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Tag: "adjuvant" at biology news

Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer

... breast cancer treated with radical mastectomy and adjuvant chemotherapy, the addition of radiation therapy le...that in situations where residual disease remains, adjuvant chemotherapy alone in high-risk breast cancer patients is suboptimal and that the addition of locore...

Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down

... breast cancer treated with radical mastectomy and adjuvant chemotherapy, the addition of radiation therapy le...that in situations where residual disease remains, adjuvant chemotherapy alone in high-risk breast cancer patients is suboptimal and that the addition of locore...

Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy

...ancer cells." The vaccine, combining the CpG 7909 adjuvant and Incomplete Freund's Adjuvant (IFA) with a synthetic peptide (protein fragment) from a melanoma antigen known as Melan-A/MART-1, induced CD8+ T cells that specifically recognized cells displaying Melan-A/MART-1 on their surface. This T cell respon...

Wake Forest scientists find new combination vaccine effective against plague

...ve also established that flagellin is an effective adjuvant in monkeys immunized with flagellin and a Yersina ...g foundation for the future use of flagellin as an adjuvant in humans," Mizel said. He said the research shows that the mice were protected for at least three ...

Microarray technology for tailoring breast cancer therapy

...edict a patient's response in the five years after adjuvant therapy for breast cancer. Identifying patients wh...d to predict which patients would not benefit from adjuvant therapy, and avoid patients being given therapies with the potential of causing more harm than good....

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

...uch as tetanus, are typically administered with an adjuvant and can confer immunity for years. Dr. Smallshaw is currently determining whether the vaccine protects against aerosol and oral administrations in mice. "In a recent series of experiments, we have shown that the vaccine protects mice against lethal...

DNA gene vaccine protects against harmful protein of Alzheimer's disease

...ity of causing brain inflammation. Furthermore, no adjuvant was needed for antibody production. The gene immunization is now undergoing further animal studies, with the ultimate goal being a clinical trial in humans. The researchers also plan to see if it can reverse the size of established plaques in the br...

Duke to test bird flu vaccine dosing

...ine. "We hope that by adding a compound called an adjuvant to the vaccine, we can create a stronger immune re...with or without an aluminum hydroxide adjuvant. An adjuvant works by increasing the body's immune response to a vaccine, Walter said. Aluminum hydroxide is comm...

'Bad' enzymes may wear white hats after stroke

...agic effect of tPA and might someday be used as an adjuvant therapy with tPA," she said. "I also did some work with beta amyloid, the protein implicated in Alzheimer's disease. It seems that beta amyloid might increase levels of MMP-9 where MMPs would harm rather than help, and statins might help counteract t...

Potential vaccine developed for deadly leishmaniasis disease

...e delivery vehicle, immune-stimulating antigen and adjuvant into one package. The delivery vehicle is an influenza virosome ?the empty envelope of the influenza virus. These flu virus shells contain none of the infectious genetic material in full-fledges flu viruses. The virosome also acts as an "adjuvant," ...

Botox could help target resistant tumors for treatment

... cosmetic treatment Botox may have a new use as an adjuvant to cancer therapy, providing an open door for chemotherapy and radiation treatments, according to a study published in the Feb. 15 issue of Clinical Cancer Research. The study in mice, led by Bernard Gallez, Ph.D., professor of pharmacy at the Univ...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...ients who, independent of stage, should be offered adjuvant chemotherapy, and groups of patients who should not be offered chemotherapy," Nielsen said. "Such possible patient differentiation should, of course, be confirmed in prospective studies." Such a study is currently underway in Denmark and other Scand...

AIDS-related cognitive impairment exists in two separate forms

...ients who, independent of stage, should be offered adjuvant chemotherapy, and groups of patients who should not be offered chemotherapy," Nielsen said. "Such possible patient differentiation should, of course, be confirmed in prospective studies." Such a study is currently underway in Denmark and other Scand...

Vaccine shown effective against chancroid

...moglobin receptor substance and testing it with an adjuvant approved for human use. ...

St. Jude test of bird flu vaccine proves successful

...ated with the company's Vaxfectin TM adjuvant. An adjuvant is an additive administered with a vaccine that has little effect by itself, but improves the response of the immune system to the vaccine. ...

H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses

...es," says NIAID Director Anthony S. Fauci, M.D. An adjuvant is a substance that is added to a vaccine to boost... Currently, MF59 is licensed for use as a vaccine adjuvant in Europe but not in the United States. The results of this trial, says Dr. Atmar, suggest that MF59...

Bird flu vaccine additive may stretch supply

...nfected at all. "What we found was that when the adjuvant material was included in the vaccine--at all dosag...ever, mild pain or swelling was more common in the adjuvant group....

Other patients bear the real cost of Herceptin

... with Herceptin, but at four times the cost of the adjuvant treatments, they say. These treatments have been p...eptin if they did not treat 355 patients receiving adjuvant treatment (16 of whom would be cured) or 208 patients receiving palliative chemotherapy, and if they...

Chemotherapy temporarily affects the structures of the human brain

...e study reveals that within 12 months of receiving adjuvant chemotherapy, significant regions of the brain ass...conclude that "these results lead to the idea that adjuvant chemotherapy could have a temporary effect on brain structure."...

Gene signature assesses breast cancer outcomes

...ature can better identify who can safely be spared adjuvant chemotherapy in 6000 women with node-negative earl...tool could safely spare 1 in 6 women the burden of adjuvant chemotherapy. ...

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