Learning how SARS spikes its quarry
...sses about infectivity, so that we can better give advance warning." He also noted that laboratory studies indicate that the fragment of the spike protein they used could provide the basis of a vaccine against SARS, since it appears to be recognized by the immune system of the host. In future studies, Ha...Vaccine targets tumors where they live
...ed B7.1. In a study appearing online on June 2 in advance of the print publication of the July 1 print issue of the Journal of Clinical Investigation, Howard Kaufman and colleagues from Columbia University manipulate the local tumor environment as a method for improving systemic anti-tumor immunity. This co...Protease inhibitors reach beyond HIV
...in vivo. In a study appearing online on June 2 in advance of the print publication of the July 1 print issue of the Journal of Clinical Investigation, Andrew Badley and colleagues from Mayo Clinic examine whether PIs can inhibit programmed cell death in vivo and the mechanisms involved. The authors show tha...MSKCC researchers uncover structure of key protein complex in cells
...ation, but how they do so remains unclear. A major advance in this study was the development of quantitative assays that allowed us to develop a more sophisticated model for E3 activity," Dr. Lima said. "This model has broad implications for the function of E3s in all ubiquitin and ubiquitin-like conjugation...NASA satellite data provides rapid analysis of Amazon deforestation
... above - satellites. This technology continues to advance and a new study shows that NASA satellite images can allow scientists to more quickly and accurately assess deforestation in the Amazon. Researchers from the University of Maryland-College Park, Brazil's National Institute for Space Research (INPE) ...Scientists discover genetic pathway responsible for breast cancer cell growth
...he MUHC have made an important discovery that will advance our understanding of how the female hormone estrogen causes growth of breast cancer cells. The research, in collaboration with scientists at the Institut de Recherches Cliniques de Montreal (IRCM) identifies 153 genes that respond to estrogen and one...Neurotransmitters signal aggressive cancer, offer potential for early diagnosis
...ases. The resulting information will significantly advance diagnosis and treatment options. "We used a way to cross from basic sequence information in genomes to information about the substances likely to arise in tumors" says Ippolito. The research team first analyzed the activity of genes in the mouse tu...North & South American researchers find architectural abnormalities in T. cruzi ribosome
...tiate protein translation." The findings may also advance studies of parasitic relatives Trypanosoma brucei, which causes sleeping sickness in Africa, and Leishmania, a parasite spread by sand flies. Higher resolution models of the ribosome structure will be needed to design targeted drugs, Frank said. ...NHGRI expands effort to revolutionize sequencing technologies
...s awarded grants totaling more than $32 million to advance the development of innovative sequencing technologies intended to reduce the cost of DNA sequencing and expand the use of genomics in biomedical research and health care. "The efforts are aimed at speeding the rate at which the next generation of se...Grand Challenges in Global Health initiative funds Yale project
...es in basic science and clinical research. It will advance research on diseases that have an effect on communities worldwide." The goal of this award is to provide to the research community a suitable model system to test live attenuated vaccines for use in the developing world. Flavell said the mice genera...What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brain's Internal Clock
... understanding timing and time perception, to help advance this exciting field." ...'License to kill' enables powerful immune attack cells in mice
... rest of their lives. "This could be an important advance both conceptually and in terms of clinical practice," Yokoyama says. "It could also help us match bone marrow transplants in a way that increases the immune system's ability to fight off a relapse of the leukemia." ...Complex gene interactions account for autism risk
...o the neurological underpinnings of autism, we may advance toward new therapies." Collaborators on the study include D.Q. Ma, P.L. Whithead, M.M. Menold, E.R. Martin, A.E. Ashley-Koch, G.R. DeLong and J.R. Gilbert, all of Duke; H. Mei of North Carolina State University; M.D. Ritchie of Vanderbilt University...Method slashes quantum dot costs by 80 percent
...lvents with cheap processing fluidsIn an important advance toward the large-scale manufacture of fluorescent quantum dots, scientists at Rice University have developed a new method of replacing the pricey solvents used in quantum dot synthesis with cheaper oils that are commonplace at industrial chemical pla...The right drug at the right time
...lvents with cheap processing fluidsIn an important advance toward the large-scale manufacture of fluorescent quantum dots, scientists at Rice University have developed a new method of replacing the pricey solvents used in quantum dot synthesis with cheaper oils that are commonplace at industrial chemical pla...Study hints at role of stem cell genes in testicular, breast cancers
...ll genes, scientists have reasoned, could cause or advance cancer. Substantial evidence already suggests, in fact, that genes in adult stem cells ?which reside in many tissues of the body ?cause some leukemias, and that they may cause gliomas, the most common form of brain tumor (UCSF - Nature, Feb. 19, 200...Scientists develop nanotech-laser treatment that kills cancer cells without harming healthy tissue
...y--using the unique properties of nanomaterials to advance biology and medicine." Dai's graduate student, Nadine Wong Shi Kam, is lead author of the PNAS study. Other co-authors are Michael O'Connell, a former postdoctoral fellow in the Department of Chemistry, and graduate student Jeffrey A. Wisdom in the ...Solexa and collaborating scientists illuminate the small RNA component of the transcriptome
...g genes expressed at low levels, without requiring advance knowledge of the genes or sequences of interest. Solexa performed this research in its Genomic Services business unit. The Company also intends to develop this small RNA assay for use with its next-generation sequencing platform, which is scheduled t...Sudden change in social status triggers genetic response in male fish, study finds
..., the subordinate male perceives an opportunity to advance in social status and responds both behaviorally and by turning on genes that ultimately make him capable of reproducing," notes Fernald, the Benjamin Scott Crocker Professor of Human Biology at Stanford. This finding offers the first direct evidence...