Secrets of the sea yield stronger artificial bone
...n proliferate into the porous ceramic scaffolding, allowing old bone to fuse with new bone. We provide the body with scaffolding, and the rest of the work is done by cells." The Berkeley Lab scientists also hope to create samples that are large enough to work with artificial joints. Their ice-templated fabri...New method enables gene disruption in destructive fungal pathogen
...widely applicable and would be extremely useful in allowing scientists to investigate the key events that occur when a host interacts with a pathogen. "The development of this protocol is timely as the genome sequence of A. brassicicola is scheduled for completion in 2006. We now have in our hands a versati...Brittlestar provides new model for stem cell research
...rittlestar as a new model for studying stem cells, allowing them to do experiments that avoid the ethical issues associated with human and vertebrate research. The brittlestar, Amphiura filiformis, is a close relative of the starfish and can regenerate lost arms in a matter of weeks. Sam Dupont and Mike Tho...Gene thwarts some pathogens, gives access to others, could save crops
...ls needed to set off a relay of biochemical events allowing the plant to fight off the pathogen, Mengiste said. "Basically the BIK1 protein does this by regulating a plant defense hormone called salicylic acid," he said. "The amount of salicylic acid determines the type and level of a plant's response to the...Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
...own in the acidic environment of the cancer cells, allowing us to target these drugs within tumor cells." One key feature of molecular mechanism involves putting pores in the cancer cell's membranes and has been simulated with supercomputers by Michael F. Klein and Goundla Srinivas of Penn's Department of ...Gene variation increases SIDS risk in African Americans
... response to electrical signals they open briefly, allowing ions to flow though, then rapidly close again. When the pH falls, however, the mutant sodium ion channels tended to pop back open, delaying the cells' recovery after a burst of activity. In the heart, changes like this are known to increase the ris...Poison dart frog mimics gain when birds learn to stay away
...penalty of novelty," says Cummings. "This could be allowing diversity to take hold." The frogs Darst and Cummings studied happen to live in the same forest basin where the famous naturalist Henry Bates first described mimicry in butterflies over 100 years ago. His theory, known as Batesian mimicry, describes...Salk researchers make fast strides towards understanding how our body controls walking
...ns more quickly, speeds up the stepping movements, allowing animals to walk, run, or swim faster. ...Novel virus entry mechanism could lead to new drugs against poxviruses
...erial College London team discovered the mechanism allowing Vaccinia virus to shed its outer lipid membrane an...-fusogenic disruption of the virus outer envelope, allowing the poxvirus to enter the cell. As well as discovering how the double membrane problem is solved, ...Tumor cells that border normal tissue are told to leave
...nals that tell them to wander away from the tumor, allowing the cancer cells to establish deadly metastatic tumors elsewhere in the body. The researchers say their discovery demonstrates the importance of the tumor's environment and shows more precisely how the metastatic process occurs and might be stopped...MIT research holds promise for Huntington's treatment
...dopamine transmits signals to the corpus striatum, allowing muscles to make smooth, controlled movements. When those dopamine-producing cells die, Parkinson's patients exhibit the tremors that are characteristic of the disease. The researchers are now working on finding a more potent version of the compound ...Novel method reveals how menthol discovery could point towards new or improved pain therapies
... the membrane. When activated, the channel opens, allowing an influx of calcium ions into the axon, an electrical signal that alerts the neuron, which relays the message to the brain. Research Associate Michael Bandell, the lead author of the study, noted, "It's a well established method to mutate individua...Unraveling the mysteries of poison
.... The channels build an electro-chemical gradient, allowing nerve and heart muscle cell signals to pass. The nerve or heart muscle cell is excited, and the ion channel structure changes, developing pores which let the ions through. Different channels are open to different specific ions; for example, potassium...Macrophage signaling may affect hormone resistance in prostate tumors
...se the activity of androgen antagonists to change, allowing the expression of androgen target genes in the tumor cells. The research team describes the signaling pathway involved in this process, involving several proteins that may be potential drug targets in the future. Steroid receptors (the proteins that...Research could lead to better drugs and whiter whites
...barriers caused by the resistance to a reaction by allowing matter to 'flow through' the barrier ?a process known as quantum mechanical tunnelling. "We have provided new insight into how enzymes work from painstaking efforts of a large interdisciplinary group based on detailed experimental observations and t...Two NIH initiatives launch intensive efforts to find roots of common diseases
...hat will revolutionize the practice of medicine by allowing us to predict disease, develop more precise therapies and, ultimately, pre-empt the development of disease in the first place."Public-Private Partnership At the same time, a public-private partnership between NIH, FNIH, which is a non-profit foundat...Georgia Tech accelerates drug discovery with new IBM supercomputing cluster
...e the time it takes to complete research projects, allowing the Center more time to explore new commercial opportunities in the fields of pharmaceutical science and healthcare. ...UCLA scientists uncover mechanism of response to targeted therapy
...r cells were indeed better at taking up the probe, allowing the cancer cells to be monitored by PET scanning. Just 24 hours after treatment with CCI-779, intake of the PET probe levels dropped in the cancer cells, meaning HIF levels were falling and the drug was working. "If we can use PET scanning to follow...USC, Rice to develop bacteria-powered fuel cells
... tests on the computer will save time and money by allowing laboratory experiments to focus on best candidate approaches. "One of the hallmarks of our approach is the vigorous feedback between our computer models and our laboratory work," said Lüttge. "The computer simulations help us perform better experime...Forsyth scientists gain greater understanding of how embryos differentiate left from right
...like structures on a cell) were the primary agents allowing an embryo to correctly position its internal organs along the left-right axis. Instead, their research showed a single asymmetry mechanism linking ciliary, serotonergic (serotonin is the chemical substance involved in transmitting signals between neu...