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Tag: "adipose" at biology news

New player in commitment to life as a fat cell

...tion since it is both necessary and sufficient for adipose differentiation both in vitro and in vivo, the res... exhibited increased XOR activity and urate in the adipose tissue. Urate is a salt derived from uric acid. "Our results identify XOR as a potential therapeu...

Liposuctioned fat stem cells to repair bodies

...d methods work is not surprising, perhaps, because adipose tissue is closely related to bone, cartilage, muscle and other connective tissue. But some say it is impossible to re-programme adult cells to become nerve or liver cells, for example, without using embryos. Adult stem cells, such as those from fat, ...

Magic Beans -- Anti-obesity soya could help prevent diabetes

...aving an effect on fat metabolism in the liver and adipose tissue, reducing synthesis of new fatty acids and ...lin action, mainly as a result of excess abdominal adipose tissue - so loss of weight often improves glycaemic control,?says Dr Bender. Lynne Garton, a regi...

Major link in brain-obesity puzzle found

... tissues of the body, including fat cells known as adipose tissue, as well as the liver, heart, pancreas and muscle. Rui and his team also explored the role of SH2B1 in fat cells, finding that the knockout mice that lacked the SH2B1 gene stored away much more fat than normal mice, and had much larger fat...

'Exercise pill' switches on gene that tells cells to burn fat

... had in being able to turn on the PPAR-d switch in adipose or fat cells, activating local metabolism and increasing the amount of calories burned. As a Howard Hughes Medical Investigator at The Salk Institute’s Gene Expression Laboratory, Dr. Evans discovered the role of the gene for PPAR-d, the master regul...

Tuberculosis: The bacillus takes refuge in adipose cells

... for tuberculosis can hide, in a dormant state, in adipose cells throughout the body. The bacterium is protec...st demonstrated, in cell and tissue cultures, that adipose cells served as a reservoir for Mycobacterium tuberculosis, and that this protected the bacillus aga...

Fat stem cells being studied as option for breast reconstruction

...orted that adult stem cells could be isolated from adipose tissue, more commonly known as fat. Since then, laboratory studies have suggested adipose-derived stem cells have potential for treating heart attack, stroke or bone injury, although there have been no clinical trials in the U.S. to date. Experts est...

Expanding waistlines triggered by your genes

...r and expand girth. Excess fat is stored in white adipose tissue, the primary energy depot in the body, prim...round their bellies were very small, but the brown adipose tissue, a specialized fat depot to regulate body energy consumption, was unaffected. Importantly, t...

Gene linked to rare disease activates fat breakdown

...ports that CGI-58 boosts the activity of so-called adipose triglyceride lipase (ATGL) up to 20-fold. "We kne... a new picture of how stored fat is broken down in adipose and other tissues." The finding solves a puzzle first raised in 2001 with the discovery that CGI-58...

Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet

...aduate student in Montminy's lab. TRB3 levels in adipose tissue usually rise only during fasting, when ACC should be turned off. Heredia and co-first author Ling Qi, Ph.D., reasoned that keeping the TRB3 pathway artificially "on" during both fasting and feeding might melt away fat depots. And that's exact...

Potential heart benefit found in stem cells

... from the animals' subcutaneous fat tissues (ADSC, adipose derived stem cells). After repairing the hearts, ...of the study. "We believe that stem cells from the adipose tissues may be a valuable novel alternative source for helping support cardiac regeneration after a ...

UCSD study clarifies insulin's role in blocking release of energy in patients with type II diabetes

...ores energy primarily as triglycerides, or fat, in adipose tissue to be used later. When energy is needed, catecholamine triggers activation of PKA, and energy is released. But in people with Type II diabetes, the hormonal balance has been thrown off, because the body continues to produce and store more trig...

Lack of enzyme turns fat cells into fat burners

...etyl CoA carboxylase 2or ACC2, appears to turn the adipose or fat cells of mice into fatburners, explaining i...chemistry and molecularbiology. "We found that the adipose in the mutant mice are nowoxidizing fat, hydrolyzing (breaking down using water) fat, and passingit ...

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(Date:4/16/2014)... NJ (April 16, 2014): Celldex Therapeutics, Inc. (NASDAQ: ... 1 study of CDX-1401 in solid tumors, including long-term ... Medicine (Vol 6 Issue 232). The data demonstrate ... clinical benefit in patients with very advanced cancers and ...
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