Stanford/Packard scientist's data-mining technique strikes genetic gold
... Jan. 6 online issue of Nature Biotechnology. The advance comes with a caveat, however: clinically useful nuggets will be buried under the avalanche of data inundating international repositories each year unless scientists come up with a way to better classify their experiments and results. "Libraries figu...NHGRI announces new sequencing targets
...oposal for a set of genomes to sequence that would advance knowledge in one of three important scientific areas: to identify areas in genetic research where the application of high-throughput sequencing resources would rapidly lead to significant medical advances; understanding of the human genome; and under...... D. Anderson Cancer Center. The study, issued in advance of the Feb. 21 edition of the Proceedings of the National Academy of Sciences, demonstrates for the first time that the oddly shaped DNA can cause DNA breaks in mammalian cells. Interestingly, these sequences prone to forming Z-DNA are often found ...Cracking the genetic code for control of gene expression
...Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled. The results of this work are published in Cell, in January 2006. A genome milestone was reached in 2001 when sequencing of the human genome was completed. This has been followed by com...Research details how a virus hijacks cell signals to cause infection
...t viruses can co-opt kinase signaling processes to advance an infection." In describing how the coxsackievirus takes advantage of signaling pathways, added Dr. Bergelson, his investigations revealed steps in a virus's life cycle that were previously unknown. "Eventually this understanding may yield clinical...UCLA scientists uncover mechanism of response to targeted therapy
...ew cancer therapy start work in cell lines andthen advance to laboratory animals to test their theories. Working backward from responsesin clinical trials is unusual, Thomas said. Responses observed in clinical studies led researchers back to the laboratory. Their laboratory findings will be tested in furthe...Georgia Tech accelerates drug discovery with new IBM supercomputing cluster
The Center will use IBM technologies to advance research into new drugs for the treatment of some ...'s brightest students to join our research team to advance medicines that will improve the well-being of people everywhere." BellSouth worked closely with G...A new way of looking at molecular motors
...ceedings of the National Academy of Sciences, with advance online publication February 6, 2006. Bernardo Foth, a postdoctoral fellow in Soldati's laboratory, is the first author. Soldati and Foth became interested in myosins after they discovered that the molecular motors enabled toxoplasmosis and malaria ...Scientists develop malaria forecasting tool to predict disease risk
... predict epidemics of malaria up to five months in advance has been developed by a scientist at the Universit... level of risk of an epidemic up to five months in advance of the peak malaria season ?the earliest point at which predictions have ever been made. The model ...Study: Paramedics save more lives when they don't follow the rules
... of Medicine chose to publish the report online in advance of the journal's April print issue. "Cardiocerebral Resuscitation eliminates certain previously recommended procedures and reprioritizes the order of actions the emergency medical services deliver," said Michael J. Kellum, MD, leading author of the...Groovy protein essential for promoting cancer development
...he researchers, who published their findings in an advance online publication in Nature Structural & Molecular Biology on February 5, 2006. Howard Hughes Medical Institute President Thomas R. Cech, whose laboratory is at the University of Colorado at Boulder, led the study, conducted with colleagues St...Report lists top 20 most-vulnerable African carnivores
...he researchers, who published their findings in an advance online publication in Nature Structural & Molecular Biology on February 5, 2006. Howard Hughes Medical Institute President Thomas R. Cech, whose laboratory is at the University of Colorado at Boulder, led the study, conducted with colleagues St...Enzyme crystal structure reveals 'unexpected' genome repair functions
The study is being published in an advance online version of the journal Molecular Cell. The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action tha...Unraveling the viral mechanism
...nd, some day, interrupt that disease process. The advance occurred because of innovations in computational method development in addition to the powerful cryoelectron microscopes operated at very low specimen temperature and very high energy that Chiu and others use in their work that looks at different bio...Nanopore method could revolutionize genome sequencing
...sequence DNA as it passes through tiny pores. The advance brings personalized, genome-based medicine closer to reality. The paper, published in the April issue of the journal Nano Letters, describes a method to sequence a human genome in a matter of hours at a potentially low cost, by measuring the electri...Wisconsin scientists grow two new stem cell lines in animal cell-free culture
...ile the new Wisconsin work represents an important advance for stem cell technology, the ability to now grow embryonic stem cells in cultures free of animal products could accentuate the debate over federal funding for research on additional stem cell lines. The Senate is expected to take up the issue early ...Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic
...n the U.S.," added Longini. The results show that advance preparation of a modestly effective vaccine in large quantities appears to be preferable to waiting for the development of a well-matched vaccine that may not become available until a pandemic has already reached the United States. "Because it is cu...APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal
...g, he said. Others have also worked to develop and advance the technology, von Andrian said. His lab's distinction was in adapting the technology for use in lymphoid organs in live animals. ...Discovery may speed forest biotechnology
... Science. They represent a significant fundamental advance in explaining the annual growth cycles and reproduction of trees. By knowing the genes that control these processes, it should be possible to genetically engineer trees that flower and reproduce more quickly. The long, slow growth of trees before th......a cell begins the process of self-destruction - an advance they say may help in the design of more targeted cancer therapies. In the June 30 issue of the journal Cell, the research team found that a natural "brake" exists in a cell to prevent it from undergoing apoptosis, or programmed cell death, and t...