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Tag: "amino" at biology news

Unraveling the mysteries of poison

...hus only effective when it recognises a particular amino acid sequence in the ion channel. It is also important how intrinsically flexible the binding partner is; for a strong interaction to take place, the molecules of both partners have to be able to change their structures. Applying these new spectrosc...

Novel method reveals how menthol discovery could point towards new or improved pain therapies

...t's a well established method to mutate individual amino acid residues in an ion channel protein and examin...lly, the new methodology could be used to identify amino acid residues in certain ion channel proteins and G-protein coupled receptors (proteins involved in ...

Computer simulation hints at new HIV drug target

...mation -- the three-dimensional arrangement of the amino acids that make up a protein -- is the first step ...utant protease enzyme with two mutations in the 99 amino acids that make up each half of the enzyme. One of those mutations, V82F, is common, and it can emer...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...mation -- the three-dimensional arrangement of the amino acids that make up a protein -- is the first step ...utant protease enzyme with two mutations in the 99 amino acids that make up each half of the enzyme. One of those mutations, V82F, is common, and it can emer...

Creation of antibiotic in test tube holds promise for better antibiotics

...t Urbana-Champaign. Nisin, a peptide, contains 34 amino acid residues and the unusual amino acids lanthionine, methyllanthionine, dehydroalanine and dehydro-amino-butyric acid. The latter are ...

Scientists force viruses to evolve as better delivery vehicles for gene therapy

...ed from those of the original strain by only seven amino acid building blocks, two of which were responsibl...cratch, just trying to rationally decide which two amino acid changes to make on the virus, there is no way you would have guessed those two," Schaffer said....

Jefferson researchers building a better rabies vaccine

...ation in a rabies virus gene that changes a single amino acid in the virus's outer coat. The alteration was enough to turn a "safe" virus into a deadly version, making the virus unusable for vaccination. Wildlife rabies is a substantial health problem in the United States. It is particularly prevalent alo...

Groovy protein essential for promoting cancer development

..., and when the researchers made a series of single amino acids changes within the domain, they found that three of these severely affected the binding of the chromosome end. "They turned out to be lined up right within that groove," Cech said. The scientists found that these same mutations abolished telo...

Report lists top 20 most-vulnerable African carnivores

..., and when the researchers made a series of single amino acids changes within the domain, they found that three of these severely affected the binding of the chromosome end. "They turned out to be lined up right within that groove," Cech said. The scientists found that these same mutations abolished telo...

Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease

...protein. MSUD is a metabolic disease which causes amino acids from proteins to accumulate in the body. The...the sweet smell of the urine. The accumulation of amino acids in the blood can cause metabolic crisis at any age, which can lead to brain swelling, stroke a...

Protein receptor cools passion of 'kiss and run' nerve cells

...ery that causes release of neurotransmitter -- the amino acid glutamate. "It's very fast," said Alford. "You turn on a G protein, and it immediately targets the mechanism to modify release." On the receiving cell, the post-synaptic side, there is a range of protein receptors that vary in sensitivity to t...

Manchester scientists create new bio-gel for 3D cell culture

...ial made from combinations of dipeptides (pairs of amino acids) to provide an environment in which cells can be cultured under physiological conditions. Uniquely, the gel mimics the properties of cell scaffolds which naturally occur in the body and has potential applications for wound healing and tissue e...

Use of amino acid supplement following a heart attack provides no benefit, may be harmful

Use of the amino acid supplement L-arginine following a heart attack does not improve certain cardiac functions and measurements and may be associated with an increased risk of death, according to a study in the January 4 issue of JAMA. L-arginine is a widely availa...

Little known DNA repair enzyme may be a tumor suppressor gene

Use of the amino acid supplement L-arginine following a heart attack does not improve certain cardiac functions and measurements and may be associated with an increased risk of death, according to a study in the January 4 issue of JAMA. L-arginine is a widely availa...

An elephant tail

Use of the amino acid supplement L-arginine following a heart attack does not improve certain cardiac functions and measurements and may be associated with an increased risk of death, according to a study in the January 4 issue of JAMA. L-arginine is a widely availa...

Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients

...sion of a brain chemical called EAAT-2 (excitatory amino acid transporter-2). EAAT-2 absorbs the neurotransmitter glutamate from the space between neurons (the synapse), thereby preventing excess neuronal excitation, which in turn can cause cell death and brain damage. Ceftriaxone, used to treat pneumonia...

Bacteria beat the heat

...vigdor Scherz, has found that a switch in just two amino acids (the building blocks of protein) can make a ...rned up differences in just two of the hundreds of amino acids making up the enzyme sequence. When the scientists replaced these two amino acids in the enzym...

Malaria, potato famine pathogen share surprising trait

...ns. A leader sequence is a group of about 20 to 30 amino acids on a protein secreted by the parasite. This sequence contains instructions on how to enter, and therefore start infecting, a plant or animal cell. In laboratory experiments, the researchers infected human red blood cells with the modified mala...

Unusual mechanism keeps repair protein accurate

...line-rich domain because it has high levels of the amino acid proline. "There was no known function for a structure like the proline-rich domain, so we at first thought it did nothing more than connect the docking region of the protein with regions three and four," Suo says. "Then by accident we lear...

Production of key Alzheimer's protein monitored for first time in humans

... drip, scientists give test subjects a form of the amino acid leucine that has been very slightly altered to label it. Inside the leucine are carbon atoms with 13 neutrons and protons in their nucleus instead of the more common 12 neutrons and protons--in scientific parlance, carbon 13 instead of carbon 12...

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