technique churns out fungus' potential cancer fighter

...ight have some tremendous potential as a prototype anticancer agent, but no one has been able to study or develop it because it's so hard to get enough of it from natural sources," says Robert K. Boeckman, professor of chemistry. "You either grow the fungus that makes it, or you go through a complicated chemi...

New lab technique churns out fungus' potential cancer fighter

...ight have some tremendous potential as a prototype anticancer agent, but no one has been able to study or develop it because it's so hard to get enough of it from natural sources," says Robert K. Boeckman, professor of chemistry. "You either grow the fungus that makes it, or you go through a complicated chemi...

New protein target may advance design of HIV and cancer drugs

... cancer. By applying the concept to development of anticancer drugs, the researchers hope to design more specific clinical agents with reduced side effects compared to the very useful, but toxic, cisplatin and congeners. ...

p53, tumor suppression and aging

...lays a critical role in cancer formation, and many anticancer strategies aim to activate p53 in order to curb tumor formation. Mdm2 is a key inhibitor of p53 and therefore an attractive target to modulate p53 activity in cells. However, conflicting evidence exists regarding whether or not p53-mediated tumor sup...

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