Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
...Disease Control and Prevention, such a dose for an adult is as little as approximately 500 micrograms of ricin, an amount that would fit on the head of a pin. The results from the UT Southwestern trial justify further development of the vaccine, Dr. Vitetta said. "We have shown that this vaccine is safe...UCSD study finds anthrax toxins also harmful to fruit flies
.... Learning how these toxins attack developing and adult tissues is important because it can help scientist... and can cause severe malformation in the wings of adult fruit flies--an effect that can also be understood as an interruption of another unrelated signaling...Infant transplant patients resist infections that kill adult AIDS patients
...ients resisted the same infections that often kill adult AIDS patients. The transplant patients maintained ...it perhaps could be therapeutically manipulated in adult patients to arrive at new and better treatments for various diseases involving immune system deficie...Stem cells from muscles can repair cartilage
...e for performing MDSC implantation in cartilage of adult humans, since 12-week-old rats are considered to b...ermine the chondroprogenitor potential of MDSCs in adult humans and their capacity to form cartilage in vivo." ...Parents need to be educated about HPV vaccinations for daughters
...en are most susceptible in their teenage and young adult years. "The origins of cervical cancer lie in HPV infection of the cervix, a sexually transmitted infection most frequently acquired by women shortly after they start sexual activity. In a minority of women, the HPV infection persists and may resul...Diabetes researchers pioneer islet cell xenotransplantation in primate studies
...chers; those researchers used islets isolated from adult pig pancreases. Neonatal islets were produced in ...post-transplant, considered a major advantage over adult pig islets. The diabetic animals were treated with a CD28/CD154 co-stimulation blockade-based immun...Ancient DNA helps UF researchers unearth potential hemophilia therapy
...tempted such an approach on an animal so young. In adult mice, the immune system normally views clotting pr... the immune attack when performing gene therapy on adult animals. "I don't think the research is done," Mah said. "But this is definitely a step forward for...Duke to test bird flu vaccine dosing
...uminum hydroxide is commonly used in pediatric and adult vaccines, including those for whooping cough, hepatitis A and hepatitis B. As with current flu vaccines given yearly in the U.S., the H5N1 vaccine causes the body's immune system to make antibodies to fight infection. In previous studies with this v...H5N1 avian flu virus vaccine induces immune responses in healthy adults
...dy, eventually enrolling an additional 333 healthy adult volunteers into the trial according to the same protocol design as in stage one. The NEJM article describes an analysis of data on the safety and immune responses to the vaccine. In general, the higher the dosage of vaccine, the greater the antibo...Liver cancer linked to cellular repair pathway
...t, Hedgehog tells cells where and when to grow. In adult tissue, it signals the body to grow new tissue. "If the liver is injured badly, it uses some of the same mechanisms to repair itself as a fetus uses in growing a liver," Diehl said. The Hedgehog pathway is also linked to certain brain, skin and musc...Neurons find their place in the developing nervous system with the help of a sticky molecule
...birthplace to the position they will occupy in the adult brain. Researchers at the Salk Institute for Biological Studies have identified a molecule expressed on the surface of certain migrating neurons that helps them find their correct position along on the way. Decreasing levels of that protein, an adh...Rice bioengineers pioneer techniques for knee repair
...colonies of donor cells. Donor cells can be either adult stem cells or other immature cells. Athanasiou's latest work was done using chondrocytes, or cartilage cells. Athanasiou, a former president of the international Biomedical Engineering Society, helped pioneer the development of coin-sized scaffolds ...Gene needed for butterfly transformation also key for insects like grasshoppers
...gely the same from the time it hatches through its adult stage. New University of Washington research sho...aid. The organism eventually becomes an adult, but adult structures such as the wings are severely undersized. "Broad is not required to transform into the ...'Uniquely human' component of language found in gregarious birds
...ch as rattle-Rattle-Warble-warble (aABb). Eleven adult birds were given lessons on distinguishing between these two sets of songs using classic reinforcement techniques. The birds were rewarded with food when they heard a song from the context-free set and for refraining when they heard one from the fini...Fruit fly's beating heart helps identify human heart disease genes
...ity to accurately image heart function of a living adult fly. Past investigators have measured the size of ...in dilated cardiomyopathy in humans, we imaged the adult fly with this novel system and what we saw looked exactly like the same condition in humans," Wolf s...Boosting newborns' immune responses
...t mimic viral antigens, the cells produced normal, adult levels of two key cytokines ?TNF-alpha and IL-12 ?...covering other differences between the newborn and adult immune systems that could lead to additional targets for drugs or vaccines. A related paper, to be p...Infections could contribute to adult brain tumours
...uld play a key role in triggering certain types of adult brain cancer, according to results from a new stat...The British and Dutch team* analysed a database of adult brain tumours diagnosed in patients from the North Brabant province of the Netherlands between 1983 ...New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
...if the use of embryonic stem cells and circulating adult stem cells will achieve the same function. "This new evidence offers hope that this is a treatment strategy that can be explored for other diseases that result from extracellular matrix defects," he notes. Study coauthors include BIDMC researcher...Powerful technique for multiplying adult stem cells may aid therapies
...es. Chief among these is the doggedness with which adult stem cells differentiate into mature tissue the mo...rs to multiply them in the laboratory. And because adult stem cells are so rare, that makes it difficult to use them for treating disease. Now, researchers...Pittsburgh researchers discover that certain chemicals in the blood may indicate brain injury
...is so important for physicians to realize that the adult who brings a child to the Emergency Department may have no idea that the child is being abused by another family member, babysitter, family friend or nanny." ...