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Tag: "antibody" at biology news

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...hool of Medicine in St. Louisinjected mice with an antibody for a key component of brain plaques,the amyloid beta (Abeta) peptide. In areas of the brain whereantibodies cleared plaques, many of the swellings previously observedon nerve cell branches rapidly disappeared. "Theseswellings represent structural d...

Key molecule in plant photo-protection identified

...hool of Medicine in St. Louisinjected mice with an antibody for a key component of brain plaques,the amyloid beta (Abeta) peptide. In areas of the brain whereantibodies cleared plaques, many of the swellings previously observedon nerve cell branches rapidly disappeared. "Theseswellings represent structural d...

Research advances quest for HIV-1 vaccine

...ural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far. The research is publishe...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

... sufferers. On the other end sits a piece of human antibody (called IgG Fcg1) that docks to a cell receptor th...ood cells with either GFD or with a purified human antibody as a control. Then they added the cat protein that triggers allergic reactions to all the blood cell...

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

...ports them to the other side. There itreleases the antibody at the lining of the throat and lungs. If apneumoc...torytract, this germ binds to pIgR and pushes this antibody shuttle backthrough the cell to the bloodstream. Once at the other side of thecell, the pneumococcus...

New comparative toxicogenomics database

...ports them to the other side. There itreleases the antibody at the lining of the throat and lungs. If apneumoc...torytract, this germ binds to pIgR and pushes this antibody shuttle backthrough the cell to the bloodstream. Once at the other side of thecell, the pneumococcus...

Antibodies from plants protect against anthrax

...inated against anthrax. Then genes that encode the antibody itself were inserted into a bacterium that transfe...he gene into the plant cells. "The plant makes the antibody for you in a few days," says Baillie. The antibodies were then purified from leaves harvested from ...

Influenza vaccine uses insect cells to speed development

...ablished safety and the ability to elicit a strong antibody response in humans. "Since all the media used here are chemically stable and commercially available, the process can be easily scaled up for commercial manufacture," says Wang. "New FluBlok vaccines can be developed quickly and safely to address lat...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

...with the Bexxar therapeutic regimen, a radioactive antibody injected into the bloodstream that targets and kil...r a combination of chemotherapy and the monoclonal antibody rituximab. These treatments are usually given every three weeks over a span of up to six months and ...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...lop ways to induce that first line of polyspecific antibody defense during vaccination, if these antibodies are not harmful to those being vaccinated," Haynes said. "We now have a window into how to study HIV vaccines from the host side of the problem," he said. Collaborators on the study include Judith Fle...

HIV vaccine trial breaks ground for future research

...s to the vaccine. The vaccine was able to generate antibody responses in virtually all participants, and, in g...search is needed to be sure whether a high vaccine antibody response is related to a lower incidence of HIV infection. Citing the possible slight vaccine effica...

Promising new West Nile therapy cures disease in mice

... The research team developed an infection-fighting antibody that mimics one produced by people whose immune sy... the West Nile virus. The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile diseas...

Two are better than one

...t's more than three times as effective as a single antibody in inhibiting HER2 signaling. "Understanding how HER receptor degradation works could enhance weak therapeutic efficacy, as well as provide ways to sensitize patients to overcome inherent or acquired resistance to cancer treatment," says Yarden. Pr...

NIAID begins clinical trial of West Nile virus vaccine

...he DNA vaccine's exploitation of both cellular and antibody immunity offers a potentially potent defense against West Nile virus," says Barney Graham, M.D., Ph.D., chief of the VRC's Clinical Trials Core Laboratory. Adds Dr. Graham, "In our experience in clinical trials, DNA vaccines generally cause few side ...

Wake Forest scientists find new combination vaccine effective against plague

... protein termed flagellin is added to the vaccine, antibody levels against the plague bacteria are 500,000 times higher. "Flagellin can function as an effective adjuvant, making a vaccine that protects against the most dangerous form of the plague ?pneumonic plague," reported Mizel, professor and chairman of...

Ebola virus: from wildlife to dogs

...breaks. From 9 % in the two large cities of Gabon, antibody prevalence goes up to 25 % in the untouched villages of the epidemic area, reaching 32 % in the villages where human cases have been attributed to an infected-animal source. These domestic animals could therefore become infected and excrete virus ove...

Active Vaccine Prevents Mice From Developing Prion Disease

...mmune response to the gut and mainly stimulates an antibody response, says Dr. Wisniewski. "By giving our vaccine orally, we're stimulating an immune response mainly in the digestive tract," he explains. "Thus, harmful prions in contaminated food will be destroyed in the gut and will not reach other organs in...

New vaccine means bye-bye to bacteria in the lung

...or. Immunization of mice with this vaccine induced antibody production and protected the mice from exposure to a deadly dose of the bacteria. Importantly, the mice could be repeatedly given the vaccine and the immune response against P. aeruginosa was boosted. Usually, adenovirus vectors do not allow for repe...

First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology

...hicken embryonic stem cells the genes encoding the antibody and the regulatory sequences restricting its depos...ike other transgenic animal systems, the time from antibody identification to production in eggs can be as short as 8 months versus 18 months to 3 years for goa...

Scientists turn tobacco against cancer

...ferson Medical College, inserted DNA coding for an antibody against colorectal cancer into tobacco plants. The...ts. But the technology to produce large amounts of antibody is expensive, and researchers would like to find alternatives. Dr. Koprowski, Dr. Ko and their co-wo...

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