Engineered molecule amplifies body's immune response
By altering a molecule called Stat1, which is involved in cellular immune signaling, scientists have succeeded in making the molecule more responsive and thus more efficient. This old protein with a new twist may eventually be used to improve the body's defense ...New Discovery May Help Doctors Treat Infertility
...ormation to determine if a genetic mutation may be altering the function of the estrogen receptor beta. The results of this blood test, coupled with information from other medical tests and evaluations conducted by the physician, will help diagnose infertility and better determine treatment options. “Dealing...Researchers track down cause of a disfiguring bone disorder
...y represents a clear and unambiguous case in which altering noncoding genomic content has a deleterious impact on gene expression," the team reported, "demonstrating that mutations in distant regulatory elements are able to cause congenital abnormalities analogous to coding (gene) mutations." "Human genetic ...A virus-like hitchhiker may trigger bacterial meningitis
... into the bloodstream, suggests Tinsley, either by altering the bacteria or by disrupting the immune response that normally protects against it. ...Researchers Discover That Microbes Can Produce Miniature Electrical Wires
...obial nanowires that they produce. Furthermore, by altering the DNA sequence of the genes that encode for microbial nanowires, it may be possible to produce nanowires with different properties and functions. Another interesting implication of this research is that it suggests a mechanism for microbes to shar...To translate touch, the brain can quickly rearrange its sense of the body
...ght and that such updates can happen very quickly, altering within a matter of seconds how body parts and individual touch sensations are perceived. The work is reported by researchers Frederique de Vignemont, Henrik Ehrsson, and Patrick Haggard at University College London. The information that is integrat...Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
...to outsmart the immune system and how, by slightly altering one of the microbe's tools, the researchers produced what may be the first safe and effective vaccine. Both papers -- one published online July 28 in Science Express and one in the August issue of Infection and Immunity -- focus on aspects of the ty...Researchers Identify Cause of Early Bird Sleep Disorder
...lled point mutations in the genes. This means that altering a single base-pair in the gene's long DNA chain is enough to change a person's sleep behavior. Evidence from tissue culture experiments with the second gene suggests the change causes a protein -- an enzyme called a kinase that is made by the gene - ...Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
...ted the presence of an unidentified regulator gene altering the timing of erythromycin production, but could not pinpoint the specific mutation. A similar study by Kao's group identified two genes responsible for overproduction of the antibiotic tylosin. Instead of increasing the length of time that a bacter...At the molecular level, the predator is the prey
...ew traits often happens one of two ways, either by altering existing genes or by changing patterns and amounts of expression. The current Nature report shows that snakes' ability to detoxify TTX involves changes in the sodium channel gene. "That is generally the story as it is developing," Brodie said. "Ecol...Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes
...emonstrated that the pancreatic transplants aren't altering the rats' immune systems. They showed that rats with successful pancreatic transplants still reject a transplant of a different type of pig primordia, embryonic kidney tissue, if they are not given immune suppression drugs. Prior research by other s...The circadian clock: Understanding nature's timepiece
...que that involves resetting the circadian clock by altering serotonin levels, the same neurotransmitter that the anti-depressant Prozac targets. He says it could one day be possible to move people ahead eight hours simply with a pill and light therapy. All terrestrial organisms ?even single-celled organisms ...Computational Method Speeds Mapping of Cell Signaling Networks
...he environment and respond accordingly--usually by altering their behavior in some way. Cells are equipped with a sophisticated communications network that links surveillance with response, and allows the cells to perform a variety of tasks--such as growing in response to hormones, moving towards a source of ...Opposing fat metabolism pathways triggered by a single gene
...e functions of PPARs and provide opportunities for altering their function for treatment of fat metabolism disorders such as diabetes and obesity. ### Citation: Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto K (2005) Nuclear hormone receptor nhr-49 controls fat consumption and fatty acid composition in C...Key Trigger Of Opioid Withdrawal Symptoms Found
...er "could produce their therapeutic effect through altering extracellular GABA concentrations as well as directly altering the excitability of GABAergic neurons." ### Elena E. Bagley, Michelle B. Gerke, Christopher W. Vau...South America's vast pantanal wetland may become next everglades, UNU experts warn
...tlands," according to the analysis, "fundamentally altering their ecology, biodiversity and species compositio...ans to induce major environmental changes, such as altering the flood pulse by building dams or changing water quality by increasing the sediment load in rivers...UCLA scientists transform HIV into cancer-seeking missile
...irus, which normally infects insects and birds. By altering the Sindbis coat, they reprogrammed the AIDS virus, which ordinarily infects T-cells, to hunt down and attach to P-glycoproteins -- molecules located on the surface of many cancer cells. The UCLA team is the first to prove that modified HIV will targ...Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...n neuraldevelopment. The BCE mixture is capable of altering neural development,and alterations in neural development are thought to be a cause ofautism," says Jill Kreiling, first author of the paper and a member ofReinisch's lab. But Kreiling cautions, "We cannot say at this time ifthe alteration we see in c...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...n neuraldevelopment. The BCE mixture is capable of altering neural development,and alterations in neural development are thought to be a cause ofautism," says Jill Kreiling, first author of the paper and a member ofReinisch's lab. But Kreiling cautions, "We cannot say at this time ifthe alteration we see in c...