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Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

..., the risk of breast cancer was three times higher among women with the poorest DNA repair capacity compared with those with the highest. "[T]hese data support the hypothesis that deficient DNA repair capacity is associated with susceptibility to breast cancer and may be a valuable in vitro biomarker to i...

UCSB scientists probe sea floor venting to gain understanding of early life on Earth

...nd an abundance of microbes in the subseafloor are among the most remarkable scientific findings in Earth science during the latter half of the twentieth century, and have now become a powerful motivation for research and exploration, according to the National Science Foundation, a major funder of this wor...

Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants

...nal Nanotechnology has an international readership among academic,government and corporate sectors, and is dedicated to coverage of allaspects of nanoscale science and technology from a multidisciplinaryperspective.Ozkan and his colleagues utilized cadmium selenide (CdSe) quantum dotscoated with zinc sulph...

W.M. Keck Foundation funds study of friendly microbes

...ns in the composition of gut microbial communities among different people may be an important factor that influences predisposition to obesity and obesity-related disorders such as diabetes and heart disease. Unfortunately, comprehensive analysis of the composition and functions of these microbial communi...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

...randomized, double blind, placebo-controlled study among 20 HIV-infected women to assess the antiviral activity of PRO 2000 in cervicovaginal lavage (CVL) fluid collected before and one hour after administration of a single intravaginal dose of PRO 2000 gel or a matched placebo gel. CVL specimens were test...

Anti-bacterial additive widespread in U.S. waterways

...ereby making it the fifth most frequentcontaminant among 96 pharmaceuticals, personal care products andorganic wastewater contaminants evaluated.To determine the validity of the analysis, the researchers comparedtheir predicted nationwide levels of contamination to experimentallymeasured concentrations in ...

The secret to longevity in tubeworms

... the deep sea tube worm, Lamellibrachia luymesi is among the longest-lived of all animals, but how it obtains sufficient nutrient ?in the form of sulfide - to keep going for this long has been a mystery. In a paper just published in the premier open-access online journal PLoS Biology, Erik Cordes and colle...

Male circumcision reduces risk of HIV transmission from women to men

...bility ofHIV infection per act of heterosexual sex among a population withmultiple sexual partners has found that uncircumcised men have morethan twice the risk of acquiring HIV than do circumcised men.In the study, published in the Feb. 15 issue of The Journal ofInfectious Diseases, now available online, ...

Another Look Finds Promising Proteomics Test is Not Biologically Plausible

... only misdiagnosed three healthy individuals. But among others who subsequently tested the study’s data for reproducibility were Baggerly and his colleagues (Kevin Coombes, Ph.D., and Jeffrey Morris, Ph.D., from M. D. Anderson Cancer Center, and Sarah Edmonson, M.D., from Baylor College of Medicine). They...

New species from old data

... only misdiagnosed three healthy individuals. But among others who subsequently tested the study’s data for reproducibility were Baggerly and his colleagues (Kevin Coombes, Ph.D., and Jeffrey Morris, Ph.D., from M. D. Anderson Cancer Center, and Sarah Edmonson, M.D., from Baylor College of Medicine). They...

Cracking the olfactory code in bees

... only misdiagnosed three healthy individuals. But among others who subsequently tested the study’s data for reproducibility were Baggerly and his colleagues (Kevin Coombes, Ph.D., and Jeffrey Morris, Ph.D., from M. D. Anderson Cancer Center, and Sarah Edmonson, M.D., from Baylor College of Medicine). They...

Signaling protein builds bigger, better bones in mice

... only misdiagnosed three healthy individuals. But among others who subsequently tested the study’s data for reproducibility were Baggerly and his colleagues (Kevin Coombes, Ph.D., and Jeffrey Morris, Ph.D., from M. D. Anderson Cancer Center, and Sarah Edmonson, M.D., from Baylor College of Medicine). They...

Scientists detect probable genetic cause of some Parkinson's disease cases

...ory of the disease and it is relativelycommon even among those without a family history, it's possible thatdetecting this mutation will help identify people at increased risk forParkinson's disease."About 50,000 Americans are diagnosed with Parkinson's disease eachyear. The disease occurs when certain nerv...

A much-needed shot in the arm for HIV vaccine development

...quantitative laboratorytools that make comparisons among vaccine studies feasible." What isneeded, they argue, is a way of tying all of these opportunitiestogether, and their plan provides a model for doing just that."A preventive vaccine is the world's best long-term hope for bringingthe HIV/AIDS epidemic...

Ancient olfaction protein is shared by many bugs, offering new pest control target

...utionary conservation of the Or83b coding sequence among the fruit fly, the medfly (a citrus pest), the corn earworm moth (which damages corn and tobacco), and Anopheles gambiae, the malaria mosquito. When the medfly, moth, and mosquito versions (or "orthologues") of Or83b were expressed in fruit flies tha...

Whole genome fine map of rice completed

...ay a solid foundation for studying the differences among strains of rice and shed insight into mechanisms o...w materials for gene genesis, creating differences among the grass family. The Chinese Superhybrid Rice Genome Project, initiated by BGI in 2000, focused on...

U-M scientist to talk about tissue engineering at AAAS

...laboration includes dentists, M.D.s and engineers, among others. They all bring a different perspective, and it leads to scientific advances that couldn't happen in any one discipline, Krebsbach said. "That's the beauty of tissue engineering. It has to be multi-disciplinary to work," he said. ...

Genome-wide mouse study yields link to human leukemia

... Sequencing (RLGS) to compare methylation patterns among the three groups of mice ?a method of using enzymes and gel electrophoresis to map tiny bits of DNA on a grid. The stretches of DNA, referred to as fragments, show up as smudgy blobs on a test film. If a fragment is dark and definite, it is not methy...

Breakthrough Microarray-based Technology for the Study of Cancer

...cite a huge body of experimentationand publication among the cancer research community."In the past, comparative genomic hybridization was performed throughthe optical imaging of whole chromosomes, a technique with limitedsensitivity, resolution, quantification and throughput. Efforts inrecent years to use...

Improved Outcomes Releases GeneLinker(TM) Gold and Platinum Version 4.6

...ng theeffect of bad samples by requiring consensus among multiple learners tomake predictions." said Mark Chatterley, VP Bioinformatics at IOS."Despite our new focus, we are still enhancing our products for geneexpression data analysis. We've added additional data import scripts tohandle Koadarray ratio an...

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