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Tag: "after" at biology news

Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer

... nodes and chest wall) to a course of chemotherapy after radical mastectomy in premenopausal women with lym...he effectiveness of locoregional radiation therapy after mastectomy in moderate-risk patients, we strongly urge that a randomized controlled trial be mounted...

Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down

... nodes and chest wall) to a course of chemotherapy after radical mastectomy in premenopausal women with lym...he effectiveness of locoregional radiation therapy after mastectomy in moderate-risk patients, we strongly urge that a randomized controlled trial be mounted...

Jump-starting T Cells In Skin Cancer

...istics of the T cell populations that are expanded after vaccination may help in the development of more ef...alled MAGE-3. In one patient whose tumor regressed after vaccination, the authors found significantly more T cells specific for non-vaccine tumor proteins th...

A new mechanism of regulating RNA degradation

...many of the tools cells use to regulate genes work after transcription, by moderating the activity and the life span of the RNA itself. One major pathway for such post-transcriptional regulation is called nonsense-mediated decay (NMD). Originally NMD was thought to destroy incorrectly transcribed or other...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...many of the tools cells use to regulate genes work after transcription, by moderating the activity and the life span of the RNA itself. One major pathway for such post-transcriptional regulation is called nonsense-mediated decay (NMD). Originally NMD was thought to destroy incorrectly transcribed or other...

Source of molecular triggers in cutaneous T cell lymphoma identified

...le of LC." The study also showed that CTCL cells, after stimulation by LC, become functioning regulatory T (Treg) cells that suppress the immune responses of normal T cells to microbial agents. This may explain the susceptibility of patients with extensive CTCL to opportunistic infections. "Through under...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

...nt methods that infusethe cells into the structure after it has been built."The problem is getting cells into the interior of these constructionsas they naturally stick to the sides of whatever they are beinginserted into. If they stick to the sides then this limits the numberof cells which can grow into t...

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...UV-induced DNA damage, which for example may occur after excessiveunprotected sunbathing, can lead to cellular death ?recognized assunburn of the skin ?and may cause permanent changes in the DNA(mutations) that ultimately can result in the onset of skin cancer.Thus far it was not clear how the two major ty...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

...l lavage (CVL) fluid collected before and one hour after administration of a single intravaginal dose of PR...e inflammation. Analyses showed that CVL obtained after the application of PRO 2000 gel reduced both HIV and HSV infectivity by at least 1000-fold compared ...

Priming embryonic stem cells to fulfill their promise

...or Regenerative Medicine. The institute wascreated after California voters in November approved Proposition 71, ameasure that authorized the state to borrow $3 billion to fund stemcell research over the next 10 years."I'm really excited about the stem cell applications of our newtechnology," said Bhatia. "...

Growth in the sea comes down to a struggle for iron

...rbon with them. The Kilo Moana returned to Hawaii after spending 42 days at sea. Early results suggest that the struggle for iron may indeed follow something like what happens in the soil. Wells and his colleagues are evaluating the data they collected and conducting additional laboratory experiments. UM...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...the researchers tested their blood glucose (sugar) after meals. At age 2 months, the results were similar between the two groups. But over time, differences began to unfold. When 4 months old (comparable to human adolescence), the low-birth-weight babies began showing higher levels of blood glucose. "By 6 ...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...lunteers' blood will be measuredbefore, during and after administration of the drug or placebo. Thestudy is... the number of white blood cells to fightinfection after chemotherapy; in healthy individuals serving as bonemarrow donors to stimulate the bone marrow to re...

Controversial drug shown to act on brain protein to cut alcohol use

...The discovery that Ibogaine reduced binge drinking after a period ofabstinence was an exciting finding for us because this is the type ofbehavior in alcoholics for which very few effective drugs exist," Janaksaid.The scientists confirmed in a cell model that Ibogaine stimulated GDNFactivity. Finally, they ...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...ell and begin replicating. The structure of gp120 after it binds to the CD4 receptor and changes its shape was solved several years ago by another group. Harrison and Chen have now described gp120's structure before the shape change, yielding vital before-and-after information on how the molecule rearrang...

Antarctic ice shelf retreats happened before

...cided with a shift in ocean currents that occurred after a long period of warmth. Whilst rising air temperatures are believed to be the primary cause of recent dramatic disintegration of ice shelves like Larsen B, the new study suggests that the ocean may play a more significant role in destroying them tha...

Anti-bacterial additive widespread in U.S. waterways

...lly no idea of whatexactly happens to the compound after we flush it down the drain," saidthe study's lead author, Rolf U. Halden, PhD, PE, assistant professorin the School's Department of Environmental Health Sciences andfounding member of its Center for Water and Health.The nationwide assessment of tricl...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...tion," says Epstein. "We have named them pangenes, after the Greek god Pan and Peter Pan, who were able to orchestrate complex events while never growing old." Epstein thinks that this concept may also be important for understanding the cell of origin for a number of tumors. Pax3 is known to be involved i...

Timing is everything: First step in protein building revealed

... its relative as the ribosome complexassembled and after RNA was added to the mix."We weren't even sure the two fluorescent molecules would be closeenough together to create a FRET signal at all," says Maag. "We werevery pleased just to be able to monitor it, and then we were surprisedand pleased by what w...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

...c markers are clinically available to doctors, and after large-scale trials testing early intervention are ...reatment and have a lifespan of more than 20 years after diagnosis. Since the disease most often strikes older adults, the patients whose disease follows thi...

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