Virologist finds contagious equine flu in dogs
...t -- called a PCR (polymerase chain reaction) that amplifies and detects small amounts of DNA or RNA in a blood or tissue sample -- ruled out avian flu strains H5 and H7. The isolate was then sent to the CDC where Ruben Donis, Cornell Ph.D. '87, one of Dubovi's former graduate students and currently chief of...NHGRI expands effort to revolutionize sequencing technologies
...A sequencing by denaturation. The resulting system amplifies DNA directly on a microchip, enabling the process of sequencing to be done on a single miniaturized device. Jingyue Ju, Ph.D., Columbia University, New York. $970,000 (3 years) "Modulating Nucleotide Size in DNA for Detection by Nanopore" This grou...Mayo Clinic collaboration discovers protein amplifies DNA injury signals
...collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin. Once amplified, even low-level damage signals become strong enough to activate the cell's natural repair processes while the injury is most tractable to repair. How this "distress call" was commu......his reorganization, the bacterium's receptor array amplifies the signal that a specific molecule has been sensed outside the cell. This structural shift then activates kinases, or enzymes, within the cell, starting a chain reaction that leads to a response, such as changing how the flagella (or tails) spin. Th...