Genetic therapy reverses nervous system damage in animal model of inherited human disease
...disease in cats. This is the first genetic disease affecting the central nervous system to be successfully treated in an animal larger than mice and rats. If this approach can be successfully applied to humans, say the researchers, it might one day treat an entire class of diseases called lysosomal storage dis...Canada approves marijuana-based pain spray
...system and is the most common neurological disease affecting young adults in Canada. Approximately 50,000 Canadian men and women have the disease and each day approximately three more people are diagnosed. MS is most often diagnosed in people between the ages of 20 to 40 years of age. ...Alzheimer's cognitive decline slowed
... Alzheimer's disease, a progressive brain disorder affecting memory, learning, attention and other cognitive processes. "If validated in further clinical trials, this would represent a substantially more effective therapy than current treatments for Alzheimer's disease," said Mark Tuszynski, M.D., Ph.D., UCSD...Researchers identify protein crucial for survival of Lyme-disease bacterium
...ng a number of candidate genes he thought might be affecting the survivability of Bb within its hosts. The research team had hypothesized that the elimination of the gene would somehow impact the pathogenesis of Lyme disease in mammals, but they found no evidence of that. Knockout bacteria not only survived wi...Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
...ant boosts research into climate and other factors affecting salmon in the Northeast Pacific and determining such things as how much habitat -- parts of streams or entire watersheds -- is needed to sustain salmon. Puzzles include Alaska's Kvichak River, the world's most important salmon-producing river. It ha...Discovery Promises Simpler Therapy for Sickle Cell Disease
...s for symptoms of sickle cell disease, a condition affecting one in every 600 African-Americans, has resulted from a study by researchers at Duke University Medical Center and Howard Hughes Medical Institute (HHMI). Their findings may lead to a new, more direct method for treating the disease, they said. Thei...Scientists discuss improved biopesticides for locust control in West Africa
...8 years. The pests invaded the region last summer, affecting millions of acres of farmland. The locusts are in recession now because they do not breed in the dry season, but when the annual spring rains begin, they are expected to return. Participants at the seminar included ministers of agriculture from othe...How the environment could be damaging men's reproductive health
...rther evidence that environmental factors could be affecting men's reproductive health. The studies, published...curring because changing environmental factors are affecting the reproductive development of male foetuses. Babies born with undescended testes are at higher ri...Potential treatments for neurofibromatosis
...fibromatosis occur in one in 4,000 births, equally affecting both sexes and all races and ethnicities. It is the most common neurological disorder caused by a single gene. Some NF 1 mutations are inherited, but the NF1 gene is so large that many mutations occur spontaneously rather than being passed from paren...Asthma gene clusters identified
...ma is the most common chronic disease of childhood affecting 20 million Americans, according the Centers for Disease Control. Experts know that environmental factors can lead to asthmatic conditions in children, but they also know that genetics contributes to susceptibility. There are no cures for asthma, but ...Unprecedented water level rise in Somalia
...ty and mobility of the population around the city, affecting daily activities such as commuting to work, school and accessing hospitals and markets. The floods affected at least 170 households. ...International HapMap consortium expands mapping effort
...f executive of The SNP Consortium. In addition to affecting risk of disease, genetic variation has been shown to affect the response of people to therapeutic drugs, toxic substances and environmental factors, and the HapMap can assist in the identification of those variants. Since not all genetic variants are...Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
...cific category of prostate cancer cell,potentially affecting the treatment efficacy for a subset of prostatecancers.According to a study published in the January 1 issue of CancerResearch, such prostate cancer cells proved to be vulnerable toexposure to the chemical BPA (bisophenol A), an industrial chemical a......t these analogues is that they do all this without affecting primary tumor cells, or their blood supply," Dr. Huang said. "To our knowledge, that's a real first." Exact mechanisms remain unclear. "Obviously, these compounds are targeting some step in the cell-migration process," Dr. Huang said. The activity ...Spider Venom Could Yield Eco-Friendly Insecticides
...ides that specifically target insect pests without affecting vertebrates. One approach is to create chemical insecticides that mimic the action of spider toxins. Many insects have developed immunity to DDT and other chemical controls because most insecticides are neurotoxins that act against only a small numbe...Iron Deficiency Sparks Dramatic Changes In Gene Expression
...evalent and severe nutritional disorderworld wide, affecting more than 2 billion people. The most widelyrecognized symptom is anemia, in which too few red blood cells areproduced, and the body is deprived of oxygen needed for energymetabolism. Iron deficiency causes wide-ranging symptoms from fatigue,weakness ...Plants, animals share molecular growth mechanisms
...these hairs, or trichomes, readily show when genes affecting actin filaments are askew and causing altered growth. The researchers previously had learned that a large protein complex, known as WAVE, activated ARP2/3, but they didn't know specifically which WAVE protein was the actual switch. Their latest rese...Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
...taking insulin injections. In type 2 -- a disorder affecting an estimated 18 million Americans -- the pancreas doesn't make enough insulin or the body's cells develop a resistance to its effect. Without insulin, glucose cannot get into cells to provide energy. Normally, insulin levels rise or drop in response...