Origin of inherited pain disorder pinpointed
...y first performed a detailed genetic comparison of affected and unaffected members of one large family that sh...likely culprit. Further analysis of the gene in 11 affected families and two sporadic cases, indeed, revealed that mutations in SCN9A are responsible for the di...Cocaine high caused by interference in neuronal receiving stations
...yzed whether this interaction between D2R and NR2B affected the rats' behavioral response to cocaine—specifically the hyperactivity and intensive sniffing and biting the drug elicits in the animals. They found that drugs that either activated the D2R subunit or inactivated the NR2B subunit tended to enhance s...Controlling antibiotics and antibiotic resistance in hospitals
...ospital did to control antibiotic use and how this affected the rate of antibiotic resistance. "We saw in this study, as in other work we have done, that antibiotic resistance is increasing rapidly. This increase is seen in all types of hospitals across the country - large and small, teaching and non-teach...What does the public really know about HPV?
...us. How the vaccine was presented greatly affected women's intentions to vaccinate. When women read that the vaccine protects only against cervical cancer, 63 percent indicated they were "very likely" or "somewhat likely" to get vaccinated, compared to 43 percent of women who read that the vaccine p...From a lowly yeast, researchers divine a clue to human disease
...researchers may be able to identify specific genes affected in the human Sen1-linked neurological disorders. ...Drug can quickly mobilize an army of cells to repair injury
...xture of many cell types from bone marrow into the affected area." The research group has also shown that aft...oth drugs induced new blood vessels to grow in the affected legs of the mice, and combining the drugs had the greatest benefit. "We are now working to set up a...Small, smaller, smallest -- The plight of the vaquita
...lifornia were offered $(US)1 million to compensate affected fishermen. Another big step will be to convince the relevant State Governments of the Upper Gulf to support actions proposed by an international vaquita recovery team. These Governments have argued that no action should be taken until a second survey...Rising ocean temperatures, pollution have oysters in hot water
...tolerance in the oyster, Crassostrea virginica, is affected by cadmium," was carried out by Lannig, of the Alfred Wegener Institute for Polar & Marine Research, Bremerhaven, Germany, and Jason Flores and Inna Sokolova, of the University of North Carolina at Charlotte. The work was done in North Carolina. ...SARS: No evidence that any of the treatments worked
... The WHO group wanted to know how these treatments affected the virus outside the body ('in vitro') and whether it helped the condition of patients and reduced the death rate, especially in those patients who developed a dangerous complication called acute respiratory distress syndrome. Researchers conducte...Climate change creates dramatic decline in red-winged black bird population
...ore female eggs typically hatch, so that shift has affected the population sex ratio." Over the years, Weatherhead's team has put bands on the legs of thousands of red-winged black birds in order to track their nesting habits. They winter in southeastern United States. In mid-July they become gregarious an...Report calls for improved monoclonal antibodies against solid tumors
...s to effect a maximal change in the tumor.?This is affected by several factors, including the characteristics of the tumor, the antibody, and the target. “The complexity of this problem?can be illustrated in the authors?discussion of antibody affinity. If an antibody binds too tightly to a surface antigen, th...Queen bee promiscuity boosts hive health
...ived from multiple fathers were significantly less affected by the disease several months later. The findings have implications for beekeepers, whose honeybees bring revenues of about $20 billion a year in the United States for pollinating services. Beekeepers could boost the health of their colonies, say t...High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping
...vec and Tarceva, respectively, which shut down the affected oncogenes. The test involves taking a sample of fresh or frozen tumor, amplifying its DNA, and then searching for 250 known mutations in 17 oncogenes. (These include members of the ras, EGFR, pi3 and c-kit kinase families, among others.) To check p...Leading reason for corneal transplants comes into focus
...terns in families with relatively large numbers of affected individuals and trace genetic traits co-inherited or "linked" with the disorder. Researchers search for a common location for all the linked traits until they wind up with a single chromosome address. In his latest study, Gottsch used not only li...Resistance and genetic sensitivity to sleeping sickness
...ted: some show Glossina fuscipes gorged with blood affected by classical chronic forms of the disease; others bear severe rapidly developing forms; still other people show no symptoms of human African trypanosomiasis, in spite of a long period of infection. This diversity in host clinical presentation in reac...Human stem cells delay start of Lou Gehrig's disease in rats
...ee that the grafted stem cells were not negatively affected by the degenerating cells around them, as many feared introducing healthy cells into a diseased environment would only kill them," says Vassilis Koliatsos, M.D., an associate professor of pathology and neuroscience at Hopkins. Although all the ra...Public Library of Science to launch new, open access journal on neglected tropical diseases
...d health and research capacity in the regions most affected by neglected tropical diseases," said Dr. Hotez. "Anyone with a computer and Internet access will have free access to the journal, and may freely distribute or translate its contents." The journal will be published by the Public Library of Science...For crickets, parasitic flies can stop the music
... that the danger posed by the flies has apparently affected when crickets sing. In experiments with Southeastern U.S. field crickets, known scientifically as Gryllus rubens, they discovered that considerably fewer male crickets sing in the autumn when the parasitic flies are abundant. They also found that fem...Adolescent but not adult hamsters are more aggressive on low dose of fluoxetine
...tentially threatening situation, it differentially affected the juveniles. The effects of fluoxetine on aggressive responses appear to be specific to both age and dose. The authors say their data add to growing evidence that during puberty, the brain is still maturing and, says Taravosh-Lahn, "could possi...Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack
... as well as many factors about the disease and the affected population. In constructing these models, Longini and colleagues begin with assumptions about how people interact and how the virus spreads. They also introduce and evaluate the effectiveness of various intervention strategies. The study represents...