First clinical trial of gene therapy for childhood blindness
...ed Genetics, Seattle, USA. Previous work using animal models has demonstrated that this gene therapy can improve and preserve vision. During trials, the vision of dogs with the defect was restored to the extent that they were able to walk through a maze without difficulty; something they could not do be...Corals -- More complex than you?
... times, may thus be a living ‘museum?of ancestral animal genes. However corals use all those genes to produce only 12-14 types of body cells. Humans, on the other hand, have developed hundreds, even thousands of different cell types. A possible explanation for this, Prof. Miller believes, is that co...Molecule that destroys bone also protects it, new research shows
...chers had shown previously, using rats and mice as animal models, that blocking the receptor for IL-17 could be an effective therapy for RA and possibly for other autoimmune diseases such as multiple sclerosis, colitis, psoriasis and lupus. The effects of an IL-17 deficiency in periodontal disease, howe...LIAI scientists make important finding on cytomegalovirus transmission
..." Ware and Croft’s next step will be conducting animal studies with the IL-10 suppression and the OX40 enhancement combined into one treatment. "We tested them separately, but they may well be even more effective when combined," Croft said....Researchers publish first marsupial genome sequence
...as a model. For example, it is the only laboratory animal known in which ultraviolet radiation alone can cause melanoma, a type of skin cancer that also strikes humans exposed to too much of the sun's ultraviolet rays. Having the sequence of the opossum genome will give researchers the ability to learn more...Dealing deadly cancers a knockout punch
...i-cancer activity against cultured tumor cells, in animal models, and in human clinical trials. Oncolytics' ...olysin plus the cancer drug cyclophosphamide in an animal model of melanoma. When treated with both agents, test animals experienced enhanced tumor regression...Scientists develope a new model of artificial canine skin
...tat Autònoma de Barcelona, in cooperation with the animal nutrition company Affinity Petcare, have developed an artificial cellular model which faithfully reproduces the characteristics of dog’s skin and which will allow, therefore, the carrying out of various lines of research related to skin biology and p...Researchers attach genes to minichromosomes in maize
... kernels (called an endosperm) can be used to grow animal proteins and human antibodies that treat diseases and disease symptoms. Minichromosomes could enable new and better production of these foreign proteins and antibodies. In addition, scientists also may be able to use them to develop plants better sui...DNA-damage test could aid drug development
... that may prove dramatically cheaper than existing animal tests. This assay would allow genetic toxicity to ... process." It also could help to avoid issues with animal testing. "The European Union is trying to minimize animal testing," Shuga points out. "A ban on anim...Sleepless for science: Flies show link between sleep, immune system in Stanford study
... "We want to know how the internal clock knows the animal is infected, and how does the immune system know that you are not sleeping properly"" said Schneider. "How do those messages get sent back and forth"" Their findings also raise the question of why the flies have a change in their sleep pattern whe...Dinosaur hearing, listening to muscle noise, quieter cubicles
...earing of dinosaurs compare to that of present-day animal species" What are some ways to improve acoustical conditions in office cubicles" How can sound waves diagnose and monitor muscle activity" These and other questions will be addressed at the 153rd Meeting of the Acoustical Society of America (ASA) ...From the deep -- Researchers find new species of sea anemone
...It's customary to name a newly discovered plant or animal species after the person who found it, or after the place where it was discovered. Collecting deep-sea creatures is a tedious process that involves a lot of high-tech equipment like underwater video cameras attached to remotely operated vehicles (...Herpes infection may be symbiotic, help beat back some bacteria
... fundamental level. This could mean the virus-free animal models scientists use to study vaccines, autoimmun...o think about that as we consider the implications animal model results hold for human diseases." Scientists have recognized for years that many types of b...The quest for an effective HIV vaccine presents new possibilities, challenges
...IV vaccine by spurring cellular immunity. Numerous animal and human studies have confirmed how important cellular immunity is in the early and later stages of HIV infection, even though the virus is never completely eliminated. Vaccines that induce strong cellular immune responses may have some benefits, sa...Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys
...c cells in the treatment of Parkinson's disease in animal experiments and in humans. The advantage of this c...n with fragments from the carotid body of the same animal This region of the brain where the fragments from the carotid body are implanted is the area where d...Iowa State scientists demonstrate first use of nanotechnology to enter plant cells
...ivated to pop open and release the cargo inside of animal cells. This unique feature provides total control ...they don’t have walls. The nanoparticles can enter animal cells through a process called endocytosis ?the cell swallows or engulfs a molecule that is outside ...Latent memory of cells comes to life
...hanges are at the origin of the immense and varied animal and plant life on earth. Constructive changes in the DNA, that is, changes creating new functions, normally arise by a slow and gradual process that involves natural selection operating over many generations. Sometimes however, dramatic and very ...Rare soft-shell turtle, nesting ground found in Cambodia
... crush bone. “It has the fastest strike of any animal I’ve ever seen, including cobras,?Emmett said. The researchers also found a nesting ground for the species and brought back eggs that have since hatched. The hatchlings were released into the wild on May 8, together with another adult turtle and a...Left-right wiring determined by neural communication in the embryonic worm
..., like handedness, AWC asymmetry arises before the animal is fully developed, maybe they needed to examine the nervous system of the embryonic worm. Using an electron microscope, they discovered that the developing worm's neural network, which had not previously been mapped, was completely different from th......emonstrates how a fused nasal bone helped turn the animal into a "zoological superweapon." "Fused, arch-like nasal bones are a unique feature of tyrannosaurids," said Dr. Eric Snively, a post doctoral research fellow at the University of Alberta. "This adaptation, for instance, was keeping the T. rexes fr...