Different microarray systems more alike than previously thought
...called two-color spotted cDNA arrays, and two used another commercial platform called two-color long oligonucleotide arrays. In general, the study showed Affymetrix GeneChips generated more reproducible data than the other microarrays. But the researchers also showed that any of the platforms can be quite g...New understanding of DNA repair may pave way to cancer treatments
... protein known for its role in gene regulation has another important function, that of initiating DNA repair. The study, published in the May 27th edition of Molecular Cell, points to new targets for treatment of cancer. Ze'ev Ronai, Ph.D., Director of the Institute's Signal Transduction Program, and his co...Live vaccines more effective against horse herpes virus
...tudy compared the effectiveness of MLV vaccines to another more widely used vaccine for equine herpes. Owners and veterinarians have been wary of live vaccines because of past incidences in which a previous MLV that was incompletely weakened caused neurological disease symptoms after it was administered. The...Study: 'homemade' gene expression technology unreliable
...producible data. One of these is used by CROET and another by OHSU's West Campus microarray resource facility. "It's possible to buy a robot which will take some copies of RNA on a small pin and then write that on a glass slide repetitively until one can build up hundreds of thousands of different spots on ...A puzzle piece found in unraveling the wiring of the brain
...rganelles that transport proteins from one site to another in the cell. Neurons in the fly brain that lack sec15 not only display aberrant wiring patterns, but also show misplacement of proteins required for correct nerve cell contact choices. Most of these cell contact proteins were previously known to di...Brain-injury rehabilitation depends on acetylcholine circuitry
...particular circuitry of neurons that "talk" to one another using the brain chemical acetylcholine, researchers led by James Conner and Mark Tuszynski in the Neural repair Group at UCSD have discovered. Their finding in rats could help enhance rehabilitation to recover from such injuries by leading to the dev...Scientists journey to southern Africa to unravel the secret world of elephant communication
...he dense forest canopy." Human-generated noise is another concern for conservationists. Researchers have found that rotating helicopter blades generate low-pitched noises, and possibly seismic vibrations, that can disrupt and frighten wild herds located far away. David Larom and others argue, therefore, tha...New tumor-suppressor gene discovered
... which also has discovered how the gene works with another tumor suppressor to control tissue growth. The tea...ad, eye, wing, leg, and antenna. He also generated another mutant form of the mats gene--this time with a huge missing pie ce of genetic material caused by ano...Grasping metaphors: UC San Diego research ties brain area to figures of speech
...f translating one sort of sensory information into another ?patients with damage to the angular gyrus performed at the level of chance. Three age-matched control subjects, on the other hand, with lesions in other areas of the brain, performed normally both with proverbs and the booba/kiki test. Disproporti...Turning viruses into allies against cancer
...irotherapy vector. "We expect this work will take another two years before this technology will be available for testing in patient studies," said Blechacz. ...Researchers discover underwater volcano
... submarine volcano growing in the summit crater of another larger underwater volcano, Vailulu'u. Researchers explored the unique biological community surrounding the eruption site, and were amazed to find an "Eel City," a community of hundreds of slithering eels. This new volcano, dubbed Nafanua after the f...Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
...s up with a transferrin receptor on the surface of another cell. The transferrin binds tightly to a receptor on the cell's surface, where it is drawn inside and surrounded by a small vesicle. The vessels are acidified, causing the nanoparticles to release its contents ?the siRNA. "Since transferrin receptor...At long last, scientists figure out how plants grow
...called SCF(TIR1). SCF(TIR1) and auxin binds to yet another protein that represses the expression of a particular set of genes. And it's this complex of auxin, SCF(TIR1) and the repressor that signals enzymes to destroy the repressor, thereby turning on the repressed gene. "The key interaction is between TIR...Habitat use by North Pacific right whales, Eubalaena japonica, in the Bering Sea and Gulf of Alaska
...t, the results of this study refute conclusions in another study that a "habitat shift" occurred when right whales moved from deep continental slope waters in the SEBS during the 1940s to 1960s to now occupy "a different habitat" on the middle-shelf of the SEBS. Given that right whales have been seen in midd...Biochemists report discovery of structure of major piece of telomerase; implications for cancer
...NA, and how proteins and DNA and RNA recognize one another to switch genes on and off in cells. Her laboratory has worked on telomeres and telomerase for more than a decade. A member of UCLA's faculty since 1985, Feigon was the first UCLA scientist to use NMR to determine DNA and RNA structures. ...Scientists discover that three overlapping signals in embryo help get the backbone right
...es where the belly would normally form - to induce another head, brain and spinal cord. The tissue they trans...ing noggin instead of implanting an organizer from another embryo. They also discovered xnr3, and other researchers isolated three more factors - chordin, foll...One gene links newborn neurons with those that die in diseases such as Alzheimer's
...part. The replaceable neurons send projections to another part of the brain a few millimeters away from the ...re new neurons thus have a chance of surviving. In another experiment the scientists allowed male finches to sing to a female before analyzing the birds' brain...Friendly bacteria in humans may protect against HIV
...ity of different strains to bind to baker's yeast, another microorganism coated with mannose-rich sugars. They found a small group of lactobacilli that bound to mannose and further testing against HIV revealed two strains that specifically trapped the virus and blocked infection. Due to high rates of mutati...NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
...ier studies also showed that mice that lacked p27, another tumor suppressor gene, had a higher risk of developing tumors in both the small and large intestine. Now, however, they have linked that risk to a high-risk diet. In the first part of the study, they found that mice lacking a p27 gene that were fed ......k in response to the shifted light schedule, while another part of the clock, represented by a ventral (lower) group of cells, exhibited a distinct pattern of activity that corresponded to fast resetting of the clock. Perhaps contributing to the different behavior of the two groups of clock cells are the ef...