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Tag: "animal" at biology news

LIAI completes world's most comprehensive analysis on influenza virus data

...wed that most of the detailed studies were done in animal models, primarily mice, with very little data coming from studies with humans or birds. Only one of the antibody epitopes came from a human. "This is understandable given the ethical and health issues of testing a potential pathogen in humans," Wils...

Tracking sperm whales and jumbo squid

...d a whale, the scientists carefully approached the animal and attached an electronic depth recorder to its back. Later, whenever the tagged whale surfaced for a breath of air, the device would transmit recorded data about the animal’s movements to an orbiting satellite. Jumbo squid also were abundant, wi...

Bacterial walls come tumbling down

...oenomycin. Moenomycin has been used for decades in animal feed to promote livestock growth. Bacteria have sh...anding of how the enzyme works and how a very good animal antibiotic inhibits the enzyme." Although moenomycin is poorly absorbed by the human body, the new u...

NIAID DNA vaccine for H5N1 avian influenza enters human trial

...roach to be effective against influenza viruses in animal models, including highly pathogenic viruses such as the H5N1 strain and the H1N1 virus that caused the deadly 1918 pandemic. The DNA vaccine used in this study is similar to other investigational vaccines evaluated by the VRC that hold promise for co...

Hybrid molecule causes cancer cells to self-destruct

...ng for new drug-delivery methods and preparing for animal testing. The researchers believe the hybrid molecule will have minimal effect on healthy cells. Through the Johns Hopkins Technology Transfer Office, they have filed an application for a U.S. patent covering this class of compounds. ...

Fighting influenza & co. with 40,000 blood samples

...rsity Clinic in Dijon is designing a corresponding animal model. The Belgian project partner RNA-Tec wants to test new approaches on the animals in order to coax maximum performance from the immune system of older animals. If the immune system begins to flag with age, this could also be due to a long-for...

Soft-cell approach cuts animal tests

...irror well-established lethal values obtained from animal studies - a long-established method in toxicologic...ts for work that has reduced the use of animals or animal products in laboratory-based research, education and testing. Many industrial and environmental ...

3 proteins may play important role in nerve-cell repair

...ther the approach can be translated in preclinical animal models of stroke or spinal cord injury." ...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...manner compatible with clinical use (i.e., without animal feeder layers) and even without the need for immunosuppression. These were a few of a number of conclusions arrived at by an international collaboration led by Evan Y. Snyder, M.D., Ph.D., and spearheaded by a member of his lab, Jean-Pyo Lee, Ph.D., ...

Chlamydia vaccine a step closer to reality

.... "We've been testing these proteins as part of animal trials...and we think we've got the answer. It is ...t within three to five years we'll be finished the animal trials and be looking at clinical trials in humans." Professor Timms said Sanofi-Pasteur's fundin...

Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex

... protein defies a longstanding assumption. When an animal dies, protein immediately begins to degrade and, in the case of fossils, is slowly replaced by mineral. This substitution process was thought to be complete by one million years. "For centuries it was believed that the process of fossilization des...

Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps

...ncy virus (SIV), is widely recognized as the best animal model for human immunodeficiency virus (HIV) infection. The rhesus genome sequence will also serve to enhance essential research in neuroscience, behavioral biology, reproductive physiology, endocrinology and cardiovascular studies. In addition, the ...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...fest a more aggressive behavior. "With accurate animal models of both forms of pancreatic ductal cancers now in hand, it should be possible to unravel the detailed mechanisms behind their distinct behavior and hopefully identify points of vulnerability in the more fatal form to improve survival," Hingora...

In-shell vaccine for chick disease

...ve of BBSRC, said: "BBSRC research into endemic UK animal disease has the potential to save UK farmers and c...ions of pounds each year. IBV is one of the severe animal diseases that BBSRC supports research into, and the work at the Institute for Animal Health shows re...

New protein inhibitor impedes growth of cancerous cells

...of cancerous cells, both in cell culture and in an animal model for human tumor growth. BI 2536 caused growth arrest and cell death in cell lines derived from a variety of human cancers, and it inhibited the growth of human tumor grafts in mice, resulting in the death of tumor cells and regression of large ...

New mechanism for nutrient uptake discovered

...s," noted co-author Wolf Frommer. "Imagine a large animal marking its territory. A sudden flow of ammonia could be toxic to the plant. If it weren't for a rapid-fire shutdown plants could die. The conservation of this feature in the related transporters in bacteria, fungi, plants, and animals suggests that ...

Microbes start immune response by sneaking inside cells

...earchers elsewhere ?now taking place in laboratory animal studies ?offers a different way of thinking about how best to design future human vaccines, as well as drugs that could more precisely target the body’s inflammatory response in rheumatoid arthritis and some other autoimmune diseases. “In our stud...

Mechanisms involved with tumor relapse identified

...00, Manjili and his colleagues have been employing animal models of breast cancer to evaluate anti-tumor efficacy of a vaccine formulation they created. This vaccine formulation combines a heat shock protein 110 (HSP110), as an adjuvant, with a tumor antigen HER-2/neu, as a protein target expressed in breas...

Scientists find method to pick noncompetitive animals, improve production

...e new method is a tool that may contribute both to animal well-being and to securing the world's future food...n the future between individuals and among various animal species. "This is important because the most stable ecosystems are those that have multiple speci...

University of Alberta researchers unravel intricate animal patterns

...al model to describe the formation and movement of animal groups. The work is published in the prestigious journal, "Proceedings of the National Academy of Sciences." "Every individual in the group is influenced by movement of the individuals in its neighbourhood," said de Vries. Conversely, the individu...

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