Scientists reveal structure of gateways to gene control
...leosome and tend to face outward on the DNA helix, allowing the cell's transcription proteins to find them mor...he architecture of the DNA in the control regions, allowing us to understand much better how genes are regulated, which is important because gene regulation is ...Brain tissue reveals possible genetic trigger for schizophrenia
...rtain proteins, the microRNAs may disconnect, thus allowing protein expression to resume. Using postmortem prefrontal cortical brain tissue of people with schizophrenia and persons who had no psychiatric illness, the researchers found for the first time a significant difference in the microRNA expression...Fungal factories may save hemlock forests
...the pest population to a level that is manageable, allowing some of the trees to make seeds, grow, and survive." It's a pressing problem: In Shenandoah National Park most of the famous towering hemlocks are now dead. The adelgid has ravaged parts of Kentucky, North Carolina and the Smoky Mountains. Expand...Protein averts cell suicide but might contribute to cancer
.... It adds a base opposite the gap and then leaves, allowing the DNA-making machinery to bypass the damage and continue construction. The action averts cell suicide, but the gap ?and the stop-gap base ?might become a mutation that, in conjunction with later genetic damage, causes the cell to eventually bec...Overfishing large sharks impacts entire marine ecosystem, shrinks shellfish supply
...und that most scallops survived the ray predation, allowing the scallop population to support a fishery and still replenish itself each year. In contrast, sampling by Peterson and co-author Sean Powers in recent years—after the cownose ray population explosion—showed that the migrating rays consumed nearly al...MIT bioengineer advances survival, promise of adult stem cells
...d, preventing the stem cells from eating it up and allowing continuous EGF exposure on the cell surface. "Putting them on a scaffold is appealing because then you can control the concentration and location and so forth," Griffith said. The ceramic and polymer scaffold, which remains in the patient's body d...New imaging technique tracks traffic patterns of white blood cells
...ital observations of leukocyte behavior in vivo by allowing the near-simultaneous observation of cell surface markers and microdomains." Researchers explored various mouse models including that of Sickle Cell disease which is a common inherited blood disorder in the United States, affecting 72,000 American...Dig deeper to find Martian life
...surface of Mars and at regular depths underground, allowing the calculation of cell survival times. The team took the known radiation resistance of terrestrial cells combined with the annual radiation doses on Mars to calculate the survival time of dormant populations of the cells. Some strains are radiati...U of MN researchers turn cord blood into lung cells
...h allows the air sacs in the lungs to remain open, allowing air to move in and out of the sacs. The cells are also responsible for helping to repair the airway after injury. "In the future, we may be able to examine cord blood from babies who have lung diseases, such as cystic fibrosis, to do more research...Microbes compete with animals for food by making it stink
...o make these resources repugnant to other animals, allowing microbes to consume them instead. To test whether aged meat attracts fewer consumers than fresher meat, researchers baited crab traps with menhaden -- a fish typically used for bait -- that had been rotting in a pool of warm water ?some of it for o...Dopamine used to prompt nerve tissue to regrow
...t cause any tissue scarring or nerve degeneration, allowing the nerve to grow in a hostile environment post injury. When ready for clinical use, the polymer would be implanted at the damaged site to promote nerve regeneration. As the nerve tissue reforms, the polymer degrades. Wang's team found that do...One-of-a-kind imaging probe reveals secrets useful for drug discovery
...stronger magnetic fields to study smaller samples, allowing scientists to study molecules atom by atom. But what made this particular method unique is not the extreme power of the magnet, which at 600 megahertz is fairly standard, but the extreme sensitivity of the probe - the component that is inserted into...Unique gene regulation gives chilly bugs survival advantage at bottom of the world
...ecial proteins that minimize environmental stress, allowing them to withstand a range of intense environmental conditions in one of the world's harshest environments. Scientists found that adult midges (Belgica antarctica) lose their ability to continually express these protective heat-shock proteins. Inste...NASA satellite data helps assess the health of Florida's coral reef
... provides more detail than traditional satellites, allowing us to detect conditions down to hundreds of meters - the size of individual reefs," said Christopher Moses, University of South Florida, Tampa, Fla. Researchers also used the recently developed Landsat-based Millennium Coral Reef Map http://seawif...NHGRI aims to make DNA sequencing faster, more cost effective
...f sequencing a mammalian-sized genome to $100,000, allowing researchers to sequence the genomes of hundreds or even thousands of people participating in studies to identify genes that contribute to common, complex diseases. Ultimately, NHGRI's vision is to cut the cost of whole-genome sequencing to $1,000 or ...Comprehensive model is first to map protein folding at atomic level
...ork should open new vistas in protein engineering, allowing rational control of not only protein folding, but also the design of pathways that lead to these folds," says Shakhnovich, who has studied protein folding for nearly two decades. "We are also using these techniques to better understand two fundamenta...Tarantula venom and chili peppers target same pain sensor
... compounds bind to it, the receptor channel opens, allowing a stream of charged sodium and calcium molecules to rush into the nerve cell. This generates an electrical signal that travels to the brain to produce pain. The researchers examined venoms from 22 spider and scorpion species whose bites are known ...PET imaging shows young smokers quick benefit of quitting
...d over time, plaques can narrow coronary arteries, allowing less blood to flow to the heart muscle. Rupture of these plaques may result in a stroke, heart attack and death. It's generally known that the risk of death from coronary artery disease is up to six times higher in smokers than in nonsmokers, and...Origin of inherited pain disorder pinpointed
...used by a nerve impulse, these channels snap open, allowing sodium to flow across the cell membrane, further propagating the nerve impulse. Rapid, precise activation and inactivation is key to their normal operation. In their studies, the researchers sought to understand the basis of PEPD, which is characte...Clue found to Epstein-Barr virus' ability to form and sustain tumors
...rotein binds this 25-amino acid segment of EBNA-1, allowing transcription of viral and cellular genes regulated by EBNA-1 to occur. Hammerschmidt and Sugden are now trying to identify the cellular protein. "If we can identify this protein, it will be easier for us to develop assays to screen for small mole...