miRNA-mediated silencing of mRNAs
... of whether miRNAs silence gene expression without affecting mRNA levels has been controversial, and conflicting results have been reported in the literature. Dr. Izaurralde explains that, "Our findings reveal that miRNAs silencing gene expression by at least two independent mechanisms: by repression of transl...Mechanism for neurodenegerative diseases linked to transport proteins
...untington's, it is a rare but devastating disease, affecting one in 40,000 people, usually between the ages of 30 and 50. Huntington's strikes about four times as many. Neurodegenerative diseases like SBMA are caused by the lengthening of part of a gene that encodes repetitions of the amino acid glutamine in ...Loosen up, DNA: Leukemia gene changes genetic packaging
...s have thought, exerting control over our genes by affecting whole swaths of chromosomes in global fashion, according to a paper in the September issue of Nature Genetics and appearing online August 6. While the research involving a cellular signaling system known as JAK/STAT focused on complex questions inv...Gorilla susceptibility to Ebola virus: the cost of sociality
...e findings offer a unique glimpse into the factors affecting the threat the deadly virus poses to great apes. The work is reported in the July 12th issue of the journal Current Biology by a team of researchers including Damien Caillaud and colleagues from the University of Montpellier and the University of R...Funding and bureaucracy, not access to journals, are chief obstacles to scientific productivity
... out what researchers thought were the main issues affecting their productivity. This, together with an analysis of the peer-reviewed literature enabled the team to identify a list of 16 key factors. Online polling methods in conjunction with conjoint analysis techniques were used to establish the relative p...Metal homeostasis research in plants will lead to nutrient-rich food and higher yielding crops
...he development of nutrient-rich seed, beneficially affecting human nutrition and health. This research should also lead to agronomic benefits such as increased seedling vigor, higher crop yields and resistance to disease," Guerinot said. ...Ten years later, Dolly is still making headlines
...ientists will discuss a variety of critical issues affecting pharmaceutical biotechnology including Biogenerics, a field that is being hailed as the next revolution in healthcare. "At AAPS, we are committed to tackling the latest issues ?even the toughest issues ?and exposing our members to disparate points o...Beekeepers work hard for the honey, despite changing tupelo forest
...otic pests, land development and other factors are affecting tupelo honey production, an important regional industry that contributes about $2.4 million a year to Florida's economy. The researchers' findings will allow beekeepers to develop collective strategies to defend their livelihood, Watson said. That'...Pollution threatens coral health by preventing lesions from healing, UCF study shows
...trying to find out what stresses them and how it's affecting coral health." If the researchers can determine the specific causes of pollution that are harming coral, it then will be up to governments, organizations and residents to decide whether it's worth the cost of solving whatever problems are discovere...Tiny airborne particles are a major cause of climate change
...provide a comprehensive picture of how they may be affecting our climate. Cloud formation is dependent upon the presence of small amounts of aerosols such as sea salt and desert dust. These tiny particles serve as the seeds around which water vapor in the air condenses, forming tiny water droplets that rise...Novel therapy combinations gain ground in treating hepatitis
..., hepatitis has become a worldwide health problem, affecting millions of people in the U.S. and abroad. Researchers are experimenting with combinations of anti-inflammatory medicines like interferons to improve hepatitis symptoms. In research presented today at Digestive Disease Week® 2006 (DDW), new combina...How IVF could be causing genetic errors in embryos
...ring embryos in the laboratory during IVF could be affecting embryos adversely. "Emerging new evidence shows th...nt to understand why these techniques appear to be affecting the imprinting of these genes. We hope this understanding will enable the scientific community to ma...Wild bees and the flowers they pollinate are disappearing together
...two are locked in a vicious cycle in which each is affecting the other. It's also not clear as of yet what the ultimate causes of the declines are, although land use change, agricultural chemicals and climate change may be important factors. The researchers hope to clarify these issues with follow-up studies....Researchers develop flood-tolerant California rice
...es the plant's oxygen and carbon dioxide supplies, affecting photosynthesis and respiration. Submerged, the plants lack the gases needed to produce sugar for cellular energy, resulting in death if submergence persists beyond four days. Bailey-Serres notes that access today to information about the rice geno...Virtual realities against pain
... amount of attention given to the harmful stimulus affecting the perception of the pain. Distraction techniques are based on the patient's limited capacity for attention, resulting in a reduction in the patient's attention to the stimulus and therefore a reduction in the stimulus itself. It was assumed that...Scientists stop autoimmune disease without shutting off immune system
...een skin cells. Thus, it stops the disease without affecting the immune system. "There are a number of companies developing inhibitors of the p38 enzyme for treating rheumatoid arthritis and psoriasis," Rubenstein said. "Our study suggests that those same drugs might be valuable in treating pemphigus vulgari...Matrilin-3 gene discovered to prevent onset of osteoarthritis
...haracterized by a breakdown in cartilage, commonly affecting the knees, hips and lower back. While younger people can develop osteoarthritis from joint injuries, the disease most often occurs in people over 65. The causes of osteoarthritis are not known, but they are believed to be both genetic and environment...UF scientists test improved gene therapy method for hereditary heart conditions
...e heart that is aimed at treating genetic diseases affecting the heart," Byrne said. "It's efficient and long lasting. One of the other distinguishing features of our research is it's probably the first to demonstrate a physiologic correction of a genetic cardiac abnormality." Additional tests in rhesus monk...Afghanistan to protect wildlife and wild lands
...ldlife populations, rangeland status, and diseases affecting both livestock and wildlife such as Marco Polo sheep; working with local communities to help them sustainably manage their natural resource base; and setting up a wildlife monitoring program. "Conserving Afghanistan's unique biological diversity is ......,000 individuals, is a complex disorder, primarily affecting the liver, heart, eyes, face and skeleton. Some patients with Alagille syndrome have very mild symptoms or isolated problems, while others may have severe, life-threatening heart or liver defects. Both the JAG1 and the NOTCH2 genes participate in t...