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Tag: "agent" at biology news

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...he many respiratory diseases for which a causative agent isunidentified, and may have a role in Kawasaki disease, the most commoncause of acquired heart disease in children in developed countries. In the first of two studies, Jeffrey S. Kahn and co-workers at YaleUniversity used molecular probes targeting...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...e, a finding congruent with the idea ofNedd4 as an agent of endocytosis. Nedd4’s role as a suppressor of Notchwas illustrated even more plainly when the lab showed that inhibitionof Nedd4 results in the upregulation of ligand-independent activationof the Notch pathway.Nedd4’s place in the greater scheme of...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...ssing enzyme" from the biosynthetic pathway for an agent used by the bacteria to scavenge iron. The resear...ournal. Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible for more morbidity in humans than any other bacteria. The emergence ...

Leukemia Drug Breakthrough Study In New England Journal Of Medicine

...MDS following his laboratory observations that the agent improved the growth of red blood cell precursors from MDS bone marrow. Celgene will submit the seminal findings of List's phase I trial - along with data from two recent confirmatory phase II clinical trials performed nationwide involving more than 3...

Jefferson Virologists Coax HIV Out of Hiding

...-7,?he says. “We don’t know why, but it isthe best agent in terms of its ability to stimulate HIV out of latencythat we’ve seen in the last 15 years.?They found that the virus wasstimulated to higher levels and was activated in more patients thanwith other compounds. Dr. Pomerantz’s group also discovered t...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

...one as far as we can in animalstudies, I hope this agent might be tested clinically both to treatHER2/neu breast tumors, and to prevent them from spreading.?Up to one-third of human breast cancers are associated withover-expression of the HER2/neu cell surface receptor protein, whichcontinuously “tells?the...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

...one as far as we can in animalstudies, I hope this agent might be tested clinically both to treatHER2/neu breast tumors, and to prevent them from spreading.?Up to one-third of human breast cancers are associated withover-expression of the HER2/neu cell surface receptor protein, whichcontinuously “tells?the...

Researchers add new tool to tumor-treatment arsenal

...rs studied the results of combining a DNA-damaging agent called cisplatin with RAD001, a derivative of the ... trials. RAD001 lowers the amount of DNA-damaging agent needed by blocking p53's DNA-repair function, automatically killing the cancer cells when agents lik...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...chondria in the cell. It's no longer a cooperative agent in a collection of cells but becomes malicious, tries to get outside the area, and hijacks the respiratory machinery of a cell." The biocavity laser It is these changes - a kind of beefing-up of the criminal forces - that Gourley's device, called a...

Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth

...nd of the potential importance of an environmental agent in risk of breast cancer," said Nie. "Further examination of PAH exposure in early life is clearly warranted." The UB researchers currently are examining whether genetic polymorphisms involving PAH metabolism may modify the risk, if lifeline cumulat...

NASA links nanobacteria to kidney stones and other diseases

...ium phosphate centers of kidney stones. This novel agent has also been detected in related conditions, including Alzheimer's disease, heart disease, prostatitis, and some cancers. Further testing for the presence of NB in human bodies can help reduce the risk for kidney stone formation in astronauts and wo...

Substance protects resilient staph bacteria

...ay elsewhere on Bacillus anthracis--the infectious agent of anthrax, which also produces PGA--will complement their work. The report of the study, led by Michael Otto, Ph.D., will appear in the March edition of The Journal of Clinical Investigation and is now available online. Collaborators, all scientist...

A human parasite with a streamlined mitochondrion

... humans--such as Entamoeba histolytica, the causal agent of amoebic dysentery--live in environments that are too oxygen poor to support this process. Nevertheless, Entamoeba still contains a somewhat mysterious organelle, called a mitosome, that is evolutionarily derived from mitochondria. As reported by r...

Microbial forensics: The next great forensic challenge

...llenge." Murch will present the paper, "Biothreat agent forensics: Seeking attribution using an adaptive, integrated approach (ComSci 6)," at 11:30 a.m. Monday, March 14, in Convention Center room 25C. The topic is also addressed in an article recently accepted for Applied and Environmental Microbiology,...

Buying Time Through Hibernation on Demand

... of saline solution mixed with trace amounts of an agent that would interfere with the body's ability to us... 'better living through chemistry' ?it's simply an agent that all of us make in our bodies all the time to buffer our metabolic flexibility. It's what allows...

U-M team recovers ancient whale in Egyptian desert

... of saline solution mixed with trace amounts of an agent that would interfere with the body's ability to us... 'better living through chemistry' ?it's simply an agent that all of us make in our bodies all the time to buffer our metabolic flexibility. It's what allows...

Strongest proof yet found for prion hypothesis

...lopathies" (TSEs) are transmitted by an infectious agent composed only of a malformed protein, and not a vi...pproach eliminates the possibility that some other agent might be causing the disease. In a paper scheduled to appear in the journal Cell on April 21, the U...

Harmful chemicals may reprogram gene response to estrogen

...is study, however, indicates that an environmental agent can actually change or reprogram the gene so that it functions differently. "This study is telling us that an environmental reprogramming of a normal response, combined with an inherited gene defect, work together to promote cancer," said NIEHS Dire...

Discovery may lead to better Candidiasis drug

...e how histatin, the naturally occurring antifungal agent in saliva, kills the oral pathogen Candida albicans, the fungus responsible for most HIV-related oral infections. Researchers led by Mira Edgerton, D.D.S., Ph.D., discovered that histatin binds to a specific membrane protein called TRK1p, which regu...

First technology to remove prions that cause vCJD from blood launched

...emoves infectious prions that may be the causative agent of vCJD from red cells, the most commonly transfus...how that it removes 99.9 percent of the infectious agent from red cells. A filtration approach to prion protection offers significant advantages over other ...

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