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Tag: "adhesion" at biology news

Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants

...rcysteine-rich adhesin (SCA) - a plant pollen tube adhesion protein.This labeled the protein molecules with fluorescent tags.Quantum dots are much more resistant to photobleaching thanconventional fluorescent markers and their small size make them idealfor biological imaging. The researchers then added the mo...

Needling Chromosomes Reveals Cell Division Secret

...ofchromosomes in each cell manage to balance their adhesion to oneanother and their release during cell divisi...ess of cell division. The exquisite management of adhesion properties between newly divided chromosomes, called chromatids, is crucial if the cells are to divi...

Vital step in cellular migration described by UCSD medical researchers

...describes how a the interaction of alpha4 integrin adhesion receptor with a protein called paxillin creates directional movement of a cell by inhibiting a protein called Rac. "Understanding how this protein contributes to directional movement of a cell provides a new insight into cell migration and ultimatel...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...geted cells translate signals into changes in cell adhesion and remodeling, proliferation, and differentiation—the agents of most types of organogenesis. Since Snail, a protein that impedes the transcription of a subset of genes, functions in many developmental processes requiring epithelial remodeling, the ...

Anti cancer virotherapy well tolerated in first human administration, research finds

...s by attaching to the cells' ICAM-1 (intercellular adhesion molecule-1) and DAF (decay accelerating factor). This CVA21 technology which has been identified by Professor Shafren and his team to be effective in killing cancer cells, is on-licensed to Psiron, as has Echovirus Type 1 (EV1), which has shown prom...

Enzyme's newly discovered role may make it target for arthritis treatment

... rearrangement of integrins, an important group of adhesion compounds on the surface of neutrophils. "The way these integrins rearrange and cluster on the cell surface can send a signal back into the cell that modifies the cell's behavior, allowing it to do things like secrete inflammatory factors," Pham exp...

Study finds adult stem cells can replicate

... rearrangement of integrins, an important group of adhesion compounds on the surface of neutrophils. "The way these integrins rearrange and cluster on the cell surface can send a signal back into the cell that modifies the cell's behavior, allowing it to do things like secrete inflammatory factors," Pham exp...

Simple sea sponge helps scientists understand tissue rejection

... for laboratory research, since its cells and cell adhesion molecules can be isolated with simple, fast, and non-disruptive methods and studied, and because its fingerlike structures make grafting experiments relatively straightforward. In experiments carried out on these sponges this summer, Dr. Fernndez-Bu...

Researcher uncovers details of how cancer spreads

...und that v-Src attaches to an enzyme, called focal adhesion kinase, inside the cell. This association jump-starts a series of cascading interactions between proteins in the cell that ultimately block some cell-surface proteins from entering through the cell's membrane. One of the proteins not allowed entry i...

Researchers learn how blood vessel cells cope with their pressure-packed job

...alignment of stress fibers as well as alignment of adhesion sites where those stress fibers would attach to the cell membrane."These new results clearly show that Rho and physical stresses cooperate to produce healthy alignments of stress fibers," said Chien. "We need to understand how cells can sense the mec...

Give thanks for the cranberry, say dental researchers

... the same is true in the mouth, where bacteria use adhesion molecules to hold onto teeth," Koo said. Koo's team also found evidence that cranberry juice disrupts the formation of the building block of plaque, known as a glucan. Like a mason using cement to build a wall brick by brick, bacteria use enzymes kn...

Scientists observe how a close bond activates the immune system

...ynthetic dendritic cell using purified antigen and adhesion molecules (molecules that the cell can grip) in a thin fluid coating on a glass surface. In prior studies the antigen was free to move over the entire glass surface, but in this study they set up miniscule chrome barriers, allowing them to modify th...

Neurons find their place in the developing nervous system with the help of a sticky molecule

...n the way. Decreasing levels of that protein, an adhesion molecule called MDGA1, prevents neurons that norma...s Gesemann, Ph.D. They showed that MDGA1 is a cell adhesion molecule ?a protein enabling cells to attach to other surfaces, something that they must do either t...

Biologists visualize protein interaction that may initiate viral infection

...abbing non-integrin. ICAM stands for intercellular adhesion molecule, a family of cell proteins that viruses bind to, and the number 3 defines a specific protein. "The binding occurs on dendritic cells, which are usually one of the first lines of defense in the immune system," Kuhn said. "The first step in a...

Berkeley researchers lay groundwork for cell version of DNA chip

...n a thumbnail-sized chip) using our DNA-based cell adhesion strategy," said Ravi Chandra, a researcher affilia...tical to an organism's health and well-being. Cell adhesion is now being used to incorporate biological cells into simple devices, but is expected to be importa...

Molecular force field helps cancer cells defend against attack

...ncer Research. "We have found a gene called focal adhesion kinase which is produced at very high levels in hu...ately associated with tumor cell survival." Focal adhesion kinase, or FAK, is commanding increasing attention and has spawned a flurry of research designed to ...

Scientists stop autoimmune disease without shutting off immune system

... of cell-signaling events that lead to the loss of adhesion or "stickiness" between skin cells. Thus, it stops the disease without affecting the immune system. "There are a number of companies developing inhibitors of the p38 enzyme for treating rheumatoid arthritis and psoriasis," Rubenstein said. "Our stu...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

...nt, Sood said, because the targeted protein, focal adhesion kinase (FAK), is inside the cell, rather than on the cell surface where most proteins targeted by cancer drugs are found. "Targets like FAK, which are difficult to target with a drug, can be attacked with this liposomal siRNA approach, which penetra...

New light microscope sharpens scientists' focus

...lular structures, including actin filaments, focal adhesion proteins, mitochondria, and the Golgi apparatus. "Performance-wise, it's just astounding. And simplicity-wise it's astounding," Betzig said. "It knocks the socks off of standard fluorescence microscopy from a resolution perspective." Hess added, "...

MRSA vaccine shows promise in mouse study

... and SdrE, are thought to be involved in bacterial adhesion to host tissues. When tested alone as a vaccine, each of the four proteins provided only partial or no protection. Fifty to 70 percent of mice vaccinated with one of these proteins and injected with a dose of a laboratory strain of the bacteria ca...

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