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Dinosaur DNA? New Patent Covers Degraded DNA recovery

...uting genes from "degraded" DNA samples, and could allow scientists to reassemble everything from prehistoric, extinct animals to unsolved crime scenes. "This discovery, when properly applied by our scientists, brings us closer to our goal of reconstructing genetic history. We now have the picture on the ...

Molecular machine may lead to new drugs to combat human diseases

...crystal structure of this Group I intron also will allow scientists to form models of hundreds of other introns in the same family and provide possibilities for new treatments for a wide variety of diseases, she said. Other scientists now will use the information gleaned from this study in an attempt to d...

Spider Venom Could Yield Eco-Friendly Insecticides

...nteraction with insect ion channels. (Ion channels allow the movement of ions -- small charged molecules -- across cell membranes.) His next challenge is to use this information to design insecticides that specifically target insect pests without affecting vertebrates. One approach is to create chemical i...

New imaging method gives early indication if brain cancer therapy is effective, U-M study shows

...tely predict the treatment response early on could allow some patients to switch to a more beneficial therapy and avoid the side effects of a prolonged and ineffective treatment," said Brian Ross, Ph.D., professor of radiology and biological chemistry at the U-M Medical School and a member of the U-M Compr...

Gene variations explain drug dose required to control seizures

...rapidly for some patients. Such a trial might also allow physicians to identify patients who might safely take a smaller dose, thereby minimizing their risk for adverse side effects, he added. The findings in epilepsy set the stage for scientists to evaluate other conditions in which gene-based diagnostic...

BRCA1 causes ovarian cancer through indirect, biochemical route

...ase, it would mean that mutation of the gene would allow the cell it's in to grow out of control and create a tumor. Instead, Dubeau notes, "What we've shown is that the gene actually acts indirectly, that it disrupts interactions between different cell types." The well-known breast cancer gene, BRCA1, no...

Purdue proves concept of using nano-materials for drug discovery

...is membrane are nanometer in scale, so they do not allow proteins to readily pass through the membrane but will allow smaller molecules to pass. "This allows us to do separation right in the reactor, which means we ca...

Researchers find missing genes of ancient organism

...ng them. The regions on the separate pieces, that allow them to find each other and splice, are somewhat similar to internal sequences found in tRNA genes of more complex organisms., These regions, termed introns, are sequences that are cut out of whole gene transcripts during the process of tRNA maturati...

Same mutation aided evolution in many fish species, Stanford study finds

...antage of the same genetic trick time and again to allow freshwater species to shed their burdensome body armor and transform into a lighter, spryer fish. This is among the first times scientists have shown that the same genetic change is responsible for an evolutionary adaptation in disparate populations....

Development of portable infectious disease detector

...Pyle. "We are developing a devicethat we hope will allow medical professionals and HIV patients tomanage their disease in a way that is similar to how diabetes patientscan monitor their condition since the introduction of home bloodglucose detectors." The collaboration's goal is to produce its firstportabl...

Researchers add new tool to tumor-treatment arsenal

...ng agents can be toxic, and doses that are too low allow for DNA repair and further cell growth. Thus, says Dr. Thomas, there is need for drugs that can sensitize cells to lower doses of DNA-damaging agents to guarantee cell death, but without the toxic side effects. The researchers studied the results of...

An entropy-based gene selection method for cancer classification using microarray data

...t. The selected gene set should be small enough to allow diagnosis even in regular clinical laboratories and ideally identify genes involved in cancer-specific regulatory pathways. Here an entropy-based method is proposed that selects genes related to the different cancer classes while at the same time red...

Nano-Probes Allow an Inside Look at Cell Nuclei

...cell cycle control. The long-lived probes may also allow researchers to track the effectiveness of disease-fighting drugs that target these processes. "We could determine whether a drug has arrived where it is supposed to, and if it is having the desired impact," says Chen. The first enduring look into t...

First real-time view of developing neurons reveals surprises, say Stanford researchers

...echnical savvy involved in monitoring neurons will allow researchers to conduct experiments that were previously not possible. While the research showed neurons firing in a more mature way than expected, it also revealed that neurons take their time establishing the final wiring of the brain. Young neuron...

The BIOS Initiative - open source biotechnology is born

...hese tools, and the precedent they establish, will allow the public-sector, small to medium enterprises and even large firms worldwide to explore new business models and begin a new era of transparent and cost-effective innovation in life sciences. The technologies include TransBacter, a new method for tr...

UCSD discovery may help extend life of natural pesticide

...rogram? If the field can figure this out, it might allow for the engineering of toxins that can utilize either type of receptor alternatively, such that host resistance would require the mutation of both receptor types. This means that resistance would be exponentially less probable." ...

RNA project to create language for scientists worldwide

...ic concepts relating RNA structure and function to allow RNA scientists worldwide to communicate with one another as well as to integrate different kinds of information they obtain about RNA molecules," explained Dr. Neocles Leontis, a Bowling Green State University chemistry professor chosen by the RNA So...

Falling ants glide back to trunk to avoid dangers of forest floor

...ich, when combined with abdominal movements, might allow the ants to reorient in midair. They also have an unusual flattened head with flanges that could act as a rudder, Dudley said. "My guess is that, by gliding backwards and using their legs and also their flat head with flanges, they could steer," he ...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

...00K is the first in a family of products that will allow researchers at Karolinska Institutet to perform high-density genome scans and genome-wide association studies on the genetics of complex diseases. About Affymetrix: Affymetrix scientists invented the world's first high-density microarray in 1989 and...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...o the antibodies the normal immune system does not allow to be made," Haynes said. The results provide a new goal for future HIV research, Haynes said. "We can focus on trying to redirect the response to HIV outer coat proteins from innate B cells to adaptive B cells. Alternatively, we can develop ways to...

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