'Bad' enzymes may wear white hats after stroke
... of Nature Medicine, and were made available in an advance online publication on March 26, 2006. Matrix metalloproteinases are a large group of enzymes that help break down the extracellular matrix, a complex structure that surrounds and supports cells. Newer research is showing that MMPs may also contribu...Chemical warfare agent detection technology used to treat lung disease
...l Mobility Spectrometer (DMS) and is a significant advance over the current Ion Mobility Spectrometer (IMS) systems which are currently deployed in airports to detect minute traces of explosives or drugs. The microDMx sensor is able to identify molecules that may be the cause of lung diseases such as cancer,...For one Stanford doctor, the beat goes on during open-heart surgery
...conventional bypass. "Beating-heart surgery is an advance in cardiac surgery because it provides a better result for patients," said John Puskas, chief of cardiothoracic surgery at Emory Crawford Long Hospital, Atlanta, and one of the 12 authors of the paper. Still, scientific evidence does not yet conclus...Junk DNA may not be so junky after all
... in zebrafish embryos. The system is a significant advance over current methods in this model species, allowing researchers to study more sequences in a shorter period of time. Using this, they identified several human enhancers able to control expression consistent with the zebrafish ret gene. Zebrafish ha...Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice
... in zebrafish embryos. The system is a significant advance over current methods in this model species, allowing researchers to study more sequences in a shorter period of time. Using this, they identified several human enhancers able to control expression consistent with the zebrafish ret gene. Zebrafish ha...Cell barrier shows why bird flu not so easily spread among humans
...flu can thus be monitored in a way to provide more advance warning of a potential pandemic. "Identification of H5N1 viruses with the ability to recognize human receptors would bring us one step closer to a pandemic strain," says Kawaoka. "Recognition of human receptors can serve as molecular markers for the...Sweet 'water taste' paradoxically predicts sweet taste inhibitors
... how humans detect sweet taste. Reporting in an advance online publication in Nature, scientists from the Monell Chemical Senses Center describe how certain artificial sweeteners, including sodium saccharin and acesulfame-K, paradoxically inhibit sweet taste at high concentrations. The researchers further...Ancient DNA provides clues to the evolution of social behavior
...l 20 edition of the journal PLoS Genetics. ''This advance in the analysis is fundamentally different from anything anyone has done with ancient DNA,'' says Hadly, an associate professor of biological sciences and co-author of the study. ''What we're trying to do is basically make a moving picture of their h...NJIT engineer poised to take stem cell research a step forward
...tients' knees during surgery. Arinzeh's drive to advance the science of stem cell research has gained her national recognition. Two years ago, she earned the highest honor given to a young researcher by President Bush: The Presidential Early Career Award for Scientists and Engineers. Her research has als...Treating populations infected with HIV and latent TB could speed the emergence of drug-resistant TB
...t strategy has flaws. Their findings appear in the advance online edition of the May 2, 2006 issue of Proceedings of the National Academy of Sciences. The researchers, led by Ted Cohen, doctoral student at HSPH, and senior author Megan Murray, Assistant Professor of Epidemiology, developed a mathematical mo...UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
...ouse all metagenomic data that will facilitate and advance knowledge of marine microbial ecology, other natur...enhance our health science researchers' ability to advance the development of new drugs and therapies from the ocean's resources to combat cancer and neurodege...Front-line immune cells mature in four stages, study shows
...ave eluded investigators until now. The findings advance the understanding of NK cells, which play a key role in triggering broader immune responses such as the body's permanent protection following vaccination. Understanding the secrets of NK cell development in humans could lead to new therapies for canc...Sea coral's trick helps scientists tag proteins
...l 2006 issue of Nature Biotechnology, published in advance online on March 19, 2006. Importantly, Dendra is small enough to highlight proteins without interfering with their folding or function. And the researchers have demonstrated that it can switch shades at the body temperature of birds and mammals, whi...A new focus for the mechanism of nerve growth
...th cones use the information they gather to direct advance of the nerve cells and it has long been known that such advance depends on the coordinated assembly of actin filament networks. This study implicates the molecula...Oh, rats! Designer animals reveal possible heart disease genes
... In a four-year study published in the January 15 advance online publication of Nature Genetics , researchers at The Institute for Genomic Research (TIGR) and the Medical College of Wisconsin (MCW) systematically bred and studied 43 designer rats with and without high blood pressure, in order to pinpoint c...Minor mutations in avian flu virus increase chances of human infection
... published on March 16, 2006 by ScienceXpress, the advance online version of the journal Science. Receptor specificity for the influenza virus is controlled by the glycoprotein hemagglutinin (HA) on the virus surface. These viral HAs bind to host cell receptors containing complex glycans-carbohydrates-that ...Scientists seek to unwrap the sweet mystery of the sugar coat on bacteria
...duate student Ken Hsu report their findings in the advance on-line edition and March issue of Nature Chemical Biology. The scientists studied the sugar coats of four strains of bacteria: two lab strains of E. coli, one pathogenic strain of E. coli that causes neonatal meningitis, and Salmonella typhimurium,...Hantavirus found in African wood mouse
...covery of an African hantavirus will significantly advance the understanding of hantavirus evolution and of rodent evolution." The researchers originally collected hundreds of African rodents during a study of the variability of Lassa virus--another rodent-borne virus--in its hosts and in humans. They start...Tool developed to silence genes in specific tissues using RNAi
...cific tissue or cell type represents a significant advance in the field," says the study's lead investigator, Miles Wilkinson, Ph.D., a professor in the Department of Immunology. For example, this method could potentially be used in humans "to knockdown the expression of mutant or overexpressed genes that c...Findings advance use of adult stem cells for replacement bone
In a significant advance for regenerative medicine, researchers at Rice University have discovered a new way to culture adult stem cells from bone marrow such that the cells themselves produce a growth matrix that is rich in important biochemical growth factors. The researc...