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Tag: "advanced" at biology news

Novel method reveals how menthol discovery could point towards new or improved pain therapies

...vate or block them." The study was released in an advanced online version by the journal Nature Neuroscience. It will be published in the journal's April edition (Vol. 9, No. 4). Utilizing a novel mutagenesis and high-throughput screening approach, the study assayed 14,000 TRPM8 mutants to find mutants tha...

Therapeutic prospects beyond Vioxx

...hat bypass this issue, as reported in the April 13 advanced online edition and May print issue of The Journal of Clinical Investigation. "Although these results are in mice, not people, they raise an exciting possibility which can be tested in humans," says senior author Garret FitzGerald, MD, Director of Pe...

New test to detect rare proteins in blood

...cian in Greene's lab, report their findings in the advanced online publication of Nature Medicine. "The curr...arly treatment is far more effective than treating advanced tumors with the same antibodies. Recent clinical trials support the notion that early treatment prev...

The giant protein titin helps build muscles

... clues to sarcomere assembly. The Gautel lab used advanced microscope techniques to watch the molecules link to each other in live cells. "We knew that telethonin acted as a sort of 'cap' or 'bolt' at the end of the titin molecule," Gautel says. "What we couldn't see is how it connected two separate copies o...

Two NIH initiatives launch intensive efforts to find roots of common diseases

... this initiative, NIH will develop technologically advanced measures of dietary intake, precise personalized measures of physical activity, and biological measures that identify prior exposures to potential toxins such as metals and solvents. NIH also will assess disease indicators like inflammation and oxida...

Georgia Tech accelerates drug discovery with new IBM supercomputing cluster

...ology with the computing power they require to for advanced scientific research." Also included with the solution is IBM Rear Door Heat eXchanger (code named "Cool Blue,") a technology component that can use the existing chilled water supply for air conditioning systems already located in the majority of cus...

UCLA scientists uncover mechanism of response to targeted therapy

...A in a Phase I study on patients with a variety of advanced cancers. Researchers noted that patients with kidney cancer seemed to respond better to the drug than patients with other cancer types. That led to a Phase II study solely in kidney cancer patients. That study showed that a subset of patients had a c...

Scientists develop a way to make the deadliest toxin known even more toxic

...for the activation. The study was released in an advanced online version by the Journal of the American Chemical Society. Kim Janda, currently the Ely R. Callaway Jr. professor of chemistry, director of the Worm Institute for Research and Medicine (WIRM), and head of the laboratory that conducted the stud...

Basic research leads to a novel cancer therapy

...tolerate Imatinib at all. Still other patients had advanced renal cell carcinoma with failed available treatme...inib, compared to the placebo group. Patients with advanced renal cell carcinoma saw a shrinking of the tumour; in 26 to 37 percent of them, the tumour shrunk t...

Protein 'nanosprings' most resilient found in nature

...hines. The team's findings were published in an advanced online publication of Nature on Jan. 15, 2006. The finding that the protein components, called "ankyrin repeats," exhibit such unprecedented elastic properties could lead to a new understanding of how organisms, including humans, sense and respond t...

Curry and cauliflower could halt prostate cancer

...nd resources devoted to treatment. This is because advanced prostate cancer cells are barely responsive even to high concentrations of chemotherapeutic agents or radiotherapy. The authors noted that in contrast to the high incidence of prostate cancer in the United States, the incidence of this disease is ve...

Earth Rx: A microbial biotechnology prescription for global environmental health

...d on their ribosomal RNA. These technologies have advanced into high-throughput genomic and proteomic protocols that can detect specific genes and their metabolic functions with great precision and detail. Other methods can now reconstruct entire genomes of what were once "unculturable" microbes. Rittmann...

Botox could help target resistant tumors for treatment

...ients. "Tumor vasculature is targeted by several advanced anti-cancer approaches that may appear contradictory," said Gallez. "Anti-angiogenesis and anti-vascular targeting are methods aimed at destroying the vessels that feed tumors, thereby depriving them of oxygen and nutrients. "In contrast, pro-vascu...

Researchers solve mystery of how nuclear pores duplicate before cell division

...lear pore complex into the nuclear membrane. Using advanced real-time imaging tools the scientists watched as a nuclear membrane ?pores and all ?formed within an hour. "We were able to visualize single nuclear pore complexes," says graduate student and co-first author Daniel Anderson. "This allowed us not o...

Scientists one step closer to cancer vaccine

...ds new possible ways of developing a treatment for advanced tumour diseases." The newly published study is a continuation of an original discovery that first identified the TEIPP-T cell and that was presented in Ms Wolpert's doctoral thesis at Karolinska Institutet in 1998. The spread of tumours, or metasta...

Anthrax inhibitor counteracts toxin, may lead to new therapeutics

... by targeting the bacteria, but do not counter the advanced destructive effects of anthrax toxin in the body. Anthrax toxin is a polyvalent protein complex in that it displays multiple copies of identical binding surfaces on the same structure. The inhibitor designed by the Rensselaer-Toronto team is also po...

A surprising pair of proteins help make healthy eggs

...ure developing eggs. The finding, published in an advanced online edition of the Proceedings of the National Academy of Sciences, provides an important piece of the reproduction puzzle, and it points to possible drug targets for treating infertility and ovarian cancer. "Thousands of women in this country un...

Environmental metagenomics diagnosing extreme environments, tapping opportunities for clean energy

...ue, St. Louis, MO. The session will also highlight advanced sensing technologies, biosphere monitoring platforms, and ecosystem forecast models for predicting the impacts of climate change. For a full session description, see: http://php.aaas.org/meetings/MPE_01.php?detail=974 "Environmental systems are ex...

Researchers get neurons and silicon talking

...h nearer term the new technology could enable very advanced and sophisticated drug screening systems for the pharmaceutical industry. "Pharmaceutical companies could use the chip to test the effect of drugs on neurons, to quickly discover promising avenues of research," says Professor Stefano Vassanelli, a m...

Gene needed for butterfly transformation also key for insects like grasshoppers

...is equivalent to the pupal, or chrysalis, stage of advanced insects such as butterflies. Metamorphosis evolved in insects about 300 million years ago from ancestors of direct-developing insects such as grasshoppers. Biologists know the broad gene regulates metamorphosis in flies and moths and is found only a...

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