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Tag: "administered" at biology news

A gene's first 'kiss' sets off that affair known as puberty

...hibernation. Within 30 minutes of kisspeptin being administered to male monkeys, LH, one of the hormones stimulated by GnRH secretion, was no longer dormant, with levels 25-times higher than its baseline of zero. In addition to Dr. Plant, other authors of the PNAS paper are Muhammad Shahab, Ph.D., formerly a fel...

Controversial drug shown to act on brain protein to cut alcohol use

...ipitously when theyreceived Ibogaine. The drug was administered either by injection ordirectly into the same brain...ing when whenalcohol is again available. When they administered Ibogaine, they foundthat the heightened craving and consumption was significantly reduced."The disco...

Novel antiviral technology inhibits RSV infection in mice

...NA interference targeting avirus's NS1 gene can be administered in the form of a nasal drop orspray. The treatment keeps the host's natural antiviral shield intactand attenuates virus reproduction, providing substantial protectionfrom severe infections over days to weeks."Dr. Mohapatra and his team developed nose...

Poplar trees redirect resources in response to simulated attack

...ves of poplar trees in a closed chamber. They then administered carbon dioxide gas "labeled" with radioactive carbon-11 to individual leaves, where it is quickly converted to sugar, and traced the movement of this radiolabeled sugar through the plants using autoradiography and other techniques. Autoradiography al...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

...ents will be randomly assigned to receive the gene administered through a cardiac catheter threaded into the heart from a leg artery or a placebo delivered using the same method. As required by the U.S. Food and Drug Administration, the study is "double blinded," which means that neither the doctor nor the patien...

Bone Density Recovers After Teens Stop Injected Contraceptive

...y, that the loss is greater the longer the drug is administered and that bone density loss may not be completely reversible after discontinuation of the drug. The FDA warning states: “Depo-Provera Contraceptive Injection should be used as a long-term birth control method (e.g. longer than 2 years) only if other ...

Effective Cancer Treatments Follow The Clock

...ed high sensitivity to the drug at any time it was administered ?as if the drug were administered early in the morning or late at night. In contrast, the Cryptochrome knockout mice showed more resis...

Chemists identify immune system mechanism for methamphetamine binges

... antibodies to the drug could be mass produced and administered at therapeutic levels that are high enough to clear the drug from the body, he says. "Methamphetamine has become the ‘crack' of the 21st century," Janda says. "We're just starting to unravel its mechanism of addiction." Further studies of the drug a...

Alzheimer's cognitive decline slowed

...on (MMSE), which evaluates cognitive function, was administered at screening, the time of treatment and at several intervals after treatment. Over an average post-treatment follow-up period of 22 months, the rate of decline on the MMSE among NGF-treated patients was reduced by as much as 51 percent. An additional...

Nanoparticles offer new hope for detection and treatment

... be ten to a thousand times higher than if you had administered the drug systemically," Lanza says. The nanoparticles also may permit more effective follow up, because a doctor could use them to discern whether a tumor was still growing after radiation or chemotherapy treatments. Although this study focused on ...

Canada approves marijuana-based pain spray

...t shown to have therapeutic properties. Sativex is administered via a spray into the mouth. Health Canada has app...S Society of Canada. How Sativex works Sativex is administered through a spray pump under the tongue or on the inside of the cheek, providing reliable, self-admini...

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

...e researchers have also found that Enigmols can be administered orally and appear in often-difficult-to reach organs such as the prostate. "This is what suggested to us that Enigmols should be tested against other cancer types," Merrill explained. Subsequently, the researchers found that Enigmols suppress the gr...

NIAID begins clinical trial of West Nile virus vaccine

...DNA plasmid into muscle cells, the vaccine will be administered by a needle-free injector rather than a conventional needle syringe. Volunteers will be monitored for possible symptoms or side effects as well as the body's ability to generate WNV-specific antibodies and T cells. The vaccine cannot cause West Nile ...

MUHC researchers make cancer target breakthrough

...ticularly effective in reducing cancer tumors when administered in low doses and in combination with established cancer drugs. "All drugs and antisense have some level of toxicity," says Dr. Rozen. "An antisense that works in harmony with other drugs, and in such low doses, is a significant breakthrough in cancer...

Thai spice helps cut blood sugar swings

..., reducing insulin output In the study, rats were administered HCA prior to "mimicking a meal by infusing sugar into the stomach," explained lead author Wielinga. "Compared with controls, which had no HCA, the test rats' rise in blood sugar was much slower, but over 2 ½ hours all the sugar was absorbed." In add...

UCLA cancer researchers shake loose hidden biomarker

...y-based immunotherapies as well, and they could be administered in the blood," he said. Rajasekaran said PSMA is an important biomarker for prostate cancer and its expression in the cell is proportional to the severity of the cancer ?the more advanced the disease, the more PSMA is expressed. Rajasekaran and his...

Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs

... combination. "Our recombinant fusion protein was administered orally, and when tested in mice, increased the white blood cell count for three days, whereas the injectable agents only maintain effectiveness for one day," Shen says. "We have finally produced an orally-administered protein with a desirable therape...

Newly discovered genetic disease sheds light on body's water balance

...tric endocrinology fellow Eric Huang, MD, Gitelman administered urea, a natural nitrogen compound that encourages urination by acting as an osmotic agent. As water flowed out of their bodies and sodium concentrations returned to normal, both babies recovered. They continue to be followed by the UCSF team. Next G...

Redesigned protein accelerates blood clotting

...ent consists of genetically engineered factor VIII administered by injection, but one quarter of those born with no factor VIII suffer severe immune reactions that render the treatment inactive. In addition, current treatment costs as much as $200,000 per patient per year. Researchers at the University of Rochest...

Nicotine triggers the same brain reward circuitry as opiates

...he June 16, 2005, issue of Neuron, the researchers administered nicotine to mice and analyzed the levels of a protein called CREB--known to control genes involved in the reward pathway of opiates and other abused drugs. They found that not only was CREB activated in the reward regions of the nicotine-treated anim...

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