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Tag: "amplification" at biology news

Novel technology detects human DNA mutations

...the need for costly, time and labor intensive gene amplification or enzymatic interventions ?two widespread methods currently used to perform such analyses. "Nanosphere's new SNP analysis methodology for whole genomic human DNA is a powerful example of the versatility of our proprietary ClearReadTM nanoparticle ...

Breakthrough Microarray-based Technology for the Study of Cancer

...nges across the entire genome. The Platformenables amplification or non-amplification of total genomic DNA instudies of the whole genome, providing better ease of use and improvedexperimental design....

Researchers reveal the infectious impact of salmon farms on wild salmon

...otland, Norway, and Ireland; in each area parasite amplification on fish farms seems to increase disease levels in the local fish community. However previous studies have not shown nor quantified the direct transmission. This study captures the chain of events." "Part of the contentious debate about sea lice is t...

Researchers develop rapid diagnostic tool for pathogen identification

...hod known as polymerase chain reaction that allows amplification of genetic sequences and on a technology previously used for DNA sequencing and detection of genetic polymorphisms. Genetic probes for pathogens were coupled to markers known as mass codes. After amplification, incorporated mass codes were detected b...

Nanoscale Diagnostic Sets Sights on Alzheimer's

Using their novel bio-bar-code amplification (BCA) technology, researchers analyzing fluid from around the brain and spinal cord have detected a protein linked in recent studies to Alzheimer's disease. Interesting application Read more about the bio-bar-code technology : - Gold nanoparticle...

Discovery could be key to bioterrorism defense

...nerable to these viruses, making the potential for amplification in intermediate hosts and transmission greater. Ephrin-B2 is highly conserved in animals, and this finding sheds light on how these viruses can infest such a wide range of hosts. "In addition to our concern about Nipah and Hendra viruses as emerging...

Scientists track stealth DNA elements in primate evolution

...progeny elements may act as 'master' genes for the amplification of Alu subfamilies and are responsible for producing the majority of the subfamily members. Due to their high retrotransposition levels, however, they are likely to be rapidly purged from human populations through natural selection." Dr. Batzer, pri...

New technique rapidly detects illness-causing bacteria

...ors rely on a time-consuming technique called gene amplification that requires costly equipment: Technicians take a...cess takes only 35 minutes, while traditional gene amplification techniques may take many hours. Promising early results suggest the sensitive method could detect f...

New study shows SARS can infect brain tissue

...ully and on an individual basis, as they may allow amplification of the SARS coronavirus in the brain. "Superinfection" with other pathogens could also contribute to SARS' harmful effects on the brain. "Physicians should pay more attention to the prevention of brain damage if [SARS patients] are superinfected with...

NHGRI expands effort to revolutionize sequencing technologies

...ive technologies: massively parallel, whole-genome amplification and DNA sequencing by denaturation. The resulting system amplifies DNA directly on a microchip, enabling the process of sequencing to be done on a single miniaturized device. Jingyue Ju, Ph.D., Columbia University, New York. $970,000 (3 years) "Modu...

UCLA discovery will aid in treatment of patients with a deadly brain cancer

... target EGFR, blocking the cell signals that drive amplification of the protein and speed cancer growth. A subset of glioblastoma patients responded to Tarceva and Iressa, but it was not clear what characteristics made them respond to these drugs. There had to be critical molecular factors that determined response...

Typhoid fever led to the fall of Athens

...t microbial DNA. Aided by modern DNA recovery and amplification techniques, Papagigorakis et al used dental pulp to identify DNA sequences similar to those of the modern day Salmonella enterica serovar Typhi, the organism that causes typhoid fever. The results of this study point to typhoid fever as the probable...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

...ll detect low-dose damage signals? We believe this amplification process involving MDC1 is the answer to that question, and that it is critical because it's involved in even very subtle injury, such as a single DNA strand break -- which is very small. It is a very sensitive communication pathway." Method To in...

Earth Rx: A microbial biotechnology prescription for global environmental health

...with the advent of polymerase chain reaction (PCR) amplification of microbial DNA and a new view of the evolution of organisms based on their ribosomal RNA. These technologies have advanced into high-throughput genomic and proteomic protocols that can detect specific genes and their metabolic functions with great...

New test to detect rare proteins in blood

...e." The FACTT technology uses a different enzyme amplification system so quantitative signals can be obtained from even a few protein molecules compared to ELISA. "The technology is remarkably adaptable to any protein and can be performed in an automated format," notes Greene. He states that the technology will ...

Yale researchers find environmental toxins disruptive to hearing in mammals

... Sensitive hearing in mammals relies on cochlear amplification resulting from the motor activity of outer hair ce...er hair cells and caused profound changes in sound amplification in the inner ear. In his previous study using TBT on isolated cells only, Santos-Sacchi had propose...

Genome changes tracked during multiple myeloma initiation, progression and treatment

...overed oncogenes and tumor suppressor genes. These amplification and deletion patterns define new disease subgroups of MM that are characterized by varied dysregulation of distinct cancer-relevant genes and can be correlated with different clinical outcomes. Importantly, several candidate genes identified in this ...

Scientists uncover rules for gene amplification

Gene amplification plays an important role in causing cancers via act...d of the chromosome will determine the fate of the amplification event Gene amplification is the increase in copy number of a particular piece of DNA and is a hall...

Speeding discovery of the 'human cancer genome'

... Such chromosomal rearrangements often lead to the amplification of cancer-causing genes or the loss of genes that normally suppress tumor formation. But as genome technology continues to improve, providing ever-increasing resolution, researchers have found more than they had expected, Chin said. In human me...

UGA study explains peaks and troughs of dengue epidemics

...ngue epidemics. The conventional wisdom is that an amplification of the severity of disease caused by repeat infections with different strains, a phenomenon known as antibody-dependent enhancement, drives the boom and bust cycles of dengue epidemics. "Temporary cross-immunity has been ignored by the epidemiologi...

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