A new study of living cells could revolutionize the way we test drugs
...easure a cell’s heartbeat can be developed. "We already have some ideas about how to improve the sensitivity of the detector in water and next time we will also use a more active micro-organism such as an amoeba. Yeast is a subdued organism and doesn’t generate much activity," says Professor Geim. "Probab...Renegade RNA -- Clues to cancer and normal growth
...will be published Jan. 5 in Science. MicroRNAs, already implicated in cancer and normal development, latch on to and gum up larger strands of RNA that carry instructions for making the proteins that do all the cell's work. They are, says Joshua Mendell, M.D., Ph.D., an assistant professor in the McKusick-...Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps
...ce of more than a dozen other more distant species already in the public databases, the human HapMap, and the Human Gene Mutation Database that lists known human mutations that lead to genetic disease. "This study of the rhesus genome is invaluable because it gives researchers a perspective to observe w...... was the knowledge that existing anti-fungal drugs already target P450s as a way to treat, for example, systemic and more superficial infections caused by fungi such as Candida albicans (the causative agent of thrush). "The class of drugs called azoles are able to kill off fungal infections by blocking th...Study shows hope for early diagnosis of Alzheimer's
...cipital regions of the brains of 71 patients, some already diagnosed with Alzheimer’s and some without Alzheimer’s. Their diagnostic accuracy rate was 82 to 85 percent using the EEGs (e.g., it matched evaluations conducted at Penn 82 to 85 percent of the time). Alzheimer’s disease cannot be confirmed until a...Shedding new light on proteorhodopsin
... "Think of it like a capacitor. If a capacitor is already fully charged and you connect a battery to it nothing happens. However, if you drain the capacitor and then connect a battery, a current will flow." To observe proteorhodopsin in action and measure its effects, Liphardt and his co-authors genetic...Research on grey mould offers possible breakthrough in tomato cultivation
...grey mould. The leading company De Ruiter Seeds is already applying these methods in its breeding programme. Finkers started off with wild tomato accessions that were resistant to grey mould. When crossing the resistant wild tomato Solanum habrochaites LYC4 with the susceptible S. lycopersicum cv. Moneymake...Iowa State University botanists identify new species of North American bamboo
...xists, then comparing notes," Clark said. They already know that the closest relatives of native North American bamboos are not in Central or South America, but are in East Asia. "That's a well-known pattern of diversity in plants and animals. Plants known to be closely related that were previously f...Yale biologists 'trick' viruses into extinction
...ainst human viruses," said Turner. "A similar idea already exists in agriculture, where farmers use non-harvested 'trap crops' to lure insect pests. Because the pests prefer the taste of the trap crops, only these plants need to be sprayed, reducing the amount of pesticide use." Turner believes that simi...Infection detectives use disease 'fingerprints' to track common infections in children
...orm the analysis in their offices, researchers are already thinking about a possible way they could send in the results from the chip and get the analysis back via the Internet, for example. "Pediatricians understand that this could change the way we do things," said Dr. Ramilo, who leads pediatric infect...Putting an old drug to a new use
... quicker than for other substances, because it has already been used for years to treat patients with high blood pressure. From this we know the drug and its side-effects." An important step on the way from laboratory to clinic will be targeted pharmacological modifications of the compound to separate nif...Scientists discover stage at which an embryonic cell is fated to become a stem cell
...t that differences between the embryonic cells are already apparent at the 4-cell-stage, before the cells become partitioned between the inside or outside of the embryo. And those differences depend on the orientation and order of the very first cleavage divisions of the embryo. Professor Zernicka-Goetz s...Phthalates now linked to fat, related health risks
...emical found in everything from plastics to soaps, already has been connected to reproductive problems and now, for the first time, is linked to abdominal obesity and insulin resistance in adult males, according to a study by the University of Rochester Medical Center. The research adds to the growing suspi...Scientists find potential 'off-switch' for HIV virus
...hreat to the host." Weinberger said that drugs already exist that target other cellular enzymes, so there is reason to hope the approach will work. "There is precedent for this type of treatment," he said. Though more research will be needed to develop drugs based on the Princeton scientists' "re...Smoking ban dramatically reduces air pollution in Irish pubs
...nzene concentrations in pubs after the ban, having already established the ambient outdoor levels for benzene in Dublin. Among the bar staff, pulmonary function tests improved dramatically in non-smoking barmen post-ban; the workers also showed reductions in self-reported health symptoms. In addition, the...Cancer vaccines -- Taking a jab at cancer by stimulating the immune system
...iller T-cell response. The combined strategy has already shown great promise in studies using animal models and human cells in culture, according to the researchers. The phase I trial, which will eventually enroll 24 patients with head and neck cancer, has three experimental arms, each including a DC-b...Bioluminescence at the service of a novel cerebral imaging technique
...activity of the whole brain. Preliminary data are already available. For the first time, it is possible to draw up anatomical and functional maps of the brain (in this case, of the Drosophila) based on long-term recordings. Such maps do not yet exist for any animal species, including man. A funding ap...Failure to meet United Nations sanitation target could affect millions of the world's poorest
...t was only about $1,700, the sanitation target has already been met. According to Davis, political commitment has been a crucial factor in Myanmar, which has celebrated a National Sanitation Week each year since 1998 and has incorporated sanitation services into its national health policy. By contrast, neigh...New study may show how to forestall a fatal, virus-caused immune-system meltdown
...According to Bowick, the Pichinde experiments have already generated some therapeutic leads, thanks to the un...n experiment where we can start testing drugs that already have FDA approval,?Bowick said. “If we can go straight from discovery to drug candidates, that’s qui......rs in his lab, with Junek supplying nymphs she has already found this year. Junek is also giving him other valuable insights gained through personal observations. Last year, when the grasshoppers reached adulthood, she caught them and fed them to her chickens. The chickens readily ate them, giving Behmer...