Viral 'fitness' explains different resistance patterns to aids drugs
...esearchers found that NNRTI-resistant virus has an advantage over sensitive virus even at very low levels of adherence. This happens because only a single mutation is required to create high-level NNRTI resistance and these mutations have little impact on the virus's ability to replicate. PI-resistant virus, i...Variation in bitter-taste receptor gene increases risk for alcoholism
... As part of this investigation, Goate's team took advantage of available genome sequence databases to speed work in identifying and studying genes on chromosome 7. She says data from the Human Genome Project allowed the investigators to more quickly recognize individual variations in genes, called polymorphis...Cyclosporine inhibits hepatitis C virus in vitro
...ts transplanted for HCV infection and may offer an advantage to Tacrolimus in those patients undergoing IFN-based therapy," the authors report. In addition, they confirm antiviral activity by the drug in cell cultures, having found that, "combination of Cyclosporine and interferon achieve better antiviral effe...Study reveals classic symbiotic relationship between ants, bacteria
...d until now. What other organisms might be taking advantage of this type of association? What don't we know about other systems that are not as closely studied as these ants?" Currie's collaborators include Michael Poulsen and Jacobus Boomsma of the University of Copenhagen, John Mendenhall of the Universit...Jefferson researchers building a better rabies vaccine
...tant outer glycoprotein, that a vaccine that takes advantage of immune reactions to this protein can be effective. Dr. Dietzschold explains that the current wildlife rabies vaccine used in the United States is ineffective in a chief carrier: skunks. The vaccine developed by his team is much broader, showing e...BioMed Central launches Biology Direct
...hip between authors and reviewers, will be a major advantage for everyone involved - authors, readers, and revi...tself, thus ensuring a high standard of review. An advantage of selecting one's own reviewers is the ability to choose people who will at least understand the ar...Groovy protein essential for promoting cancer development
... successful structural analysis. His strategy took advantage of the fact that when multiple copies of the fluorescent protein clump together, the fluorescence is quenched, or extinguished. So Jacobs engineered bacteria to produce fragments of the telomerase enzyme fused to the fluorescent protein. Since telome...Report lists top 20 most-vulnerable African carnivores
... successful structural analysis. His strategy took advantage of the fact that when multiple copies of the fluorescent protein clump together, the fluorescence is quenched, or extinguished. So Jacobs engineered bacteria to produce fragments of the telomerase enzyme fused to the fluorescent protein. Since telome...Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
...l cell or virus. Discher and his colleagues take advantage of the polymersome properties to ferry their drug combination to the tumor. The large polymers making up the shell allow paclitaxel, which is water-insoluble, to embed within the shell. Doxorubicin, which is water-soluble, stays within the interior...Stem cell transplants improve recovery in animal models for stroke, cerebral palsy
...splant, according to company executives. Another advantage is that use of immunosuppressive drugs does not appear to be required, in contrast to other types of stem cell treatment. Animals that received MultiStem TM without immunosuppression of any kind did just as well as animals that received MultiStem T...Biofuels can replace about 30 percent of fuel needs with significant research and policy effort
... integrated biorefinery, which is designed to take advantage of advances in plant science and innovative biomass conversion processes and equipment to produce fuels, power and chemicals from biomass. The biorefinery would work much like a petroleum refinery, which produces multiple fuels and products from pet...New method enables gene disruption in destructive fungal pathogen
...on in most filamentous fungi. The new method takes advantage of a novel linear DNA construct that greatly improves the efficiency of targeted gene disruption. The DNA construct includes an antibiotic-resistance marker gene, which allows for easy selection of the new mutants, as well as a short partial target g......th in containers. Moreover, this substrate has the advantage that it can be recycled and is more economic than ...e (Finland, Sweden, Norway, etc.). This is why the advantage of the product developed by the Public University of Navarre research team and the Aralur company is...VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum
...ounds. The enhanced uptake into cancer cells takes advantage of weak molecular interactions on the cells' surface. These results underscore the importance of the new compound's "non-covalent" interactions, prior to the attack on DNA. Non-covalent interactions minimize potential side reactions and produce chang...Nanopore method could revolutionize genome sequencing
...nto the signal being recorded. The new idea takes advantage of the electric field that drives the current perpendicular to the DNA strand to reduce the structural fluctuations of DNA while it moves through the pore, thus minimizing the noise. "If nature was very unkind, then the DNA would always fluctuate so...'Prosthetic' retinal cells let blind mice see light
...replace the photoreceptor function. "An important advantage of the strategy sought in this study is that it does not involve the introduction of tissues or devices into the retina and, therefore, may largely avoid the complications of immune reactions and biocompability," wrote the researchers. "In addition, ...Inflammation and drugs to control this activity studied in a variety of tumors sites
... also produced by precancerous tissues. They took advantage of a tissue bank from the Mayo Clinic Benign Breast Disease Cohort, which includes several thousand women who, between 1967 and 1991, had a benign breast biopsy. Of this group, 235 women had atypical hyperplasia and tissue available for the study. Ca...APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal
...accination," von Andrian said. Many pathogens take advantage of the lymph system to gain access to the body, he noted, including pathogens used in biological warfare, such as anthrax, or yersinia pestis, the agent that causes the plague. Bubonic plague, for instance, starts with a flea that deposits a few bac...With cochlear implants, earlier use leads to better speech
...s, but cochlear implants give a tremendous hearing advantage over hearing aids -- the implants provide more sound information," Nicholas says. "For example, high-frequency sounds are magnified more with cochlear implants, so kids can hear 's' sounds and 'ed' endings better. So they tend to catch on to plurals ...Malignant melanoma cells secrete protein required for embryo formation
... or cancer spread. The Northwestern study takes advantage of these similarities by using the developing zebr...ic nature of malignant melanoma cells serves as an advantage by enhancing the cells' ability to migrate, invade and metastasize virtually undetected by the immun...